ENSG00000160867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292408 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding protein_coding 15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 1.6480474 2.3344878 1.6836438 0.5171787 1.0273854 -0.4691422512 0.10575000 0.11226667 0.14730000 0.035033333 9.776489e-01 7.859103e-11 FALSE TRUE
ENST00000426612 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding retained_intron 15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 0.8595217 1.0558412 1.0555909 0.2424666 0.2055315 -0.0003388316 0.05955000 0.05066667 0.09110000 0.040433333 5.102457e-01 7.859103e-11 FALSE TRUE
ENST00000502906 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding protein_coding 15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 2.8336739 4.5824620 2.2737954 1.5954096 1.2332560 -1.0078344158 0.18346250 0.21896667 0.19676667 -0.022200000 9.550794e-01 7.859103e-11 FALSE TRUE
ENST00000508139 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding retained_intron 15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 0.8869441 1.3380365 1.0751846 0.3396138 0.3306415 -0.3129190931 0.05787083 0.06400000 0.09200000 0.028000000 8.766787e-01 7.859103e-11 FALSE FALSE
MSTRG.27375.1 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding   15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 2.0812800 2.7141023 1.6293940 0.3040423 0.4030348 -0.7326182656 0.13899167 0.13153333 0.14106667 0.009533333 9.952256e-01 7.859103e-11 FALSE TRUE
MSTRG.27375.3 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding   15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 1.9407798 2.9492845 0.0000000 0.7561463 0.0000000 -8.2091045666 0.12062917 0.13870000 0.00000000 -0.138700000 7.859103e-11 7.859103e-11 FALSE TRUE
MSTRG.27375.5 ENSG00000160867 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR4 protein_coding   15.33904 20.77855 11.52162 1.333715 0.3148827 -0.850194 0.8316598 0.9192219 0.7777986 0.4080072 0.3417485 -0.2381963203 0.05525417 0.04456667 0.06876667 0.024200000 9.297869e-01 7.859103e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160867 E001 0.7379733 0.0191671551 0.6736740028   5 177086867 177086873 7 + 0.180 0.258 0.667
ENSG00000160867 E002 2.2901552 0.0098123376 0.1700651464 0.390534183 5 177086874 177086882 9 + 0.306 0.561 1.371
ENSG00000160867 E003 2.5518915 0.0266356868 0.1228795915 0.320283956 5 177086883 177086883 1 + 0.306 0.605 1.566
ENSG00000160867 E004 2.5518915 0.0266356868 0.1228795915 0.320283956 5 177086884 177086884 1 + 0.306 0.605 1.566
ENSG00000160867 E005 11.5905841 0.0037595222 0.8416793622 0.920425221 5 177086885 177086897 13 + 1.050 1.071 0.076
ENSG00000160867 E006 15.9272719 0.0050986255 0.7675902233 0.877175870 5 177086898 177086904 7 + 1.171 1.199 0.101
ENSG00000160867 E007 19.8056462 0.0034649291 0.8066862184 0.900126639 5 177086905 177086913 9 + 1.264 1.285 0.072
ENSG00000160867 E008 20.1262647 0.0030814917 0.9811778832 0.992370570 5 177086914 177086914 1 + 1.288 1.285 -0.010
ENSG00000160867 E009 20.6802848 0.0067699638 0.9739974663 0.988865253 5 177086915 177086915 1 + 1.300 1.297 -0.010
ENSG00000160867 E010 54.1437494 0.0007691137 0.3244204986 0.563720159 5 177086916 177087018 103 + 1.662 1.713 0.173
ENSG00000160867 E011 36.0985386 0.0010501457 0.7478497625 0.865413928 5 177087019 177087033 15 + 1.541 1.518 -0.076
ENSG00000160867 E012 17.8683598 0.0429397655 0.7645664045 0.875351989 5 177087034 177087077 44 + 1.268 1.216 -0.182
ENSG00000160867 E013 0.5117739 0.0226250731 0.1780024657   5 177087419 177087635 217 + 0.306 0.081 -2.326
ENSG00000160867 E014 0.8571428 0.0172344464 0.1514858045   5 177088239 177088514 276 + 0.404 0.149 -1.908
ENSG00000160867 E015 40.8097169 0.0014403613 0.4981320824 0.699567077 5 177089550 177089557 8 + 1.606 1.562 -0.150
ENSG00000160867 E016 41.4549795 0.0010233017 0.6579001384 0.808599185 5 177089558 177089566 9 + 1.565 1.590 0.084
ENSG00000160867 E017 40.5148041 0.0013415041 0.2975253297 0.538049029 5 177089567 177089575 9 + 1.527 1.590 0.214
ENSG00000160867 E018 43.3747374 0.0010798468 0.2069300414 0.438096597 5 177089576 177089597 22 + 1.547 1.621 0.252
ENSG00000160867 E019 37.3657052 0.0012176108 0.1253820987 0.324436449 5 177089598 177089602 5 + 1.464 1.562 0.336
ENSG00000160867 E020 63.6762282 0.0006573562 0.5498211862 0.736149601 5 177089603 177089693 91 + 1.746 1.773 0.092
ENSG00000160867 E021 7.1701526 0.1323500412 0.6163919502 0.781327199 5 177089858 177089940 83 + 0.933 0.851 -0.314
ENSG00000160867 E022 7.5908044 0.0085178081 0.0659475375 0.216053434 5 177090335 177090389 55 + 1.050 0.825 -0.845
ENSG00000160867 E023 100.6608850 0.0004448959 0.0152563778 0.079031322 5 177090390 177090653 264 + 2.028 1.935 -0.312
ENSG00000160867 E024 71.0363726 0.0006479961 0.0002463429 0.003179411 5 177090745 177090825 81 + 1.926 1.762 -0.551
ENSG00000160867 E025 11.0811876 0.0264868397 0.0839254881 0.252627367 5 177090826 177090937 112 + 1.186 0.969 -0.787
ENSG00000160867 E026 97.9666218 0.0013393357 0.0042057961 0.030296539 5 177090938 177091104 167 + 2.032 1.913 -0.400
ENSG00000160867 E027 73.5907108 0.0109695209 0.7932228266 0.892305383 5 177091685 177091777 93 + 1.844 1.819 -0.085
ENSG00000160867 E028 43.2358598 0.0023514604 0.5371630617 0.727101160 5 177091778 177091808 31 + 1.578 1.615 0.127
ENSG00000160867 E029 99.4396553 0.0004454374 0.0343972635 0.139965173 5 177092321 177092511 191 + 1.901 1.984 0.279
ENSG00000160867 E030 109.0867403 0.0004589270 0.3604946543 0.596074871 5 177092646 177092784 139 + 1.978 2.011 0.111
ENSG00000160867 E031 8.8712802 0.1748383570 0.1488219411 0.360646544 5 177092785 177093068 284 + 1.146 0.838 -1.142
ENSG00000160867 E032 59.4489049 0.0008996970 0.6273058655 0.788750168 5 177093138 177093174 37 + 1.725 1.749 0.080
ENSG00000160867 E033 42.4916722 0.0012016772 0.7312172276 0.854910798 5 177093175 177093177 3 + 1.583 1.603 0.066
ENSG00000160867 E034 79.1457855 0.0029837651 0.7619519292 0.873784253 5 177093178 177093331 154 + 1.852 1.865 0.042
ENSG00000160867 E035 22.1984930 0.0057209351 0.0185200802 0.090784424 5 177093332 177093405 74 + 1.449 1.249 -0.693
ENSG00000160867 E036 47.2037004 0.0015971618 0.9117870973 0.958044262 5 177093406 177093417 12 + 1.643 1.633 -0.031
ENSG00000160867 E037 89.0107006 0.0005906331 0.3085204202 0.549086809 5 177093418 177093501 84 + 1.939 1.894 -0.149
ENSG00000160867 E038 76.3669140 0.0011859078 0.0832427054 0.251267052 5 177093502 177093551 50 + 1.899 1.817 -0.275
ENSG00000160867 E039 124.2537480 0.0004071589 0.1246951885 0.323259923 5 177093654 177093775 122 + 2.092 2.037 -0.183
ENSG00000160867 E040 0.9279113 0.0156657090 0.0569946531   5 177094825 177095329 505 + 0.483 0.148 -2.326
ENSG00000160867 E041 118.2642117 0.0003958208 0.5907620070 0.764232439 5 177095330 177095440 111 + 2.020 2.037 0.058
ENSG00000160867 E042 135.1458478 0.0004639714 0.3086241838 0.549150625 5 177095533 177095723 191 + 2.068 2.100 0.109
ENSG00000160867 E043 84.8935385 0.0166447242 0.8930834737 0.948193302 5 177096057 177096179 123 + 1.889 1.892 0.009
ENSG00000160867 E044 75.8974067 0.0078351691 0.7006560894 0.836044456 5 177096287 177096357 71 + 1.862 1.836 -0.090
ENSG00000160867 E045 105.1141990 0.0013850446 0.7525075897 0.868265796 5 177096604 177096741 138 + 1.978 1.990 0.041
ENSG00000160867 E046 0.7035494 0.0307016994 0.0607493722   5 177097191 177097291 101 + 0.404 0.081 -2.909
ENSG00000160867 E047 111.6252476 0.0004344093 0.0133914419 0.071994898 5 177097292 177097397 106 + 1.944 2.036 0.310
ENSG00000160867 E048 224.8267728 0.0002970439 0.0012368860 0.011694635 5 177097527 177098144 618 + 2.251 2.335 0.280