ENSG00000162437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294428 ENSG00000162437 HEK293_OSMI2_6hA HEK293_TMG_6hB RAVER2 protein_coding protein_coding 14.31072 7.564299 21.95592 1.286874 0.4244138 1.536082 1.3676002 0.7527087 1.30912446 0.27931989 0.18395952 0.7903766 0.09949583 0.09540000 0.05953333 -0.03586667 0.716037475 0.008161842 FALSE TRUE
ENST00000371072 ENSG00000162437 HEK293_OSMI2_6hA HEK293_TMG_6hB RAVER2 protein_coding protein_coding 14.31072 7.564299 21.95592 1.286874 0.4244138 1.536082 10.6421314 5.6852210 17.71405216 1.08454430 0.50810558 1.6378847 0.70212083 0.74520000 0.80656667 0.06136667 0.495980486 0.008161842 FALSE TRUE
MSTRG.1353.5 ENSG00000162437 HEK293_OSMI2_6hA HEK293_TMG_6hB RAVER2 protein_coding   14.31072 7.564299 21.95592 1.286874 0.4244138 1.536082 0.9312905 0.2773269 2.08479213 0.11232981 0.05353530 2.8660421 0.05548333 0.03883333 0.09510000 0.05626667 0.312439836 0.008161842 TRUE TRUE
MSTRG.1353.7 ENSG00000162437 HEK293_OSMI2_6hA HEK293_TMG_6hB RAVER2 protein_coding   14.31072 7.564299 21.95592 1.286874 0.4244138 1.536082 0.9409661 0.6695432 0.07741993 0.04513488 0.07741993 -2.9585313 0.11492917 0.09506667 0.00350000 -0.09156667 0.008161842 0.008161842 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162437 E001 7.3213980 0.0043614912 6.897478e-02 2.227198e-01 1 64745075 64745084 10 + 0.807 1.035 0.861
ENSG00000162437 E002 9.2920706 0.0036936487 7.456053e-02 2.339179e-01 1 64745085 64745094 10 + 0.905 1.111 0.762
ENSG00000162437 E003 10.4353402 0.0035553467 5.304895e-02 1.868647e-01 1 64745095 64745134 40 + 0.946 1.160 0.782
ENSG00000162437 E004 8.8571522 0.0038117813 7.325151e-02 2.313261e-01 1 64745135 64745185 51 + 0.882 1.093 0.783
ENSG00000162437 E005 35.9647447 0.0105190890 9.699710e-01 9.868343e-01 1 64745186 64745421 236 + 1.516 1.523 0.023
ENSG00000162437 E006 46.7605450 0.0015866650 2.817420e-01 5.220826e-01 1 64768656 64768722 67 + 1.646 1.590 -0.191
ENSG00000162437 E007 220.3678847 0.0002649479 5.727925e-05 9.367458e-04 1 64777623 64778065 443 + 2.327 2.229 -0.327
ENSG00000162437 E008 55.4822129 0.0006697734 5.013943e-01 7.017998e-01 1 64778066 64778092 27 + 1.696 1.739 0.148
ENSG00000162437 E009 0.9662812 0.0941512874 1.149688e-01   1 64780709 64780755 47 + 0.344 0.001 -9.873
ENSG00000162437 E010 127.7090580 0.0004936939 7.852238e-02 2.418329e-01 1 64781380 64781571 192 + 2.080 2.028 -0.176
ENSG00000162437 E011 92.0579235 0.0004832755 8.143350e-04 8.398179e-03 1 64789388 64789514 127 + 1.960 1.828 -0.444
ENSG00000162437 E012 73.7130366 0.0005785904 2.073399e-02 9.844575e-02 1 64802976 64803061 86 + 1.858 1.759 -0.332
ENSG00000162437 E013 1.2729203 0.0134214728 2.880704e-01   1 64804734 64804772 39 + 0.381 0.181 -1.442
ENSG00000162437 E014 72.6756568 0.0006033062 3.849255e-01 6.164709e-01 1 64804773 64804838 66 + 1.832 1.801 -0.105
ENSG00000162437 E015 86.9190940 0.0005895676 1.023477e-01 2.859797e-01 1 64804991 64805049 59 + 1.915 1.854 -0.206
ENSG00000162437 E016 87.1965750 0.0025565099 1.198631e-01 3.156432e-01 1 64805050 64805105 56 + 1.920 1.851 -0.231
ENSG00000162437 E017 16.0102318 0.0272888063 1.707196e-02 8.572525e-02 1 64805106 64805146 41 + 1.255 0.943 -1.130
ENSG00000162437 E018 166.6973585 0.0003580500 8.483338e-02 2.543189e-01 1 64807206 64807474 269 + 2.191 2.147 -0.146
ENSG00000162437 E019 84.6235005 0.0004721641 9.346591e-01 9.695651e-01 1 64812738 64812849 112 + 1.887 1.893 0.020
ENSG00000162437 E020 105.4951792 0.0004142621 5.741444e-01 7.531277e-01 1 64814704 64814840 137 + 1.988 1.977 -0.040
ENSG00000162437 E021 11.8556844 0.0387544570 2.158186e-01 4.484341e-01 1 64814841 64816509 1669 + 1.013 1.176 0.589
ENSG00000162437 E022 7.8427563 0.0041918978 3.590704e-01 5.951087e-01 1 64825254 64825408 155 + 0.936 0.826 -0.422
ENSG00000162437 E023 899.8235429 0.0004788587 2.519739e-11 2.024170e-09 1 64830839 64833232 2394 + 2.886 2.971 0.284