ENSG00000160746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292246 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding protein_coding 21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 2.324688 2.2457351 2.0831327 0.09992773 0.5625672 -0.10793386 0.11080000 0.14250000 0.08160000 -0.06090000 6.230439e-01 5.467586e-09 FALSE TRUE
ENST00000350459 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding protein_coding 21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 3.762813 3.8968995 3.7502742 0.62843853 0.5948828 -0.05518626 0.17856250 0.22756667 0.14873333 -0.07883333 4.221748e-01 5.467586e-09 FALSE TRUE
ENST00000396091 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding protein_coding 21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 8.718341 7.0415801 9.3348619 1.83891426 0.7357008 0.40622678 0.40384167 0.39070000 0.36856667 -0.02213333 9.380990e-01 5.467586e-09 FALSE TRUE
ENST00000414522 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding protein_coding 21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 1.161616 0.3432657 1.9352378 0.34326566 0.5563506 2.46112113 0.04937083 0.01883333 0.07613333 0.05730000 3.040915e-01 5.467586e-09 FALSE TRUE
ENST00000427171 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding protein_coding 21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 1.724303 0.0000000 4.7339711 0.00000000 1.4193553 8.88995141 0.07043333 0.00000000 0.18550000 0.18550000 5.467586e-09 5.467586e-09 FALSE FALSE
MSTRG.22801.6 ENSG00000160746 HEK293_OSMI2_6hA HEK293_TMG_6hB ANO10 protein_coding   21.70131 17.57211 25.34401 3.677593 0.3794857 0.5281061 1.165746 1.2474156 0.5487707 0.25967900 0.2231642 -1.17013312 0.05557500 0.07096667 0.02140000 -0.04956667 1.200684e-01 5.467586e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160746 E001 1.2124903 0.7036576229 8.028141e-01   3 43354859 43355056 198 - 0.360 0.310 -0.308
ENSG00000160746 E002 1.8510210 0.0240220965 1.244140e-01 3.227795e-01 3 43365837 43365847 11 - 0.577 0.303 -1.456
ENSG00000160746 E003 10.3919507 0.0769508552 6.696932e-01 8.160944e-01 3 43365848 43366347 500 - 1.031 1.086 0.199
ENSG00000160746 E004 7.4955667 0.0075018484 4.685129e-02 1.721909e-01 3 43366348 43366358 11 - 0.795 1.033 0.902
ENSG00000160746 E005 100.5057980 0.0004394960 1.295419e-03 1.212879e-02 3 43366359 43366555 197 - 1.946 2.062 0.386
ENSG00000160746 E006 88.8364854 0.0005381111 2.285753e-03 1.895934e-02 3 43366556 43366612 57 - 1.893 2.010 0.393
ENSG00000160746 E007 61.8987511 0.0043897730 5.634085e-03 3.791133e-02 3 43366613 43366642 30 - 1.719 1.871 0.514
ENSG00000160746 E008 144.7593127 0.0003245276 4.412056e-11 3.364475e-09 3 43366643 43366888 246 - 2.057 2.253 0.655
ENSG00000160746 E009 108.3807621 0.0004705691 2.279702e-02 1.053000e-01 3 43366889 43366974 86 - 1.997 2.075 0.265
ENSG00000160746 E010 0.3751086 0.0271065452 1.761900e-01   3 43372728 43372847 120 - 0.000 0.224 10.819
ENSG00000160746 E011 122.5170906 0.0080997712 5.117335e-02 1.825035e-01 3 43432611 43432727 117 - 2.030 2.142 0.374
ENSG00000160746 E012 144.0913358 0.0041054817 5.097123e-01 7.077692e-01 3 43549720 43549848 129 - 2.143 2.177 0.116
ENSG00000160746 E013 6.0891582 0.0411264158 4.366249e-01 6.561912e-01 3 43551472 43551588 117 - 0.773 0.896 0.480
ENSG00000160746 E014 177.0704489 0.0002517239 5.200321e-01 7.150074e-01 3 43555278 43555469 192 - 2.240 2.258 0.060
ENSG00000160746 E015 144.3081184 0.0013528866 4.746984e-01 6.833492e-01 3 43561220 43561372 153 - 2.145 2.170 0.084
ENSG00000160746 E016 77.5011036 0.0020013216 8.019534e-01 8.975025e-01 3 43561373 43561402 30 - 1.883 1.896 0.043
ENSG00000160746 E017 91.2169773 0.0005352604 3.121543e-01 5.524687e-01 3 43565653 43565727 75 - 1.942 1.981 0.132
ENSG00000160746 E018 2.7567188 0.0079321635 1.842281e-02 9.044075e-02 3 43566083 43566279 197 - 0.349 0.731 1.826
ENSG00000160746 E019 72.1746575 0.0011045502 9.477594e-01 9.761862e-01 3 43574809 43574864 56 - 1.863 1.868 0.015
ENSG00000160746 E020 176.3460313 0.0002741714 6.734683e-01 8.185863e-01 3 43576692 43577034 343 - 2.254 2.244 -0.033
ENSG00000160746 E021 144.7232382 0.0009337537 3.720071e-01 6.056001e-01 3 43577035 43577261 227 - 2.174 2.147 -0.091
ENSG00000160746 E022 109.1850508 0.0004291258 5.729366e-02 1.966884e-01 3 43580353 43580472 120 - 2.070 2.006 -0.213
ENSG00000160746 E023 85.9913244 0.0006321864 7.277023e-03 4.596466e-02 3 43598532 43598564 33 - 1.990 1.887 -0.344
ENSG00000160746 E024 80.1683293 0.0005133360 1.975104e-02 9.505217e-02 3 43598565 43598580 16 - 1.952 1.862 -0.305
ENSG00000160746 E025 68.0669346 0.0005875797 1.097609e-02 6.226801e-02 3 43598581 43598581 1 - 1.888 1.780 -0.364
ENSG00000160746 E026 87.5227445 0.0005340545 4.585284e-05 7.725833e-04 3 43598582 43598601 20 - 2.016 1.862 -0.520
ENSG00000160746 E027 106.2528680 0.0013249856 3.075872e-04 3.806688e-03 3 43598602 43598666 65 - 2.092 1.958 -0.448
ENSG00000160746 E028 139.1961537 0.0048354655 2.637292e-03 2.119607e-02 3 43600384 43600581 198 - 2.208 2.076 -0.442
ENSG00000160746 E029 59.6051282 0.0011723221 1.138090e-02 6.393236e-02 3 43605714 43605736 23 - 1.835 1.715 -0.403
ENSG00000160746 E030 90.3221002 0.0005601979 2.984513e-04 3.713922e-03 3 43605737 43605863 127 - 2.021 1.886 -0.456
ENSG00000160746 E031 0.1308682 0.0307364445 4.475150e-01   3 43618020 43618086 67 - 0.000 0.126 9.812
ENSG00000160746 E032 0.5963342 0.0234886512 3.560096e-01   3 43621773 43621908 136 - 0.285 0.126 -1.461
ENSG00000160746 E033 39.6375272 0.0009354139 3.169495e-02 1.323191e-01 3 43621909 43622066 158 - 1.663 1.544 -0.405
ENSG00000160746 E034 2.7066002 0.3617888192 1.118957e-01 3.022521e-01 3 43636309 43636538 230 - 0.281 0.773 2.435
ENSG00000160746 E035 3.2835153 0.0146039411 5.089957e-04 5.761843e-03 3 43637603 43637783 181 - 0.285 0.848 2.707
ENSG00000160746 E036 0.8098394 0.0169633060 1.456739e-01   3 43638675 43639083 409 - 0.117 0.371 2.127
ENSG00000160746 E037 3.0825666 0.0437314045 1.371502e-01 3.431797e-01 3 43652947 43653037 91 - 0.455 0.708 1.148
ENSG00000160746 E038 2.0588466 0.0141661477 4.718648e-01 6.814226e-01 3 43653038 43653040 3 - 0.406 0.527 0.616
ENSG00000160746 E039 1.7940938 0.0845362574 6.973610e-01 8.338326e-01 3 43689311 43689476 166 - 0.407 0.480 0.379
ENSG00000160746 E040 1.0121411 0.0964137035 9.055131e-02   3 43690541 43690614 74 - 0.117 0.431 2.458
ENSG00000160746 E041 0.8397668 0.0182685335 1.436084e-01   3 43690615 43690819 205 - 0.117 0.371 2.127
ENSG00000160746 E042 3.3411666 0.0077355148 2.883986e-01 5.291349e-01 3 43691517 43691594 78 - 0.540 0.703 0.712