ENSG00000161203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292807 ENSG00000161203 HEK293_OSMI2_6hA HEK293_TMG_6hB AP2M1 protein_coding protein_coding 263.6527 313.1532 175.7289 56.02011 8.881148 -0.8334812 203.256854 250.877358 120.70002 46.761919 6.236228 -1.055494 0.75559167 0.798333333 0.68683333 -0.11150000 0.0001457502 2.078846e-05 FALSE TRUE
ENST00000382456 ENSG00000161203 HEK293_OSMI2_6hA HEK293_TMG_6hB AP2M1 protein_coding protein_coding 263.6527 313.1532 175.7289 56.02011 8.881148 -0.8334812 27.893183 37.824764 18.72685 9.791349 1.585255 -1.013834 0.11363750 0.116600000 0.10623333 -0.01036667 0.9422238213 2.078846e-05 FALSE TRUE
ENST00000476434 ENSG00000161203 HEK293_OSMI2_6hA HEK293_TMG_6hB AP2M1 protein_coding retained_intron 263.6527 313.1532 175.7289 56.02011 8.881148 -0.8334812 5.676043 3.018189 15.44972 1.958018 2.455543 2.351987 0.02872917 0.009333333 0.08733333 0.07800000 0.3645438208 2.078846e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000161203 E001 0.1426347 3.166028e-02 2.137995e-01   3 184174689 184174796 108 + 0.172 0.000 -10.350
ENSG00000161203 E002 2.6126113 8.071720e-02 1.412326e-01 0.3493489523 3 184174797 184174845 49 + 0.295 0.618 1.693
ENSG00000161203 E003 3.2384975 2.003417e-02 1.111689e-01 0.3009089137 3 184174846 184174848 3 + 0.391 0.683 1.390
ENSG00000161203 E004 3.4709715 4.000056e-02 3.229471e-02 0.1340958272 3 184174849 184174852 4 + 0.295 0.719 2.121
ENSG00000161203 E005 3.4709715 4.000056e-02 3.229471e-02 0.1340958272 3 184174853 184174854 2 + 0.295 0.719 2.121
ENSG00000161203 E006 3.4709715 4.000056e-02 3.229471e-02 0.1340958272 3 184174855 184174855 1 + 0.295 0.719 2.121
ENSG00000161203 E007 135.1777755 1.192909e-03 8.868364e-01 0.9450426411 3 184174856 184174881 26 + 2.093 2.100 0.024
ENSG00000161203 E008 319.8015814 1.173536e-03 3.396789e-01 0.5777136629 3 184174882 184174904 23 + 2.449 2.478 0.095
ENSG00000161203 E009 456.0226185 1.795243e-03 8.231512e-01 0.9097803197 3 184174905 184174916 12 + 2.625 2.622 -0.009
ENSG00000161203 E010 501.3358049 2.038200e-03 2.786545e-01 0.5187388050 3 184174917 184174924 8 + 2.683 2.656 -0.090
ENSG00000161203 E011 644.6319523 8.903093e-04 6.954390e-01 0.8325218048 3 184174925 184174948 24 + 2.765 2.776 0.038
ENSG00000161203 E012 666.5977734 9.362086e-04 7.998083e-01 0.8962514816 3 184174949 184174959 11 + 2.781 2.790 0.028
ENSG00000161203 E013 4.7389206 7.495578e-03 2.186791e-02 0.1021334625 3 184174960 184175110 151 + 0.918 0.602 -1.279
ENSG00000161203 E014 5.7257384 7.605514e-02 8.378027e-01 0.9182021005 3 184176778 184176950 173 + 0.832 0.787 -0.174
ENSG00000161203 E015 792.9277155 6.898797e-04 7.360501e-01 0.8579909000 3 184176951 184176978 28 + 2.865 2.861 -0.012
ENSG00000161203 E016 1245.6335664 7.139079e-04 4.525540e-01 0.6675533736 3 184176979 184177067 89 + 3.065 3.054 -0.035
ENSG00000161203 E017 1.2782695 1.358806e-02 6.751059e-02   3 184177543 184177611 69 + 0.535 0.215 -1.921
ENSG00000161203 E018 1.5571215 2.773280e-01 6.761582e-01 0.8202998553 3 184177612 184178217 606 + 0.465 0.357 -0.588
ENSG00000161203 E019 0.1723744 4.094390e-02 1.000000e+00   3 184178218 184178223 6 + 0.000 0.084 10.088
ENSG00000161203 E020 2722.6036485 3.780840e-05 7.204954e-02 0.2289094613 3 184178857 184179122 266 + 3.403 3.392 -0.039
ENSG00000161203 E021 2.9408980 7.589695e-03 5.232848e-05 0.0008651266 3 184179123 184179191 69 + 0.893 0.269 -2.990
ENSG00000161203 E022 13.1063772 2.291784e-01 8.145905e-02 0.2477323174 3 184179192 184180063 872 + 1.318 0.984 -1.199
ENSG00000161203 E023 6.7053794 1.739039e-02 5.288354e-01 0.7211940768 3 184180064 184180168 105 + 0.918 0.831 -0.336
ENSG00000161203 E024 1578.3903665 5.444219e-05 3.667388e-04 0.0044051974 3 184180169 184180237 69 + 3.182 3.148 -0.111
ENSG00000161203 E025 1140.6110017 8.943769e-05 2.106715e-06 0.0000546462 3 184180238 184180251 14 + 3.055 3.001 -0.180
ENSG00000161203 E026 19.5779899 2.022187e-01 8.667898e-02 0.2576673853 3 184180252 184180561 310 + 1.480 1.148 -1.160
ENSG00000161203 E027 179.4923732 2.436647e-03 1.155614e-05 0.0002374470 3 184180562 184180644 83 + 2.324 2.166 -0.528
ENSG00000161203 E028 764.4440475 7.746944e-04 1.256273e-04 0.0018070290 3 184180645 184180650 6 + 2.894 2.823 -0.236
ENSG00000161203 E029 6.5970324 1.321810e-01 6.453827e-03 0.0419460473 3 184180651 184180741 91 + 1.140 0.606 -2.076
ENSG00000161203 E030 14.0377742 1.185121e-01 1.502302e-01 0.3626599916 3 184180742 184180848 107 + 1.302 1.042 -0.926
ENSG00000161203 E031 1396.2144236 1.149543e-04 2.198175e-01 0.4532767505 3 184180849 184180881 33 + 3.114 3.102 -0.038
ENSG00000161203 E032 2029.0656606 5.807960e-05 2.226252e-02 0.1034756102 3 184180882 184180984 103 + 3.252 3.274 0.075
ENSG00000161203 E033 14.8216440 6.554137e-02 5.075073e-01 0.7060265178 3 184180985 184181084 100 + 1.072 1.184 0.402
ENSG00000161203 E034 1380.2190706 2.596776e-04 2.165303e-03 0.0181777772 3 184181085 184181124 40 + 3.071 3.112 0.138
ENSG00000161203 E035 1031.2601689 6.387910e-04 2.211336e-01 0.4548501993 3 184181125 184181125 1 + 2.958 2.981 0.076
ENSG00000161203 E036 1701.8453874 4.608304e-04 2.091941e-03 0.0176807659 3 184181126 184181194 69 + 3.159 3.205 0.152
ENSG00000161203 E037 1374.8682124 1.115561e-04 4.980723e-02 0.1791694929 3 184181195 184181226 32 + 3.081 3.105 0.081
ENSG00000161203 E038 44.3643906 1.492411e-01 9.303498e-02 0.2693548843 3 184181227 184181695 469 + 1.793 1.516 -0.942
ENSG00000161203 E039 1162.8424269 1.229286e-04 5.783412e-01 0.7560217830 3 184181696 184181711 16 + 3.030 3.025 -0.016
ENSG00000161203 E040 1950.0432380 8.165410e-04 7.598545e-01 0.8724666330 3 184181712 184181815 104 + 3.244 3.255 0.037
ENSG00000161203 E041 14.2539581 5.856821e-02 2.564289e-02 0.1142004194 3 184181816 184181911 96 + 1.342 1.023 -1.137
ENSG00000161203 E042 2536.2688063 5.052533e-04 5.531218e-02 0.1920209347 3 184181912 184182047 136 + 3.378 3.359 -0.063
ENSG00000161203 E043 149.5024929 9.195148e-03 3.255582e-01 0.5647760443 3 184182048 184182080 33 + 2.168 2.121 -0.156
ENSG00000161203 E044 12.7870362 4.561393e-02 7.390931e-01 0.8598427518 3 184182123 184182150 28 + 1.120 1.081 -0.140
ENSG00000161203 E045 2235.5266536 3.265609e-04 3.422903e-01 0.5800218506 3 184182151 184182248 98 + 3.315 3.308 -0.023
ENSG00000161203 E046 44.0148019 1.364064e-01 1.387834e-01 0.3456488025 3 184182249 184182756 508 + 1.764 1.532 -0.787
ENSG00000161203 E047 2164.5792653 3.809391e-04 8.366813e-01 0.9176482230 3 184182757 184182868 112 + 3.291 3.298 0.025
ENSG00000161203 E048 73.2260039 4.170284e-02 6.975958e-04 0.0074251211 3 184182869 184182955 87 + 2.055 1.685 -1.245
ENSG00000161203 E049 159.3385875 7.443557e-02 5.789868e-03 0.0386934686 3 184182956 184183481 526 + 2.385 2.025 -1.205
ENSG00000161203 E050 2192.7934095 1.359305e-03 4.432729e-02 0.1659112440 3 184183482 184183647 166 + 3.270 3.317 0.156
ENSG00000161203 E051 2597.8113280 1.376724e-03 6.260247e-06 0.0001398676 3 184183648 184184214 567 + 3.310 3.403 0.309