ENSG00000162384

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294360 ENSG00000162384 HEK293_OSMI2_6hA HEK293_TMG_6hB CZIB protein_coding protein_coding 54.96287 42.51832 47.41887 2.700893 2.670704 0.1573415 33.892701 25.436930 29.099243 3.1964369 2.74850340 0.1939857 0.61028333 0.59386667 0.61086667 0.01700000 0.972137862 0.004061139 FALSE  
ENST00000474227 ENSG00000162384 HEK293_OSMI2_6hA HEK293_TMG_6hB CZIB protein_coding retained_intron 54.96287 42.51832 47.41887 2.700893 2.670704 0.1573415 4.018104 3.145559 4.336957 0.2470853 0.12409880 0.4621100 0.07590417 0.07526667 0.09183333 0.01656667 0.762797858 0.004061139    
ENST00000489755 ENSG00000162384 HEK293_OSMI2_6hA HEK293_TMG_6hB CZIB protein_coding retained_intron 54.96287 42.51832 47.41887 2.700893 2.670704 0.1573415 3.365504 2.149120 4.334154 0.8165192 0.15766070 1.0086319 0.06460000 0.05360000 0.09236667 0.03876667 0.546794719 0.004061139    
MSTRG.1219.5 ENSG00000162384 HEK293_OSMI2_6hA HEK293_TMG_6hB CZIB protein_coding   54.96287 42.51832 47.41887 2.700893 2.670704 0.1573415 6.088049 6.077313 2.096294 1.4892338 0.03975606 -1.5310986 0.10633333 0.14050000 0.04440000 -0.09610000 0.004061139 0.004061139 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162384 E001 9.15087 0.1734386859 0.3766914126 0.609623727 1 53214099 53214136 38 - 0.940 1.064 0.459
ENSG00000162384 E002 124.74980 0.0162551994 0.3947283287 0.624089471 1 53214137 53214374 238 - 2.141 2.060 -0.272
ENSG00000162384 E003 137.61433 0.0070810141 0.1062337722 0.292744055 1 53214375 53214472 98 - 2.190 2.092 -0.326
ENSG00000162384 E004 78.80722 0.0026082947 0.2755431782 0.515614571 1 53214473 53214473 1 - 1.935 1.867 -0.227
ENSG00000162384 E005 83.96056 0.0040416165 0.3052853985 0.545905127 1 53214474 53214476 3 - 1.963 1.895 -0.227
ENSG00000162384 E006 368.36536 0.0014359359 0.6890708607 0.828485847 1 53214477 53214736 260 - 2.569 2.563 -0.020
ENSG00000162384 E007 215.93298 0.0017744593 0.0386347313 0.151206953 1 53215991 53216056 66 - 2.309 2.356 0.157
ENSG00000162384 E008 144.63602 0.0014498375 0.0860683125 0.256558232 1 53216782 53216785 4 - 2.140 2.181 0.140
ENSG00000162384 E009 246.17066 0.0029835637 0.1151109668 0.307632225 1 53216786 53216859 74 - 2.369 2.406 0.124
ENSG00000162384 E010 22.14163 0.1463739476 0.8016856350 0.897317890 1 53216860 53218171 1312 - 1.367 1.359 -0.030
ENSG00000162384 E011 175.52092 0.0025161534 0.1024339355 0.286131295 1 53218172 53218203 32 - 2.219 2.261 0.140
ENSG00000162384 E012 10.97405 0.0173989398 0.5834351283 0.759274019 1 53218204 53218360 157 - 1.107 1.030 -0.279
ENSG00000162384 E013 231.64074 0.0002514781 0.5692824090 0.749714983 1 53218414 53218495 82 - 2.365 2.361 -0.012
ENSG00000162384 E014 56.02510 0.0979319761 0.0660767113 0.216273400 1 53218496 53218866 371 - 1.872 1.620 -0.853
ENSG00000162384 E015 214.89012 0.0002252853 0.6212473125 0.784699643 1 53218867 53218923 57 - 2.346 2.318 -0.096
ENSG00000162384 E016 72.66560 0.0800802437 0.0865042130 0.257419306 1 53218924 53219534 611 - 1.971 1.751 -0.738
ENSG00000162384 E017 55.47153 0.0661909989 0.0259516244 0.115157240 1 53219535 53219969 435 - 1.878 1.599 -0.941
ENSG00000162384 E018 19.45252 0.0289062496 0.0005953404 0.006539618 1 53219970 53220086 117 - 1.477 1.078 -1.404
ENSG00000162384 E019 49.35855 0.0012696084 0.5149893501 0.711651896 1 53220087 53220260 174 - 1.692 1.709 0.058
ENSG00000162384 E020 237.91447 0.0002370042 0.0035596947 0.026706045 1 53220261 53220344 84 - 2.349 2.399 0.165
ENSG00000162384 E021 31.19667 0.0017640573 0.3373831448 0.575741088 1 53220345 53220476 132 - 1.544 1.466 -0.265
ENSG00000162384 E022 16.33048 0.0022465382 0.6566951950 0.807749597 1 53220477 53220569 93 - 1.229 1.251 0.077
ENSG00000162384 E023 129.00110 0.0044367220 0.0123601988 0.067873182 1 53220570 53220634 65 - 2.059 2.153 0.315