ENSG00000160584

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000445177 ENSG00000160584 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK3 protein_coding protein_coding 8.976805 11.73242 8.721406 0.6758193 0.64374 -0.4274443 4.5224817 5.8323037 4.5054984 0.3821576 0.08241791 -0.3716521 0.50960000 0.49843333 0.52083333 0.02240000 0.94762094 0.01898595 FALSE TRUE
ENST00000446921 ENSG00000160584 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK3 protein_coding protein_coding 8.976805 11.73242 8.721406 0.6758193 0.64374 -0.4274443 1.3357513 1.8343061 1.5828791 0.2806344 0.13991355 -0.2114413 0.15373333 0.15470000 0.18156667 0.02686667 0.82830371 0.01898595 FALSE TRUE
ENST00000488337 ENSG00000160584 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK3 protein_coding processed_transcript 8.976805 11.73242 8.721406 0.6758193 0.64374 -0.4274443 1.1061377 1.3390157 0.1104730 0.3927855 0.08211931 -3.4851258 0.11446250 0.11230000 0.01153333 -0.10076667 0.01898595 0.01898595 FALSE TRUE
MSTRG.6362.4 ENSG00000160584 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK3 protein_coding   8.976805 11.73242 8.721406 0.6758193 0.64374 -0.4274443 0.1494474 0.3659916 0.8295879 0.2060896 0.21974780 1.1589810 0.01616667 0.03166667 0.09766667 0.06600000 0.58747079 0.01898595 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160584 E001 0.1308682 0.0310079379 7.654133e-01   11 116843402 116843414 13 - 0.000 0.097 8.966
ENSG00000160584 E002 250.5563135 0.0002326278 3.871352e-04 0.0046065344 11 116843415 116845029 1615 - 2.331 2.412 0.270
ENSG00000160584 E003 61.9452968 0.0006400034 5.889446e-03 0.0391975005 11 116845030 116845183 154 - 1.699 1.829 0.439
ENSG00000160584 E004 41.1708942 0.0059883100 4.048569e-02 0.1559896564 11 116845184 116845250 67 - 1.518 1.655 0.470
ENSG00000160584 E005 72.9841217 0.0054843467 1.435778e-01 0.3527657991 11 116845251 116845411 161 - 1.796 1.877 0.274
ENSG00000160584 E006 110.7314594 0.0004201429 1.306011e-01 0.3327342667 11 116845412 116845592 181 - 1.996 2.048 0.175
ENSG00000160584 E007 56.2381902 0.0007106524 6.742309e-02 0.2192938808 11 116845593 116845629 37 - 1.684 1.774 0.303
ENSG00000160584 E008 70.7965460 0.0005645583 2.211052e-02 0.1029550919 11 116846383 116846457 75 - 1.775 1.875 0.338
ENSG00000160584 E009 91.7896744 0.0006249941 2.262436e-03 0.0188110151 11 116846458 116846553 96 - 1.870 1.990 0.404
ENSG00000160584 E010 108.7869262 0.0004654361 3.423641e-02 0.1395045296 11 116847476 116847608 133 - 1.973 2.048 0.251
ENSG00000160584 E011 114.6470044 0.0004110606 7.714861e-02 0.2390891576 11 116849120 116849283 164 - 2.008 2.068 0.202
ENSG00000160584 E012 3.5629851 0.0174942575 1.934739e-01 0.4214468947 11 116856914 116857809 896 - 0.488 0.702 0.956
ENSG00000160584 E013 221.7070121 0.0002702330 2.030846e-02 0.0969675043 11 116857810 116858519 710 - 2.296 2.352 0.188
ENSG00000160584 E014 49.4114689 0.0033678900 8.402517e-01 0.9195860406 11 116858520 116858699 180 - 1.684 1.696 0.042
ENSG00000160584 E015 102.3363396 0.0137414713 7.817117e-01 0.8856460002 11 116859265 116859604 340 - 2.013 1.990 -0.077
ENSG00000160584 E016 54.6172938 0.0006570180 7.991483e-01 0.8957885890 11 116861274 116861383 110 - 1.737 1.724 -0.045
ENSG00000160584 E017 0.1779838 0.0340447722 3.003319e-01   11 116861384 116861384 1 - 0.151 0.000 -13.166
ENSG00000160584 E018 43.5686600 0.0008546551 1.680256e-01 0.3879452275 11 116861841 116861926 86 - 1.677 1.601 -0.258
ENSG00000160584 E019 47.4808135 0.0007986562 2.334604e-01 0.4691168398 11 116862202 116862327 126 - 1.710 1.647 -0.212
ENSG00000160584 E020 71.4116820 0.0010359041 6.812861e-01 0.8234627592 11 116863668 116863818 151 - 1.857 1.838 -0.063
ENSG00000160584 E021 11.3147409 0.0786537182 2.024692e-01 0.4327144893 11 116863819 116865068 1250 - 1.185 0.992 -0.702
ENSG00000160584 E022 2.1289950 0.0253396790 9.562951e-01 0.9800484881 11 116867688 116867945 258 - 0.488 0.478 -0.047
ENSG00000160584 E023 71.1857540 0.0035242209 8.902835e-02 0.2619425265 11 116867946 116868089 144 - 1.896 1.813 -0.282
ENSG00000160584 E024 15.0427849 0.0047794984 2.331391e-01 0.4687874685 11 116868792 116870140 1349 - 1.256 1.147 -0.386
ENSG00000160584 E025 8.7870735 0.0038602024 7.148966e-01 0.8448624239 11 116870141 116870330 190 - 0.949 0.990 0.152
ENSG00000160584 E026 57.2377642 0.0011135792 7.245615e-02 0.2297001864 11 116870331 116870401 71 - 1.804 1.717 -0.295
ENSG00000160584 E027 81.7506003 0.0004759764 9.541303e-03 0.0561543115 11 116873481 116873636 156 - 1.963 1.860 -0.348
ENSG00000160584 E028 0.0000000       11 116873637 116873672 36 -      
ENSG00000160584 E029 68.8866276 0.0005569018 5.321639e-01 0.7235942522 11 116873903 116874039 137 - 1.847 1.819 -0.094
ENSG00000160584 E030 36.1661132 0.0011884285 8.833289e-01 0.9430115981 11 116874040 116874056 17 - 1.550 1.558 0.027
ENSG00000160584 E031 62.2069162 0.0007050977 2.275705e-01 0.4624455167 11 116875158 116875267 110 - 1.821 1.765 -0.189
ENSG00000160584 E032 55.7254415 0.0009255691 2.424415e-01 0.4792696258 11 116875374 116875451 78 - 1.775 1.717 -0.195
ENSG00000160584 E033 0.3336024 0.0244411696 3.730458e-01   11 116875452 116875513 62 - 0.000 0.177 12.543
ENSG00000160584 E034 55.7810323 0.0011461494 6.156280e-02 0.2063078346 11 116875866 116876009 144 - 1.790 1.697 -0.315
ENSG00000160584 E035 71.9318833 0.0006400012 1.376765e-01 0.3439584183 11 116876253 116876363 111 - 1.884 1.819 -0.217
ENSG00000160584 E036 62.8651711 0.0008052543 8.142380e-02 0.2476605911 11 116876924 116877042 119 - 1.837 1.756 -0.273
ENSG00000160584 E037 3.1049343 0.0418723407 5.062174e-01 0.7051045863 11 116893845 116893967 123 - 0.541 0.652 0.495
ENSG00000160584 E038 55.8279152 0.0007647344 2.753277e-01 0.5153663899 11 116896253 116896376 124 - 1.775 1.721 -0.181
ENSG00000160584 E039 50.8575746 0.0015439724 3.534610e-01 0.5903868377 11 116897193 116897317 125 - 1.733 1.684 -0.166
ENSG00000160584 E040 0.0000000       11 116904746 116905003 258 -      
ENSG00000160584 E041 63.1338734 0.0008638163 4.824787e-02 0.1755871226 11 116927219 116927380 162 - 1.850 1.759 -0.306
ENSG00000160584 E042 0.7608862 0.0845951298 9.326711e-01   11 116950133 116950256 124 - 0.261 0.243 -0.136
ENSG00000160584 E043 40.4846628 0.0010430030 1.458425e-04 0.0020490943 11 116954044 116954107 64 - 1.727 1.516 -0.717
ENSG00000160584 E044 44.5016207 0.0013119425 7.037189e-06 0.0001544825 11 116956948 116957064 117 - 1.778 1.536 -0.823
ENSG00000160584 E045 27.3687604 0.0020452612 1.611641e-03 0.0144094869 11 117098143 117098437 295 - 1.555 1.339 -0.744