ENSG00000160214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000497547 ENSG00000160214 HEK293_OSMI2_6hA HEK293_TMG_6hB RRP1 protein_coding protein_coding 127.0685 163.0657 84.41764 26.69294 2.574296 -0.9497541 32.176578 43.37599 12.51923 9.367933 1.1187659 -1.7919312 0.22878750 0.26040000 0.14883333 -0.11156667 0.03580977 0.03580977 FALSE TRUE
MSTRG.21416.4 ENSG00000160214 HEK293_OSMI2_6hA HEK293_TMG_6hB RRP1 protein_coding   127.0685 163.0657 84.41764 26.69294 2.574296 -0.9497541 9.636104 14.30313 5.95761 2.618253 0.3437565 -1.2621142 0.07566667 0.08763333 0.07066667 -0.01696667 0.66223932 0.03580977 FALSE TRUE
MSTRG.21416.9 ENSG00000160214 HEK293_OSMI2_6hA HEK293_TMG_6hB RRP1 protein_coding   127.0685 163.0657 84.41764 26.69294 2.574296 -0.9497541 73.068930 90.36026 52.43326 15.744776 1.1585339 -0.7850908 0.58915000 0.55160000 0.62146667 0.06986667 0.15710958 0.03580977 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160214 E001 1.9390570 1.057192e-02 3.866252e-01 6.177935e-01 21 43776299 43776336 38 + 0.311 0.475 0.925
ENSG00000160214 E002 0.1723744 4.695516e-02 1.000000e+00   21 43789513 43789518 6 + 0.000 0.079 7.519
ENSG00000160214 E003 0.8100271 1.712730e-02 5.490435e-01   21 43789519 43789531 13 + 0.311 0.203 -0.810
ENSG00000160214 E004 1.3334997 1.449529e-02 7.382055e-01   21 43789532 43789541 10 + 0.311 0.378 0.406
ENSG00000160214 E005 1.3334997 1.449529e-02 7.382055e-01   21 43789542 43789542 1 + 0.311 0.378 0.406
ENSG00000160214 E006 23.1628001 1.655628e-02 1.605724e-01 3.776384e-01 21 43789543 43789558 16 + 1.234 1.379 0.506
ENSG00000160214 E007 57.3518504 9.086003e-04 1.374001e-01 3.435317e-01 21 43789559 43789576 18 + 1.658 1.741 0.281
ENSG00000160214 E008 607.6209800 1.680897e-03 5.153650e-01 7.118884e-01 21 43789577 43789695 119 + 2.747 2.731 -0.053
ENSG00000160214 E009 669.5694514 8.338578e-04 9.769937e-01 9.902595e-01 21 43789696 43789762 67 + 2.777 2.778 0.001
ENSG00000160214 E010 2.7747597 1.299908e-01 8.484205e-01 9.240401e-01 21 43790493 43791015 523 + 0.562 0.511 -0.236
ENSG00000160214 E011 2.8462684 8.251392e-03 9.633249e-01 9.836106e-01 21 43791016 43791056 41 + 0.558 0.554 -0.020
ENSG00000160214 E012 771.8206925 9.693741e-05 8.053926e-01 8.993565e-01 21 43791350 43791432 83 + 2.835 2.842 0.022
ENSG00000160214 E013 659.4522420 2.745473e-04 2.099058e-02 9.931693e-02 21 43792672 43792729 58 + 2.797 2.760 -0.122
ENSG00000160214 E014 40.3870120 1.425644e-01 2.164103e-02 1.014189e-01 21 43792730 43792930 201 + 1.821 1.414 -1.386
ENSG00000160214 E015 66.0723441 8.321317e-02 7.205838e-03 4.561003e-02 21 43792931 43793318 388 + 2.027 1.627 -1.349
ENSG00000160214 E016 839.4777093 8.863965e-05 4.012355e-03 2.923292e-02 21 43793319 43793404 86 + 2.902 2.866 -0.119
ENSG00000160214 E017 3.2864162 8.780157e-03 4.756209e-01 6.839352e-01 21 43793405 43793419 15 + 0.669 0.555 -0.501
ENSG00000160214 E018 749.2177605 1.136190e-04 1.260697e-03 1.186518e-02 21 43795189 43795250 62 + 2.859 2.816 -0.144
ENSG00000160214 E019 5.3458281 2.001480e-01 5.488400e-01 7.355312e-01 21 43797361 43797421 61 + 0.884 0.712 -0.681
ENSG00000160214 E020 397.3844722 2.563418e-04 3.318662e-03 2.531598e-02 21 43797422 43797425 4 + 2.594 2.538 -0.189
ENSG00000160214 E021 1038.2095930 7.603911e-05 2.170116e-02 1.015889e-01 21 43797426 43797551 126 + 2.987 2.962 -0.082
ENSG00000160214 E022 836.0542083 8.832508e-05 3.221696e-02 1.338646e-01 21 43797631 43797695 65 + 2.893 2.867 -0.086
ENSG00000160214 E023 1125.9482471 2.134709e-04 1.183730e-02 6.578674e-02 21 43797907 43798049 143 + 3.024 2.994 -0.100
ENSG00000160214 E024 683.2000062 6.607350e-04 8.659687e-01 9.337071e-01 21 43798050 43798100 51 + 2.781 2.787 0.019
ENSG00000160214 E025 845.2589757 3.910090e-04 7.864340e-01 8.883681e-01 21 43799570 43799649 80 + 2.873 2.880 0.022
ENSG00000160214 E026 882.6649839 6.306004e-04 4.304436e-01 6.514704e-01 21 43800517 43800614 98 + 2.884 2.901 0.055
ENSG00000160214 E027 543.2099813 1.860878e-03 4.863144e-01 6.914763e-01 21 43800862 43800881 20 + 2.669 2.691 0.076
ENSG00000160214 E028 38.7671722 5.149925e-02 2.906558e-01 5.313244e-01 21 43800882 43800922 41 + 1.649 1.507 -0.485
ENSG00000160214 E029 30.4249143 1.235450e-01 2.303512e-01 4.655351e-01 21 43801657 43801722 66 + 1.576 1.390 -0.639
ENSG00000160214 E030 878.2499702 4.492289e-04 1.445896e-04 2.034654e-03 21 43802274 43802387 114 + 2.846 2.911 0.217
ENSG00000160214 E031 1966.7117007 3.844248e-04 7.702082e-17 1.491437e-14 21 43803512 43805293 1782 + 3.168 3.270 0.338
ENSG00000160214 E032 6.1973366 1.538337e-01 7.539993e-01 8.691248e-01 21 43820526 43820679 154 + 0.760 0.825 0.258