ENSG00000162062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361837 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding protein_coding 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 6.268196 14.244292 2.559205 2.5955259 1.2969467 -2.4720024 0.10215833 0.19536667 0.07906667 -0.11630000 7.188290e-01 3.204888e-08 FALSE  
ENST00000562253 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding retained_intron 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 2.858722 3.649650 3.315940 0.3086343 0.5714537 -0.1379436 0.06593750 0.05373333 0.10173333 0.04800000 3.252341e-01 3.204888e-08 FALSE  
ENST00000563531 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding protein_coding 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 2.937559 3.621355 4.420306 1.8109616 0.6125405 0.2868984 0.05857083 0.05936667 0.13676667 0.07740000 7.785526e-01 3.204888e-08 FALSE  
ENST00000566580 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding retained_intron 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 4.084617 4.062710 5.258654 1.5316200 0.2852867 0.3714455 0.09778333 0.06530000 0.16173333 0.09643333 2.723274e-01 3.204888e-08    
ENST00000567489 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding protein_coding 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 15.424773 23.600729 9.266638 4.4896121 0.5787813 -1.3477686 0.30504167 0.32313333 0.28496667 -0.03816667 8.083742e-01 3.204888e-08 FALSE  
ENST00000569496 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding protein_coding 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 4.232359 6.313191 0.000000 3.1442957 0.0000000 -9.3045089 0.08443750 0.07863333 0.00000000 -0.07863333 3.204888e-08 3.204888e-08 FALSE  
ENST00000569994 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding retained_intron 50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 4.930588 7.038150 2.372819 1.3883375 0.3570110 -1.5645754 0.09519167 0.09750000 0.07286667 -0.02463333 6.846099e-01 3.204888e-08 FALSE  
MSTRG.11864.2 ENSG00000162062 HEK293_OSMI2_6hA HEK293_TMG_6hB TEDC2 protein_coding   50.16519 72.23717 32.51776 11.36641 0.6064763 -1.15127 2.112896 0.000000 1.862266 0.0000000 1.3199696 7.5486414 0.05454583 0.00000000 0.05636667 0.05636667 2.226408e-01 3.204888e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162062 E001 0.9407076 0.0169669193 0.7094464144   16 2460086 2460093 8 + 0.201 0.274 0.579
ENSG00000162062 E002 1.8392888 0.0114458785 0.1863968533 0.412311184 16 2460094 2460101 8 + 0.201 0.468 1.715
ENSG00000162062 E003 3.0299662 0.0816811309 0.0655213565 0.215073178 16 2460102 2460108 7 + 0.201 0.630 2.473
ENSG00000162062 E004 9.3638265 0.0329239826 0.0724692176 0.229731384 16 2460109 2460117 9 + 0.709 1.003 1.138
ENSG00000162062 E005 32.7168532 0.0010542826 0.3057533809 0.546418416 16 2460118 2460133 16 + 1.517 1.444 -0.251
ENSG00000162062 E006 57.9522408 0.0008483798 0.9814679885 0.992519819 16 2460134 2460144 11 + 1.704 1.699 -0.018
ENSG00000162062 E007 70.8238485 0.0014861043 0.5819796281 0.758375103 16 2460145 2460156 12 + 1.770 1.793 0.080
ENSG00000162062 E008 84.4675866 0.0006534645 0.4212826588 0.644585200 16 2460157 2460170 14 + 1.838 1.871 0.113
ENSG00000162062 E009 27.3088120 0.0502927010 0.7317314535 0.855297747 16 2460171 2460282 112 + 1.355 1.385 0.105
ENSG00000162062 E010 130.0097583 0.0007117893 0.1636134351 0.382122279 16 2460283 2460381 99 + 2.011 2.061 0.169
ENSG00000162062 E011 49.6854024 0.0010375865 0.7597640901 0.872437624 16 2460382 2460475 94 + 1.656 1.635 -0.069
ENSG00000162062 E012 62.2740107 0.0007054683 0.2629912015 0.502192593 16 2460476 2460622 147 + 1.688 1.746 0.195
ENSG00000162062 E013 240.9891045 0.0007665223 0.5901330379 0.763823441 16 2460623 2460693 71 + 2.327 2.305 -0.073
ENSG00000162062 E014 19.7507670 0.0016867807 0.0015435729 0.013915181 16 2460694 2460815 122 + 1.440 1.179 -0.914
ENSG00000162062 E015 375.1999951 0.0003854036 0.1087166726 0.296954118 16 2460816 2460936 121 + 2.534 2.493 -0.136
ENSG00000162062 E016 551.8496632 0.0002159925 0.3079013322 0.548525355 16 2460937 2461224 288 + 2.688 2.666 -0.074
ENSG00000162062 E017 35.2780090 0.0449300332 0.0014049889 0.012937127 16 2461225 2461449 225 + 1.754 1.359 -1.351
ENSG00000162062 E018 39.1121921 0.1153139379 0.0083344056 0.050859671 16 2461547 2461746 200 + 1.828 1.379 -1.531
ENSG00000162062 E019 245.1326152 0.0022158772 0.1546824719 0.368972686 16 2461747 2461800 54 + 2.359 2.309 -0.167
ENSG00000162062 E020 336.1508100 0.0001786680 0.0722980428 0.229398369 16 2462149 2462239 91 + 2.491 2.448 -0.141
ENSG00000162062 E021 338.9159499 0.0001831114 0.4307540082 0.651705061 16 2462415 2462526 112 + 2.451 2.465 0.048
ENSG00000162062 E022 253.5781166 0.0003587804 0.0001728416 0.002366563 16 2462631 2462732 102 + 2.256 2.356 0.333
ENSG00000162062 E023 218.3116142 0.0035252345 0.0186311480 0.091165719 16 2464039 2464153 115 + 2.198 2.288 0.303
ENSG00000162062 E024 200.8579342 0.0048555303 0.0515118109 0.183317945 16 2464154 2464229 76 + 2.166 2.249 0.277
ENSG00000162062 E025 195.1100664 0.0054938200 0.5949000367 0.766976731 16 2464230 2464521 292 + 2.246 2.211 -0.116
ENSG00000162062 E026 444.6022265 0.0003825669 0.0963345302 0.275315858 16 2464522 2465320 799 + 2.555 2.584 0.097