ENSG00000160201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291552 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding protein_coding 16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 4.278380 4.702629 3.9712048 0.9849933 1.9857789 -0.2433270 0.25376667 0.3511333 0.22013333 -0.13100000 0.85728415 0.01495782 FALSE TRUE
ENST00000380276 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding protein_coding 16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 1.210534 0.000000 0.8295619 0.0000000 0.8295619 6.3915648 0.07239583 0.0000000 0.04913333 0.04913333 0.91992485 0.01495782 FALSE TRUE
ENST00000468039 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding retained_intron 16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 1.264669 0.301663 2.5359578 0.3016630 0.2809522 3.0301496 0.07507083 0.0215000 0.14373333 0.12223333 0.16192039 0.01495782   FALSE
ENST00000478282 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding retained_intron 16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 2.024742 1.413936 2.6080157 0.2222550 0.1627981 0.8785894 0.12818750 0.1058667 0.14740000 0.04153333 0.56741024 0.01495782 TRUE FALSE
ENST00000496462 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding retained_intron 16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 2.591351 1.550416 4.3828629 0.2461883 0.3376108 1.4932304 0.15822083 0.1155333 0.24850000 0.13296667 0.01495782 0.01495782 FALSE FALSE
MSTRG.21401.11 ENSG00000160201 HEK293_OSMI2_6hA HEK293_TMG_6hB U2AF1 protein_coding   16.46787 13.33065 17.66004 0.4249815 0.4613347 0.4054759 3.684576 4.669376 1.3897385 1.6614842 0.4355212 -1.7411587 0.22693333 0.3531000 0.08000000 -0.27310000 0.15558054 0.01495782 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160201 E001 0.1779838 0.032141106 5.160871e-01   21 43092048 43092192 145 - 0.116 0.000 -10.025
ENSG00000160201 E002 0.1779838 0.032141106 5.160871e-01   21 43092193 43092697 505 - 0.116 0.000 -12.253
ENSG00000160201 E003 0.0000000       21 43092698 43092955 258 -      
ENSG00000160201 E004 0.1308682 0.031603593 4.616639e-01   21 43092956 43093189 234 - 0.000 0.127 11.689
ENSG00000160201 E005 0.1723744 0.030796820 4.619300e-01   21 43093190 43093249 60 - 0.000 0.127 11.693
ENSG00000160201 E006 0.0000000       21 43093250 43093893 644 -      
ENSG00000160201 E007 4.5707431 0.005838913 3.168810e-01 0.556867531 21 43093894 43094470 577 - 0.794 0.675 -0.483
ENSG00000160201 E008 2.4436441 0.011582905 8.608525e-01 0.930777823 21 43094471 43094563 93 - 0.539 0.528 -0.049
ENSG00000160201 E009 3.3199278 0.009917116 5.934890e-01 0.765994947 21 43094655 43094788 134 - 0.575 0.676 0.437
ENSG00000160201 E010 14.5133771 0.016739794 4.465924e-01 0.663157893 21 43094789 43095437 649 - 1.206 1.156 -0.177
ENSG00000160201 E011 8.4386000 0.005027162 8.628567e-01 0.931934243 21 43095438 43095533 96 - 0.953 0.992 0.146
ENSG00000160201 E012 4.4301473 0.006365647 7.982540e-01 0.895304397 21 43095534 43095536 3 - 0.748 0.733 -0.063
ENSG00000160201 E013 3.6452305 0.007756559 4.663033e-01 0.677515584 21 43095537 43095693 157 - 0.609 0.733 0.524
ENSG00000160201 E014 3.9963965 0.007532668 9.372244e-01 0.970803450 21 43095694 43095701 8 - 0.698 0.705 0.031
ENSG00000160201 E015 5.4188780 0.015902061 2.666934e-01 0.506205144 21 43095702 43095743 42 - 0.723 0.892 0.665
ENSG00000160201 E016 0.3393995 0.027442404 2.164834e-01   21 43095744 43096390 647 - 0.208 0.000 -13.147
ENSG00000160201 E017 35.7515364 0.004187860 4.818783e-04 0.005511079 21 43097622 43100452 2831 - 1.641 1.469 -0.586
ENSG00000160201 E018 7.4350506 0.004316181 1.803645e-01 0.404458461 21 43100453 43100519 67 - 0.834 1.007 0.653
ENSG00000160201 E019 0.2027342 0.044795022 4.597744e-01   21 43100520 43100576 57 - 0.000 0.127 11.669
ENSG00000160201 E020 0.0000000       21 43100577 43100614 38 -      
ENSG00000160201 E021 0.0000000       21 43100615 43101365 751 -      
ENSG00000160201 E022 1.6195066 0.026423876 9.364400e-01 0.970440804 21 43101366 43101432 67 - 0.404 0.430 0.141
ENSG00000160201 E023 7.1719673 0.008345877 9.073681e-05 0.001377666 21 43101433 43104314 2882 - 1.081 0.607 -1.858
ENSG00000160201 E024 17.8910502 0.033882621 8.224425e-03 0.050358712 21 43104315 43104402 88 - 1.104 1.405 1.060
ENSG00000160201 E025 4.8673464 0.008171694 9.083050e-02 0.265253677 21 43104403 43105252 850 - 0.854 0.643 -0.854
ENSG00000160201 E026 29.7961480 0.025039726 1.670672e-02 0.084388762 21 43107451 43107649 199 - 1.371 1.584 0.735