ENSG00000160285

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457828 ENSG00000160285 HEK293_OSMI2_6hA HEK293_TMG_6hB LSS protein_coding protein_coding 46.88716 73.21 29.64747 4.889321 0.4391114 -1.303842 25.681202 43.506059 12.531228 6.8621996 0.8918900 -1.79486931 0.51157500 0.59286667 0.42200000 -0.17086667 4.423254e-01 2.688393e-12 FALSE TRUE
ENST00000474319 ENSG00000160285 HEK293_OSMI2_6hA HEK293_TMG_6hB LSS protein_coding retained_intron 46.88716 73.21 29.64747 4.889321 0.4391114 -1.303842 2.438921 4.945036 0.000000 1.0514189 0.0000000 -8.95275163 0.04102083 0.06780000 0.00000000 -0.06780000 2.688393e-12 2.688393e-12 FALSE TRUE
ENST00000522411 ENSG00000160285 HEK293_OSMI2_6hA HEK293_TMG_6hB LSS protein_coding protein_coding 46.88716 73.21 29.64747 4.889321 0.4391114 -1.303842 4.085108 5.281998 4.850976 0.5266036 0.3154261 -0.12256663 0.11020833 0.07256667 0.16383333 0.09126667 1.758454e-03 2.688393e-12 FALSE TRUE
MSTRG.21506.6 ENSG00000160285 HEK293_OSMI2_6hA HEK293_TMG_6hB LSS protein_coding   46.88716 73.21 29.64747 4.889321 0.4391114 -1.303842 2.862337 4.786925 2.394222 1.6797895 0.2041920 -0.99653979 0.06509583 0.06586667 0.08086667 0.01500000 8.350543e-01 2.688393e-12 TRUE TRUE
MSTRG.21506.8 ENSG00000160285 HEK293_OSMI2_6hA HEK293_TMG_6hB LSS protein_coding   46.88716 73.21 29.64747 4.889321 0.4391114 -1.303842 4.143197 4.926294 4.754786 1.7433176 0.4615950 -0.05101689 0.10207500 0.06710000 0.16036667 0.09326667 2.166078e-01 2.688393e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160285 E001 0.3040503 0.0244411696 0.01994129   21 46188108 46188140 33 - 0.344 0.000 -13.964
ENSG00000160285 E002 0.4756169 0.0274255846 0.68242779   21 46188141 46188445 305 - 0.000 0.181 10.902
ENSG00000160285 E003 1.0237200 0.0160642112 0.90633306   21 46188446 46188473 28 - 0.205 0.270 0.516
ENSG00000160285 E004 23.7552982 0.0022561314 0.48523340 0.69071593 21 46188474 46188821 348 - 1.223 1.339 0.410
ENSG00000160285 E005 5.2015778 0.0220800931 0.58355802 0.75931175 21 46188822 46189123 302 - 0.765 0.724 -0.166
ENSG00000160285 E006 1.8093042 0.0240558314 0.66845641 0.81518407 21 46189124 46189124 1 - 0.449 0.405 -0.232
ENSG00000160285 E007 1317.9726285 1.4571505646 0.39608452 0.62522076 21 46189125 46190207 1083 - 2.822 3.082 0.864
ENSG00000160285 E008 861.4689939 1.3274450872 0.41819316 0.64227992 21 46190208 46190782 575 - 2.671 2.892 0.736
ENSG00000160285 E009 488.6613406 1.1002095590 0.37369555 0.60710691 21 46190783 46191065 283 - 2.414 2.648 0.778
ENSG00000160285 E010 143.8697487 0.4295429191 0.27943861 0.51952685 21 46191066 46191075 10 - 1.923 2.113 0.638
ENSG00000160285 E011 460.0359127 1.1160421264 0.42560675 0.64772032 21 46191076 46191235 160 - 2.432 2.614 0.609
ENSG00000160285 E012 342.0313324 0.9928365251 0.40221604 0.63017020 21 46191881 46191959 79 - 2.299 2.487 0.626
ENSG00000160285 E013 200.7758516 0.1920636005 0.96019599 0.98195112 21 46191960 46192680 721 - 2.235 2.219 -0.054
ENSG00000160285 E014 86.0619379 0.1001510812 0.02079614 0.09865532 21 46192681 46193021 341 - 2.030 1.795 -0.791
ENSG00000160285 E015 37.5464946 0.3616531569 0.78166090 0.88562126 21 46193022 46193148 127 - 1.645 1.458 -0.638
ENSG00000160285 E016 26.2564723 0.2365714529 0.39037326 0.62072686 21 46193149 46193265 117 - 1.565 1.276 -0.998
ENSG00000160285 E017 1.1015031 0.0143415510 0.73666649   21 46193266 46193291 26 - 0.205 0.308 0.773
ENSG00000160285 E018 5.8654673 0.1843062709 0.54880315 0.73551567 21 46193292 46193412 121 - 0.838 0.752 -0.339
ENSG00000160285 E019 18.2995280 0.3145303864 0.57278966 0.75224076 21 46193413 46193507 95 - 1.318 1.174 -0.510
ENSG00000160285 E020 29.6086481 0.3213447231 0.54304238 0.73124598 21 46193508 46193626 119 - 1.619 1.323 -1.018
ENSG00000160285 E021 42.1204990 0.4479307915 0.65383077 0.80598929 21 46193627 46193747 121 - 1.744 1.483 -0.889
ENSG00000160285 E022 19.3240291 0.2626521836 0.34783749 0.58528250 21 46193748 46193773 26 - 1.431 1.155 -0.964
ENSG00000160285 E023 54.3289269 0.4863569177 0.87120315 0.93659254 21 46193774 46194015 242 - 1.781 1.622 -0.540
ENSG00000160285 E024 122.8205327 0.6676757200 0.82086351 0.90852008 21 46194016 46194490 475 - 2.041 2.002 -0.131
ENSG00000160285 E025 437.0470579 1.1047013867 0.43855620 0.65768140 21 46194491 46194661 171 - 2.420 2.590 0.568
ENSG00000160285 E026 290.1074496 0.0124434078 0.07863706 0.24204559 21 46195676 46195756 81 - 2.266 2.411 0.484
ENSG00000160285 E027 248.2894122 0.0226685303 0.88836697 0.94581006 21 46196202 46196267 66 - 2.235 2.334 0.331
ENSG00000160285 E028 6.5640747 0.1871351367 0.24267223 0.47957510 21 46196268 46196371 104 - 0.921 0.763 -0.614
ENSG00000160285 E029 299.4666850 0.0404610187 0.36402353 0.59907305 21 46205836 46205941 106 - 2.391 2.396 0.015
ENSG00000160285 E030 285.4997560 0.0581718102 0.34842507 0.58587064 21 46206672 46206768 97 - 2.386 2.371 -0.050
ENSG00000160285 E031 363.4093876 0.0648689470 0.21905876 0.45232192 21 46207428 46207577 150 - 2.521 2.466 -0.182
ENSG00000160285 E032 242.5985534 0.0620149887 0.11833715 0.31313000 21 46208251 46208301 51 - 2.376 2.282 -0.316
ENSG00000160285 E033 274.9164857 0.0704785007 0.14598112 0.35634544 21 46209554 46209625 72 - 2.428 2.336 -0.307
ENSG00000160285 E034 265.7684644 0.0449886622 0.06622240 0.21655827 21 46210688 46210744 57 - 2.417 2.320 -0.324
ENSG00000160285 E035 205.8530988 0.0328753073 0.08771160 0.25947893 21 46213025 46213052 28 - 2.283 2.218 -0.216
ENSG00000160285 E036 290.0023311 0.0446768590 0.15749497 0.37295555 21 46213738 46213835 98 - 2.421 2.370 -0.170
ENSG00000160285 E037 280.0248256 0.0495149203 0.21154162 0.44361256 21 46215180 46215298 119 - 2.397 2.357 -0.135
ENSG00000160285 E038 251.8102990 0.0616707985 0.32865087 0.56763508 21 46215685 46215793 109 - 2.338 2.315 -0.078
ENSG00000160285 E039 309.4716173 0.0249737509 0.09390390 0.27095022 21 46216389 46216524 136 - 2.443 2.400 -0.146
ENSG00000160285 E040 244.1616082 0.0015249937 0.01229378 0.06761776 21 46219476 46219572 97 - 2.329 2.305 -0.080
ENSG00000160285 E041 251.6914181 0.9443548853 0.50259285 0.70258050 21 46221854 46221975 122 - 2.247 2.338 0.303
ENSG00000160285 E042 121.6511035 0.0180337454 0.98648329 0.99509691 21 46222630 46222662 33 - 1.988 2.015 0.090
ENSG00000160285 E043 201.0748161 0.0003177234 0.08001401 0.24488132 21 46222663 46222738 76 - 2.227 2.232 0.017
ENSG00000160285 E044 7.3634170 0.1761096398 0.04187303 0.15962923 21 46227319 46227551 233 - 1.077 0.756 -1.221
ENSG00000160285 E045 233.3119137 0.0345875357 0.18753684 0.41381678 21 46227552 46227690 139 - 2.310 2.281 -0.094
ENSG00000160285 E046 195.4523638 0.0720989940 0.51855804 0.71409327 21 46228434 46228599 166 - 2.203 2.213 0.036
ENSG00000160285 E047 23.0152064 0.0231103408 0.14235014 0.35094766 21 46228600 46228684 85 - 1.114 1.355 0.850
ENSG00000160285 E048 17.6777638 0.0037971069 0.08696472 0.25817314 21 46228685 46228731 47 - 1.003 1.247 0.879
ENSG00000160285 E049 73.7022535 0.0623864864 0.65327466 0.80561370 21 46228732 46228824 93 - 1.764 1.800 0.121