ENSG00000162441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377213 ENSG00000162441 HEK293_OSMI2_6hA HEK293_TMG_6hB LZIC protein_coding protein_coding 22.85009 9.79608 30.66678 1.767832 1.649963 1.645399 11.887709 5.018053 15.278125 0.5234047 1.4810258 1.6043398 0.51965833 0.5311 0.4959667 -0.03513333 9.250996e-01 8.062948e-13 FALSE TRUE
ENST00000377223 ENSG00000162441 HEK293_OSMI2_6hA HEK293_TMG_6hB LZIC protein_coding protein_coding 22.85009 9.79608 30.66678 1.767832 1.649963 1.645399 7.641956 3.410046 9.875167 0.7073270 0.3507235 1.5312499 0.34097917 0.3437 0.3226333 -0.02106667 8.949907e-01 8.062948e-13 FALSE TRUE
ENST00000400903 ENSG00000162441 HEK293_OSMI2_6hA HEK293_TMG_6hB LZIC protein_coding protein_coding 22.85009 9.79608 30.66678 1.767832 1.649963 1.645399 1.582654 0.000000 3.960295 0.0000000 0.6244112 8.6331024 0.04805417 0.0000 0.1282333 0.12823333 8.062948e-13 8.062948e-13 FALSE TRUE
MSTRG.268.1 ENSG00000162441 HEK293_OSMI2_6hA HEK293_TMG_6hB LZIC protein_coding   22.85009 9.79608 30.66678 1.767832 1.649963 1.645399 1.616457 1.312557 1.449183 0.5699197 0.8178199 0.1418315 0.08225000 0.1203 0.0496000 -0.07070000 5.164041e-01 8.062948e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162441 E001 8.3214107 0.1496551502 8.557288e-02 0.2556468129 1 9922113 9922358 246 - 0.781 1.174 1.466
ENSG00000162441 E002 530.2961312 0.0001593531 1.487320e-01 0.3604640972 1 9926293 9929719 3427 - 2.678 2.700 0.074
ENSG00000162441 E003 144.3783426 0.0003000198 2.759373e-05 0.0005015036 1 9929720 9930252 533 - 2.157 2.020 -0.459
ENSG00000162441 E004 36.2883295 0.0013408124 1.337652e-02 0.0719449221 1 9930253 9930260 8 - 1.571 1.405 -0.570
ENSG00000162441 E005 116.2527866 0.0010027623 2.312441e-02 0.1063493428 1 9930261 9930457 197 - 2.052 1.966 -0.288
ENSG00000162441 E006 107.0263212 0.0005835444 7.391036e-01 0.8598427518 1 9931891 9931972 82 - 1.992 2.007 0.048
ENSG00000162441 E007 0.7013366 0.0384487382 9.015277e-01   1 9931973 9932180 208 - 0.208 0.179 -0.271
ENSG00000162441 E008 122.6565952 0.0003390030 4.547062e-01 0.6692863178 1 9932803 9932898 96 - 2.044 2.071 0.091
ENSG00000162441 E009 137.0802935 0.0004750154 3.017288e-01 0.5422733316 1 9934762 9934860 99 - 2.087 2.121 0.116
ENSG00000162441 E010 159.7740868 0.0002844264 2.655972e-01 0.5049880396 1 9935492 9935627 136 - 2.156 2.190 0.115
ENSG00000162441 E011 150.4846495 0.0004976407 7.048169e-01 0.8386026183 1 9936519 9936627 109 - 2.145 2.135 -0.033
ENSG00000162441 E012 148.3548440 0.0004863791 9.964842e-01 0.9999455856 1 9942624 9942782 159 - 2.135 2.137 0.005
ENSG00000162441 E013 32.8631387 0.0013060877 2.878163e-02 0.1237225469 1 9943249 9943348 100 - 1.451 1.592 0.484
ENSG00000162441 E014 16.1049770 0.0048134394 6.895934e-01 0.8287721411 1 9943349 9943407 59 - 1.174 1.212 0.132