ENSG00000160323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371910 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding protein_coding 3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.8879072 1.2628933 0.49766962 0.2801655 0.25078323 -1.3261496 0.22073333 0.23536667 0.25876667 0.02340000 0.982748654 0.004430051 FALSE TRUE
ENST00000371929 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding protein_coding 3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.5046474 0.8464469 0.20163275 0.1801349 0.10215166 -2.0168010 0.13785000 0.15863333 0.11826667 -0.04036667 0.855530814 0.004430051 FALSE TRUE
MSTRG.33597.19 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.3273035 0.3652466 0.09732585 0.1879598 0.09732585 -1.8058413 0.08137083 0.06243333 0.06633333 0.00390000 0.888478045 0.004430051 TRUE TRUE
MSTRG.33597.2 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.5223758 0.7155090 0.26699685 0.2350818 0.02720699 -1.3891239 0.15433333 0.12766667 0.14970000 0.02203333 0.938579159 0.004430051 FALSE TRUE
MSTRG.33597.21 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.2095990 0.4457376 0.00000000 0.1376350 0.00000000 -5.5101316 0.05068750 0.08210000 0.00000000 -0.08210000 0.004430051 0.004430051 FALSE TRUE
MSTRG.33597.3 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.2293515 0.5397781 0.18178552 0.1125582 0.06059317 -1.5193555 0.06612500 0.11743333 0.09763333 -0.01980000 0.987744914 0.004430051 TRUE TRUE
MSTRG.33597.4 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.2259302 0.3977693 0.10613999 0.1537832 0.06011855 -1.8118883 0.06006667 0.06970000 0.05630000 -0.01340000 0.934210151 0.004430051 FALSE TRUE
MSTRG.33597.7 ENSG00000160323 HEK293_OSMI2_6hA HEK293_TMG_6hB ADAMTS13 protein_coding   3.647197 5.292169 1.789093 1.022608 0.1878695 -1.559313 0.3037333 0.3727998 0.25916698 0.2037280 0.14560490 -0.5080886 0.09561250 0.05976667 0.16566667 0.10590000 0.898434175 0.004430051 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160323 E001 0.1779838 0.0345722319 0.110685497   9 133414358 133414644 287 + 0.215 0.000 -11.237
ENSG00000160323 E002 17.8414524 0.0070259197 0.033797121 0.13832296 9 133418140 133418501 362 + 1.333 1.140 -0.679
ENSG00000160323 E003 10.0535959 0.0059860369 0.424945685 0.64723345 9 133418502 133418547 46 + 1.026 0.936 -0.334
ENSG00000160323 E004 11.1182900 0.1091153133 0.161957951 0.37966657 9 133418548 133418631 84 + 1.169 0.935 -0.854
ENSG00000160323 E005 9.8168857 0.1306033987 0.092582959 0.26855320 9 133418632 133418662 31 + 1.169 0.865 -1.122
ENSG00000160323 E006 11.9436076 0.0026997821 0.014386079 0.07583130 9 133421769 133421844 76 + 1.214 0.960 -0.922
ENSG00000160323 E007 11.6459746 0.0028829793 0.004649032 0.03273227 9 133421845 133421921 77 + 1.231 0.936 -1.070
ENSG00000160323 E008 7.3168065 0.0043077349 0.001018608 0.01005248 9 133421922 133421956 35 + 1.120 0.718 -1.528
ENSG00000160323 E009 6.2746130 0.0059256870 0.001727355 0.01521418 9 133421957 133421978 22 + 1.075 0.675 -1.548
ENSG00000160323 E010 12.0291410 0.0197669571 0.250771464 0.48880072 9 133422000 133422323 324 + 1.141 0.995 -0.531
ENSG00000160323 E011 1.9502033 0.0110217055 0.768833818 0.87793534 9 133422324 133422324 1 + 0.358 0.419 0.342
ENSG00000160323 E012 3.9071838 0.0129907082 0.930265563 0.96710335 9 133422325 133422366 42 + 0.623 0.612 -0.049
ENSG00000160323 E013 4.0324425 0.0387531664 0.629641976 0.79027153 9 133422367 133422382 16 + 0.550 0.646 0.426
ENSG00000160323 E014 8.8703477 0.0220336300 0.555110074 0.73986294 9 133422383 133422523 141 + 0.829 0.929 0.384
ENSG00000160323 E015 5.1630651 0.0082456705 0.110480670 0.29975809 9 133422524 133422548 25 + 0.466 0.757 1.295
ENSG00000160323 E016 11.9798252 0.0194605221 0.937242674 0.97081648 9 133423101 133423167 67 + 1.025 1.026 0.003
ENSG00000160323 E017 16.4780100 0.0021714808 0.190892280 0.41802040 9 133424321 133424478 158 + 1.247 1.125 -0.432
ENSG00000160323 E018 15.9740863 0.0026877370 0.039598175 0.15371932 9 133425529 133425612 84 + 1.292 1.098 -0.689
ENSG00000160323 E019 17.2749177 0.0024112145 0.623496157 0.78623559 9 133425938 133426062 125 + 1.214 1.170 -0.157
ENSG00000160323 E020 13.3891984 0.0031732098 0.440412869 0.65900887 9 133426199 133426345 147 + 0.999 1.092 0.342
ENSG00000160323 E021 6.3952487 0.0045239015 0.028849922 0.12392827 9 133428634 133428771 138 + 0.466 0.846 1.644
ENSG00000160323 E022 11.2515826 0.0360924115 0.982054358 0.99277612 9 133429700 133429850 151 + 1.002 0.987 -0.053
ENSG00000160323 E023 7.3930033 0.0047075602 0.980492692 0.99200021 9 133429851 133429888 38 + 0.831 0.836 0.019
ENSG00000160323 E024 6.4744419 0.0052731057 0.099025937 0.28007837 9 133429889 133429924 36 + 0.552 0.826 1.152
ENSG00000160323 E025 5.3906224 0.0050510763 0.228229868 0.46317911 9 133429925 133429938 14 + 0.552 0.757 0.879
ENSG00000160323 E026 5.3725063 0.0073772348 0.105358074 0.29129041 9 133429939 133429943 5 + 0.466 0.758 1.297
ENSG00000160323 E027 9.9914945 0.0055213325 0.968544894 0.98611526 9 133429944 133430031 88 + 0.939 0.946 0.025
ENSG00000160323 E028 11.7333541 0.0040336278 0.706273327 0.83952175 9 133430032 133430101 70 + 0.970 1.019 0.181
ENSG00000160323 E029 1.5650459 0.0157443297 0.471287956 0.68109426 9 133430102 133430181 80 + 0.215 0.362 1.023
ENSG00000160323 E030 14.6792369 0.0023497171 0.489645181 0.69374654 9 133432588 133432692 105 + 1.160 1.092 -0.244
ENSG00000160323 E031 13.6824888 0.0452514185 0.436770644 0.65627086 9 133433378 133433529 152 + 1.139 1.063 -0.277
ENSG00000160323 E032 5.6358873 0.1409093654 0.156943029 0.37218391 9 133433641 133433653 13 + 0.905 0.690 -0.851
ENSG00000160323 E033 6.1424842 0.0270245580 0.116424503 0.30985047 9 133433654 133433704 51 + 0.938 0.719 -0.859
ENSG00000160323 E034 16.2202591 0.0144869368 0.587607714 0.76205952 9 133436829 133436955 127 + 1.195 1.132 -0.223
ENSG00000160323 E035 19.6874174 0.0020295139 0.930804826 0.96740516 9 133437749 133437897 149 + 1.231 1.224 -0.024
ENSG00000160323 E036 9.5539036 0.0034708805 0.548826996 0.73553022 9 133438246 133438366 121 + 0.999 0.928 -0.264
ENSG00000160323 E037 18.4805863 0.0044176980 0.327123024 0.56622569 9 133439366 133439446 81 + 1.120 1.219 0.355
ENSG00000160323 E038 27.4440365 0.0018180772 0.342432206 0.58016526 9 133440344 133440525 182 + 1.292 1.373 0.282
ENSG00000160323 E039 12.8547720 0.0028474822 0.527739455 0.72042471 9 133442399 133442518 120 + 0.999 1.074 0.277
ENSG00000160323 E040 3.3721372 0.0073330911 0.900230164 0.95198293 9 133442519 133442534 16 + 0.552 0.575 0.107
ENSG00000160323 E041 10.6072253 0.0032560217 0.302306522 0.54288995 9 133442614 133442743 130 + 0.870 1.004 0.504
ENSG00000160323 E042 7.1427209 0.0049880894 0.764472263 0.87527174 9 133443376 133443561 186 + 0.787 0.835 0.188
ENSG00000160323 E043 30.2790498 0.0021819450 0.887205584 0.94519742 9 133444863 133445052 190 + 1.404 1.394 -0.036
ENSG00000160323 E044 22.9117010 0.0218819159 0.338472778 0.57662677 9 133445699 133445819 121 + 1.181 1.302 0.427
ENSG00000160323 E045 23.8229942 0.0021092462 0.362127543 0.59746418 9 133448599 133448728 130 + 1.231 1.318 0.307
ENSG00000160323 E046 28.1345224 0.0014031713 0.047027910 0.17261127 9 133449783 133449965 183 + 1.231 1.404 0.605
ENSG00000160323 E047 27.9989749 0.1907094068 0.185392780 0.41106066 9 133454415 133454619 205 + 1.163 1.409 0.864
ENSG00000160323 E048 25.1577174 0.0258871488 0.071078642 0.22689878 9 133455285 133455435 151 + 1.160 1.363 0.714
ENSG00000160323 E049 15.7573551 0.0332387526 0.079206159 0.24322859 9 133455436 133455501 66 + 0.940 1.172 0.847
ENSG00000160323 E050 18.1344533 0.0440612950 0.090387111 0.26446680 9 133455502 133455603 102 + 1.000 1.226 0.816
ENSG00000160323 E051 5.7552202 0.0052563289 0.434323266 0.65448958 9 133455604 133455647 44 + 0.831 0.718 -0.449
ENSG00000160323 E052 15.8783722 0.0026356900 0.091274093 0.26603347 9 133455648 133455799 152 + 1.263 1.103 -0.567
ENSG00000160323 E053 34.3630132 0.0012542520 0.258395005 0.49719476 9 133456069 133456215 147 + 1.381 1.469 0.302
ENSG00000160323 E054 32.3493769 0.0011555719 0.094530872 0.27213040 9 133456543 133456719 177 + 1.319 1.454 0.467
ENSG00000160323 E055 28.1705208 0.0016034404 0.743552773 0.86269282 9 133457910 133458094 185 + 1.345 1.376 0.105
ENSG00000160323 E056 49.4335823 0.0008338379 0.783554015 0.88670270 9 133458974 133459450 477 + 1.617 1.604 -0.044