ENSG00000162585

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378546 ENSG00000162585 HEK293_OSMI2_6hA HEK293_TMG_6hB FAAP20 protein_coding protein_coding 99.28221 158.8823 30.63649 40.81868 1.690194 -2.374255 71.883238 120.545605 17.289362 34.1541708 1.0090976 -2.800908 0.6643167 0.74316667 0.56413333 -0.17903333 0.01578055 0.004866669 FALSE TRUE
ENST00000400919 ENSG00000162585 HEK293_OSMI2_6hA HEK293_TMG_6hB FAAP20 protein_coding protein_coding 99.28221 158.8823 30.63649 40.81868 1.690194 -2.374255 5.352337 7.127131 2.026605 0.7058309 0.2510010 -1.809178 0.0668625 0.05013333 0.06563333 0.01550000 0.72989006 0.004866669 FALSE TRUE
ENST00000476803 ENSG00000162585 HEK293_OSMI2_6hA HEK293_TMG_6hB FAAP20 protein_coding processed_transcript 99.28221 158.8823 30.63649 40.81868 1.690194 -2.374255 9.374367 11.934785 5.645144 1.3149641 0.6725079 -1.078745 0.1279792 0.08370000 0.18303333 0.09933333 0.04859575 0.004866669 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162585 E001 0.6368449 0.019177066 6.085970e-01   1 2184461 2184463 3 - 0.000 0.187 11.473
ENSG00000162585 E002 1.5176405 0.012487067 2.573836e-01 4.961256e-01 1 2184464 2184477 14 - 0.521 0.288 -1.301
ENSG00000162585 E003 114.9451546 0.221252182 6.323994e-01 7.918974e-01 1 2184478 2185174 697 - 1.941 1.910 -0.105
ENSG00000162585 E004 39.7008202 0.341840606 6.970790e-01 8.336676e-01 1 2185175 2185223 49 - 1.515 1.453 -0.211
ENSG00000162585 E005 55.4039185 0.469290407 6.818225e-01 8.238347e-01 1 2185224 2185364 141 - 1.663 1.592 -0.241
ENSG00000162585 E006 30.1637915 0.378912813 9.019829e-01 9.528983e-01 1 2185365 2185397 33 - 1.537 1.306 -0.796
ENSG00000162585 E007 42.5731480 0.247691327 8.314475e-01 9.146606e-01 1 2185398 2185513 116 - 1.566 1.479 -0.300
ENSG00000162585 E008 11.7777862 0.208517205 7.064220e-01 8.395973e-01 1 2186004 2186249 246 - 1.115 0.943 -0.630
ENSG00000162585 E009 23.3841173 0.329668029 8.220524e-01 9.091346e-01 1 2186838 2187206 369 - 1.432 1.202 -0.804
ENSG00000162585 E010 4.5872003 0.114506025 5.632922e-01 7.455960e-01 1 2189544 2189546 3 - 0.752 0.600 -0.641
ENSG00000162585 E011 4.5989668 0.126002840 3.721436e-01 6.056981e-01 1 2189547 2189547 1 - 0.806 0.586 -0.918
ENSG00000162585 E012 25.6721698 0.001341284 3.857158e-02 1.510457e-01 1 2189548 2189568 21 - 1.126 1.314 0.665
ENSG00000162585 E013 44.4069048 0.001981920 9.801177e-03 5.726700e-02 1 2189569 2189579 11 - 1.355 1.544 0.651
ENSG00000162585 E014 305.7837846 0.001121344 2.012649e-04 2.689174e-03 1 2189580 2189712 133 - 2.260 2.356 0.320
ENSG00000162585 E015 431.3191067 0.001535365 5.471361e-04 6.103678e-03 1 2189713 2189781 69 - 2.426 2.499 0.244
ENSG00000162585 E016 156.6156902 0.059563874 6.188113e-04 6.742817e-03 1 2189782 2191900 2119 - 2.396 1.945 -1.507
ENSG00000162585 E017 104.8562931 0.042638096 2.253848e-04 2.951536e-03 1 2191901 2192646 746 - 2.213 1.777 -1.463
ENSG00000162585 E018 37.3996789 0.012207629 9.721952e-07 2.772479e-05 1 2192647 2192844 198 - 1.776 1.340 -1.493
ENSG00000162585 E019 75.5925757 0.003163337 2.868481e-06 7.150067e-05 1 2192845 2192975 131 - 1.968 1.683 -0.963
ENSG00000162585 E020 41.6205658 0.151347128 1.382332e-02 7.363145e-02 1 2192976 2193638 663 - 1.872 1.358 -1.753
ENSG00000162585 E021 1082.8270013 0.007828828 7.382329e-02 2.324140e-01 1 2193639 2193910 272 - 2.852 2.889 0.124
ENSG00000162585 E022 635.9325744 0.008546688 3.980740e-01 6.267942e-01 1 2193998 2194133 136 - 2.638 2.656 0.058
ENSG00000162585 E023 35.1077841 0.008123749 2.233607e-01 4.573841e-01 1 2194134 2194213 80 - 1.525 1.387 -0.473
ENSG00000162585 E024 333.2124427 0.016281735 1.036614e-03 1.018638e-02 1 2194688 2194793 106 - 2.188 2.398 0.704
ENSG00000162585 E025 1.4865455 0.141949363 2.489428e-01 4.866983e-01 1 2198007 2198062 56 - 0.523 0.281 -1.358
ENSG00000162585 E026 0.7429626 0.020850704 7.765744e-01   1 2198063 2198142 80 - 0.249 0.187 -0.528
ENSG00000162585 E027 0.6064850 0.037557823 6.086829e-01   1 2198143 2198753 611 - 0.000 0.187 13.247
ENSG00000162585 E028 2.4625974 0.059050005 1.379640e-01 3.443987e-01 1 2198754 2201049 2296 - 0.687 0.371 -1.517
ENSG00000162585 E029 0.1779838 0.038378068 7.287330e-02   1 2201050 2201225 176 - 0.249 0.000 -14.960
ENSG00000162585 E030 0.2027342 0.040484236 1.000000e+00   1 2203436 2203563 128 - 0.000 0.055 11.244
ENSG00000162585 E031 0.2027342 0.040484236 1.000000e+00   1 2203564 2203630 67 - 0.000 0.055 11.244
ENSG00000162585 E032 0.0000000       1 2203631 2203882 252 -      
ENSG00000162585 E033 0.3559677 0.538579350 4.605528e-02   1 2206305 2206424 120 - 0.414 0.000 -14.660
ENSG00000162585 E034 0.5339515 0.918925516 7.408966e-02   1 2206515 2206667 153 - 0.538 0.000 -15.134
ENSG00000162585 E035 0.0000000       1 2207556 2207733 178 -      
ENSG00000162585 E036 1.8452557 0.323913167 8.315051e-01 9.146937e-01 1 2212171 2212371 201 - 0.411 0.332 -0.458
ENSG00000162585 E037 0.0000000       1 2212372 2212458 87 -      
ENSG00000162585 E038 0.0000000       1 2212549 2212720 172 -