ENSG00000161533

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293217 ENSG00000161533 HEK293_OSMI2_6hA HEK293_TMG_6hB ACOX1 protein_coding protein_coding 6.078759 3.163539 7.870587 0.7683389 0.07203634 1.312211 2.3334717 1.5066295 2.43473718 0.3227914 0.08483841 0.6888107 0.4182083 0.49543333 0.3092333 -0.18620000 0.159052086 0.006236273 FALSE TRUE
ENST00000301608 ENSG00000161533 HEK293_OSMI2_6hA HEK293_TMG_6hB ACOX1 protein_coding protein_coding 6.078759 3.163539 7.870587 0.7683389 0.07203634 1.312211 1.3330250 0.6959138 2.07010520 0.1952564 0.05491564 1.5590926 0.2049667 0.21633333 0.2631667 0.04683333 0.790778980 0.006236273 FALSE TRUE
ENST00000587927 ENSG00000161533 HEK293_OSMI2_6hA HEK293_TMG_6hB ACOX1 protein_coding protein_coding 6.078759 3.163539 7.870587 0.7683389 0.07203634 1.312211 0.5607221 0.5214264 0.05343804 0.1867590 0.05343804 -3.0664497 0.1183458 0.15450000 0.0069000 -0.14760000 0.006236273 0.006236273 FALSE TRUE
MSTRG.15105.3 ENSG00000161533 HEK293_OSMI2_6hA HEK293_TMG_6hB ACOX1 protein_coding   6.078759 3.163539 7.870587 0.7683389 0.07203634 1.312211 1.2272176 0.1834590 2.48029302 0.1586511 0.13042756 3.6862154 0.1598375 0.05406667 0.3149000 0.26083333 0.126710631 0.006236273 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000161533 E001 32.8121338 0.0014500959 1.655241e-04 2.284050e-03 17 75941507 75942136 630 - 1.418 1.657 0.820
ENSG00000161533 E002 9.8065483 0.0033178595 1.479928e-01 3.594573e-01 17 75942137 75942170 34 - 0.951 1.112 0.588
ENSG00000161533 E003 22.9903161 0.0021018636 5.643630e-03 3.795565e-02 17 75942171 75942595 425 - 1.277 1.488 0.733
ENSG00000161533 E004 27.8928902 0.0169054425 1.047850e-03 1.027597e-02 17 75942596 75942877 282 - 1.315 1.605 0.998
ENSG00000161533 E005 6.7051445 0.0056455666 4.070145e-03 2.956698e-02 17 75942878 75942878 1 - 0.706 1.063 1.372
ENSG00000161533 E006 10.4680580 0.0035483710 7.437749e-04 7.809936e-03 17 75942879 75942912 34 - 0.879 1.232 1.290
ENSG00000161533 E007 20.6902254 0.0017844838 2.999176e-07 9.849721e-06 17 75942913 75943100 188 - 1.144 1.537 1.372
ENSG00000161533 E008 15.3643656 0.0327245912 1.343161e-02 7.211725e-02 17 75943101 75943213 113 - 1.066 1.390 1.145
ENSG00000161533 E009 16.0197808 0.0186099983 3.953584e-02 1.535528e-01 17 75943214 75943410 197 - 1.129 1.355 0.795
ENSG00000161533 E010 88.5335705 0.0134522820 5.391976e-02 1.889133e-01 17 75943411 75945039 1629 - 1.887 2.007 0.405
ENSG00000161533 E011 127.0891550 0.0008956156 1.720398e-02 8.619652e-02 17 75945040 75946463 1424 - 2.106 2.033 -0.246
ENSG00000161533 E012 23.4108680 0.0044089443 9.604361e-01 9.820658e-01 17 75946464 75946529 66 - 1.358 1.362 0.014
ENSG00000161533 E013 21.2695565 0.0021085265 6.701667e-01 8.164079e-01 17 75946530 75946576 47 - 1.331 1.307 -0.085
ENSG00000161533 E014 38.6958488 0.0022390312 1.482167e-01 3.597557e-01 17 75946577 75946706 130 - 1.600 1.520 -0.274
ENSG00000161533 E015 42.1191221 0.0010241980 2.784355e-01 5.185471e-01 17 75946707 75946795 89 - 1.629 1.576 -0.179
ENSG00000161533 E016 63.8088462 0.0005848619 8.877376e-01 9.454541e-01 17 75948251 75948457 207 - 1.789 1.792 0.010
ENSG00000161533 E017 45.1746214 0.0008207808 6.382927e-01 7.959177e-01 17 75949217 75949360 144 - 1.628 1.662 0.116
ENSG00000161533 E018 31.7033172 0.0013293853 7.343000e-01 8.568456e-01 17 75949495 75949600 106 - 1.497 1.482 -0.048
ENSG00000161533 E019 47.8473163 0.0010621699 3.292476e-01 5.682587e-01 17 75949718 75949897 180 - 1.683 1.640 -0.145
ENSG00000161533 E020 51.6486728 0.0020253015 2.438729e-01 4.808904e-01 17 75950774 75950964 191 - 1.718 1.662 -0.190
ENSG00000161533 E021 43.4781382 0.0194161486 4.363251e-01 6.560086e-01 17 75951415 75951577 163 - 1.643 1.571 -0.247
ENSG00000161533 E022 0.1614157 0.0339842457 1.000000e+00   17 75953249 75953450 202 - 0.089 0.000 -9.439
ENSG00000161533 E023 41.3356138 0.0011455075 1.795114e-03 1.566716e-02 17 75953451 75953620 170 - 1.655 1.476 -0.614
ENSG00000161533 E024 38.1172493 0.0009985943 2.287264e-02 1.055387e-01 17 75955566 75955681 116 - 1.607 1.476 -0.449
ENSG00000161533 E025 27.0050133 0.0016657688 1.177869e-02 6.554899e-02 17 75955828 75955860 33 - 1.475 1.297 -0.616
ENSG00000161533 E026 32.6784502 0.0011623865 2.437433e-02 1.102408e-01 17 75955861 75955907 47 - 1.544 1.403 -0.485
ENSG00000161533 E027 27.7023228 0.0013174409 1.491540e-01 3.610184e-01 17 75955908 75955947 40 - 1.464 1.371 -0.322
ENSG00000161533 E028 0.1426347 0.0325040485 1.000000e+00   17 75957421 75957458 38 - 0.089 0.000 -9.443
ENSG00000161533 E029 28.7892038 0.0013757162 4.524749e-02 1.682335e-01 17 75957459 75957514 56 - 1.493 1.362 -0.453
ENSG00000161533 E030 27.1374868 0.0016680020 2.284003e-02 1.054441e-01 17 75957515 75957566 52 - 1.474 1.317 -0.545
ENSG00000161533 E031 24.3980697 0.0101358547 7.346507e-01 8.570840e-01 17 75960215 75960375 161 - 1.393 1.377 -0.057
ENSG00000161533 E032 0.0000000       17 75973309 75973624 316 -      
ENSG00000161533 E033 14.1598132 0.0031393093 6.626354e-01 8.115314e-01 17 75973625 75973785 161 - 1.144 1.195 0.181
ENSG00000161533 E034 1.6366223 0.0118276706 9.204813e-02 2.675182e-01 17 75978467 75978533 67 - 0.280 0.575 1.604
ENSG00000161533 E035 40.4623846 0.0083657449 4.762996e-01 6.844612e-01 17 75978534 75978693 160 - 1.611 1.577 -0.117
ENSG00000161533 E036 3.6373651 0.0068799153 9.111597e-01 9.577669e-01 17 75978791 75978964 174 - 0.644 0.669 0.109
ENSG00000161533 E037 30.6210226 0.0012133669 7.943310e-01 8.929231e-01 17 75978965 75979523 559 - 1.484 1.476 -0.029
ENSG00000161533 E038 0.3559677 0.4617945449 6.148362e-01   17 75979788 75979871 84 - 0.166 0.000 -9.358