ENSG00000160445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291900 ENSG00000160445 HEK293_OSMI2_6hA HEK293_TMG_6hB ZER1 protein_coding protein_coding 24.34849 35.56003 15.08372 6.999534 1.263712 -1.236714 12.6065815 21.948791 7.2938587 4.3975365 0.2821143 -1.5880679 0.50819167 0.61603333 0.48800000 -0.128033333 0.1792948087 0.0001683013 FALSE TRUE
ENST00000414921 ENSG00000160445 HEK293_OSMI2_6hA HEK293_TMG_6hB ZER1 protein_coding protein_coding 24.34849 35.56003 15.08372 6.999534 1.263712 -1.236714 0.8128362 0.000000 0.9272493 0.0000000 0.9272493 6.5503609 0.04270833 0.00000000 0.05270000 0.052700000 0.7864590871 0.0001683013 FALSE FALSE
MSTRG.33469.3 ENSG00000160445 HEK293_OSMI2_6hA HEK293_TMG_6hB ZER1 protein_coding   24.34849 35.56003 15.08372 6.999534 1.263712 -1.236714 3.8874078 4.948424 0.4491963 1.1814344 0.4491963 -3.4326987 0.13526250 0.14436667 0.03193333 -0.112433333 0.2315679953 0.0001683013 FALSE TRUE
MSTRG.33469.7 ENSG00000160445 HEK293_OSMI2_6hA HEK293_TMG_6hB ZER1 protein_coding   24.34849 35.56003 15.08372 6.999534 1.263712 -1.236714 1.3187396 1.965174 0.8396725 0.5118465 0.5358538 -1.2170012 0.05647500 0.05356667 0.05153333 -0.002033333 0.9052019723 0.0001683013 FALSE TRUE
MSTRG.33469.9 ENSG00000160445 HEK293_OSMI2_6hA HEK293_TMG_6hB ZER1 protein_coding   24.34849 35.56003 15.08372 6.999534 1.263712 -1.236714 3.6208463 4.412482 4.0985693 0.6929200 0.5280844 -0.1062202 0.16538750 0.12696667 0.27030000 0.143333333 0.0001683013 0.0001683013 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160445 E001 0.1779838 0.0356964244 1.569617e-01   9 128729663 128729714 52 - 0.192 0.000 -12.692
ENSG00000160445 E002 0.3559677 0.4842619881 9.385689e-02   9 128729715 128729785 71 - 0.330 0.000 -13.745
ENSG00000160445 E003 59.9088534 0.0008381158 3.237338e-01 0.5630443782 9 128729786 128729872 87 - 1.682 1.742 0.205
ENSG00000160445 E004 77.9230675 0.0009616746 4.426325e-02 0.1657790185 9 128729873 128729896 24 - 1.759 1.865 0.358
ENSG00000160445 E005 91.6465210 0.0006531894 1.083197e-02 0.0616590471 9 128729897 128729933 37 - 1.814 1.936 0.411
ENSG00000160445 E006 97.4148663 0.0020441057 5.492637e-04 0.0061245968 9 128729934 128729972 39 - 1.796 1.971 0.589
ENSG00000160445 E007 1005.3647611 0.0020158164 5.078862e-06 0.0001166339 9 128729973 128731394 1422 - 2.856 2.966 0.366
ENSG00000160445 E008 219.1721807 0.0002414663 8.887818e-01 0.9460323620 9 128733426 128733528 103 - 2.276 2.287 0.038
ENSG00000160445 E009 198.3567544 0.0003591335 1.482676e-01 0.3598475107 9 128735334 128735397 64 - 2.204 2.254 0.169
ENSG00000160445 E010 151.8600593 0.0020689355 2.041890e-01 0.4349121487 9 128735398 128735431 34 - 2.081 2.141 0.200
ENSG00000160445 E011 309.1650268 0.0003094590 5.811243e-01 0.7578991199 9 128739931 128740119 189 - 2.417 2.438 0.069
ENSG00000160445 E012 260.7735300 0.0013302203 3.972972e-01 0.6261736112 9 128740772 128740887 116 - 2.369 2.351 -0.062
ENSG00000160445 E013 260.2223570 0.0026386442 7.445985e-02 0.2337121273 9 128741535 128741654 120 - 2.394 2.338 -0.187
ENSG00000160445 E014 153.7775047 0.0050266807 9.858080e-02 0.2793196186 9 128741800 128741841 42 - 2.177 2.107 -0.235
ENSG00000160445 E015 158.6653394 0.0003769300 1.601383e-02 0.0818638198 9 128742530 128742577 48 - 2.193 2.123 -0.234
ENSG00000160445 E016 242.8941491 0.0004405824 3.966919e-01 0.6257227886 9 128742578 128742745 168 - 2.337 2.321 -0.055
ENSG00000160445 E017 66.4524225 0.0028221569 7.583830e-01 0.8716066519 9 128750616 128750621 6 - 1.772 1.762 -0.036
ENSG00000160445 E018 219.7142461 0.0002405001 7.623322e-01 0.8739960513 9 128750622 128750789 168 - 2.273 2.289 0.052
ENSG00000160445 E019 200.0738121 0.0003832024 4.684517e-01 0.6790093362 9 128751122 128751268 147 - 2.255 2.240 -0.049
ENSG00000160445 E020 173.9163215 0.0003698380 1.297123e-01 0.3313897139 9 128751413 128751527 115 - 2.213 2.173 -0.134
ENSG00000160445 E021 242.4593016 0.0003077746 1.111349e-02 0.0628417240 9 128752673 128752849 177 - 2.370 2.311 -0.197
ENSG00000160445 E022 220.9111328 0.0019833736 3.077252e-02 0.1296712476 9 128753164 128753317 154 - 2.335 2.264 -0.234
ENSG00000160445 E023 154.0202005 0.0058884830 1.730114e-01 0.3944806701 9 128753318 128753415 98 - 2.173 2.111 -0.207
ENSG00000160445 E024 221.3745725 0.0005617606 1.007417e-02 0.0584799108 9 128753416 128753600 185 - 2.337 2.271 -0.220
ENSG00000160445 E025 91.3704142 0.0005327500 3.984055e-01 0.6269603277 9 128753809 128753814 6 - 1.930 1.901 -0.096
ENSG00000160445 E026 191.8453274 0.0057446792 7.701045e-02 0.2388266299 9 128753815 128753959 145 - 2.285 2.204 -0.271
ENSG00000160445 E027 223.4105112 0.0022507335 1.415869e-02 0.0749803696 9 128755408 128755659 252 - 2.350 2.269 -0.272
ENSG00000160445 E028 2.1029458 0.0428117721 1.226909e-01 0.3200088434 9 128771158 128771230 73 - 0.637 0.364 -1.347
ENSG00000160445 E029 1.5067839 0.0136968632 4.608771e-02 0.1702393179 9 128771483 128771580 98 - 0.000 0.430 12.726
ENSG00000160445 E030 108.0310769 0.0004788921 2.116752e-01 0.4437439229 9 128771581 128771814 234 - 1.936 1.993 0.194
ENSG00000160445 E031 42.1492967 0.0012451537 9.063340e-03 0.0541063565 9 128771815 128771945 131 - 1.440 1.622 0.622
ENSG00000160445 E032 0.5059767 0.0218795474 4.271605e-01   9 128772352 128772414 63 - 0.000 0.194 11.141