ENSG00000160221

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291577 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding protein_coding 68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 21.976430 27.733022 11.381650 6.0718134 1.6603443 -1.28414824 0.30199583 0.31270000 0.26980000 -0.04290000 0.82968375 3.412095e-20 FALSE TRUE
ENST00000348499 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding protein_coding 68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 9.214269 12.218307 2.782453 3.2816754 0.9041495 -2.13061965 0.11858750 0.13443333 0.06516667 -0.06926667 0.38959290 3.412095e-20 FALSE TRUE
ENST00000427803 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding protein_coding 68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 9.552859 13.921102 4.347422 2.7807399 0.5792330 -1.67676260 0.13505000 0.15886667 0.10423333 -0.05463333 0.37964962 3.412095e-20 FALSE TRUE
ENST00000488392 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding retained_intron 68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 3.338832 3.537466 3.627317 0.6994752 0.6527267 0.03608598 0.05632500 0.04776667 0.08523333 0.03746667 0.53619611 3.412095e-20 FALSE TRUE
ENST00000495007 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding retained_intron 68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 4.191941 4.479713 3.498844 0.5804695 0.4029000 -0.35562751 0.06667083 0.05330000 0.08256667 0.02926667 0.35709358 3.412095e-20 FALSE TRUE
MSTRG.21426.5 ENSG00000160221 HEK293_OSMI2_6hA HEK293_TMG_6hB GATD3 protein_coding   68.91966 87.24118 42.15032 15.7182 1.381062 -1.049289 9.950504 9.860572 9.048204 2.1547998 0.7485424 -0.12390869 0.15587500 0.11260000 0.21446667 0.10186667 0.01246401 3.412095e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160221 E001 0.4873834 0.5166979405 0.67582518   21 44133053 44133295 243 + 0.209 0.127 -0.870
ENSG00000160221 E002 0.9105353 0.0203432688 0.49599469   21 44133610 44133615 6 + 0.353 0.221 -0.924
ENSG00000160221 E003 0.9105353 0.0203432688 0.49599469   21 44133616 44133616 1 + 0.353 0.221 -0.924
ENSG00000160221 E004 2.9632951 0.0142722832 0.04770215 0.17429961 21 44133617 44133617 1 + 0.779 0.450 -1.462
ENSG00000160221 E005 10.6249363 0.0539213221 0.11683012 0.31055036 21 44133618 44133638 21 + 1.168 0.914 -0.930
ENSG00000160221 E006 13.5362782 0.0216111416 0.38150586 0.61348550 21 44133639 44133641 3 + 1.170 1.047 -0.440
ENSG00000160221 E007 37.9975737 0.0012643097 0.51700061 0.71300975 21 44133642 44133673 32 + 1.466 1.505 0.133
ENSG00000160221 E008 41.6711595 0.0012190877 0.47307888 0.68219833 21 44133674 44133679 6 + 1.502 1.544 0.143
ENSG00000160221 E009 47.9942052 0.0013463890 0.65006808 0.80360375 21 44133680 44133682 3 + 1.580 1.602 0.072
ENSG00000160221 E010 95.8659514 0.0004777104 0.69059072 0.82946007 21 44133683 44133778 96 + 1.886 1.898 0.038
ENSG00000160221 E011 60.0286135 0.0008488179 0.68961917 0.82878552 21 44133779 44133838 60 + 1.682 1.699 0.058
ENSG00000160221 E012 0.5421338 0.0213015638 0.09145241   21 44133839 44134101 263 + 0.354 0.067 -2.922
ENSG00000160221 E013 43.1667995 0.0010780765 0.17203413 0.39323971 21 44134102 44134154 53 + 1.485 1.570 0.291
ENSG00000160221 E014 19.2342556 0.0018663218 0.35151050 0.58863653 21 44136060 44136074 15 + 1.152 1.236 0.300
ENSG00000160221 E015 20.8378436 0.0019380281 0.18347309 0.40843602 21 44136075 44136106 32 + 1.152 1.273 0.427
ENSG00000160221 E016 10.6909243 0.0055757055 0.20498035 0.43588878 21 44136107 44136118 12 + 0.862 1.024 0.607
ENSG00000160221 E017 12.9006898 0.0024893795 0.09652730 0.27570089 21 44136119 44136150 32 + 0.898 1.094 0.725
ENSG00000160221 E018 9.9773938 0.0032010490 0.19586724 0.42440128 21 44136151 44136173 23 + 0.823 0.990 0.634
ENSG00000160221 E019 0.0000000       21 44136874 44136982 109 +      
ENSG00000160221 E020 0.0000000       21 44136983 44137027 45 +      
ENSG00000160221 E021 10.8550870 0.0357506554 0.46080096 0.67373101 21 44137177 44137296 120 + 1.069 0.980 -0.326
ENSG00000160221 E022 0.4458772 0.0217681645 0.60611277   21 44137297 44137575 279 + 0.212 0.124 -0.923
ENSG00000160221 E023 5.2687197 0.0080896693 0.25446320 0.49298071 21 44140250 44140342 93 + 0.862 0.696 -0.665
ENSG00000160221 E024 4.4682621 0.0196203526 0.19675928 0.42548090 21 44140343 44140604 262 + 0.460 0.697 1.079
ENSG00000160221 E025 10.4963928 0.0032868366 0.48879208 0.69318506 21 44140942 44141163 222 + 1.043 0.960 -0.309
ENSG00000160221 E026 8.8119148 0.0035888157 0.83303947 0.91547820 21 44141164 44141417 254 + 0.931 0.901 -0.116
ENSG00000160221 E027 3.6275672 0.0150434081 0.00159247 0.01427038 21 44143205 44143361 157 + 0.932 0.450 -2.056
ENSG00000160221 E028 7.3974569 0.0043357729 0.25341889 0.49166340 21 44144821 44144916 96 + 0.962 0.810 -0.581
ENSG00000160221 E029 74.6226021 0.0022102225 0.44181948 0.65997683 21 44144917 44145570 654 + 1.822 1.780 -0.143
ENSG00000160221 E030 77.1086672 0.0096652614 0.40614171 0.63316751 21 44145571 44145723 153 + 1.844 1.789 -0.186
ENSG00000160221 E031 0.7087110 0.0193874923 0.37524981   21 44162582 44162823 242 + 0.001 0.221 8.507
ENSG00000160221 E032 0.0000000       21 44193624 44194535 912 +      
ENSG00000160221 E033 0.0000000       21 44197171 44197892 722 +      
ENSG00000160221 E034 0.0000000       21 44202050 44203064 1015 +      
ENSG00000160221 E035 0.5365243 0.0256087788 0.61019381   21 44207913 44208219 307 + 0.212 0.125 -0.919
ENSG00000160221 E036 0.3503582 0.0373148157 0.34261555   21 44208469 44210114 1646 + 0.212 0.067 -1.923