ENSG00000160094

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373428 ENSG00000160094 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF362 protein_coding protein_coding 15.57098 25.31909 8.49398 3.576433 0.3001659 -1.574585 5.8435977 9.263347 5.0837328 1.3645511 0.1975164 -0.8643669 0.36343750 0.36600000 0.6010667 0.23506667 0.005187897 0.005187897 FALSE TRUE
ENST00000477934 ENSG00000160094 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF362 protein_coding retained_intron 15.57098 25.31909 8.49398 3.576433 0.3001659 -1.574585 0.8246674 1.324318 0.8529612 0.4870878 0.0942807 -0.6287352 0.05451667 0.05096667 0.1007333 0.04976667 0.378082966 0.005187897 FALSE FALSE
ENST00000539719 ENSG00000160094 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF362 protein_coding protein_coding 15.57098 25.31909 8.49398 3.576433 0.3001659 -1.574585 2.1593915 3.051393 0.8372370 0.4533880 0.2028134 -1.8533509 0.14805000 0.12263333 0.0975000 -0.02513333 0.831687446 0.005187897 FALSE TRUE
MSTRG.794.2 ENSG00000160094 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF362 protein_coding   15.57098 25.31909 8.49398 3.576433 0.3001659 -1.574585 6.7082551 11.399450 1.7200490 1.8548804 0.2930328 -2.7213444 0.43282917 0.45120000 0.2007000 -0.25050000 0.008483752 0.005187897 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160094 E001 3.534293 0.0075713797 6.975784e-01 0.833957676 1 33256492 33256523 32 + 0.546 0.616 0.316
ENSG00000160094 E002 4.301818 0.0131112317 1.801808e-01 0.404233294 1 33256524 33256544 21 + 0.460 0.708 1.122
ENSG00000160094 E003 20.578856 0.0017489366 7.720452e-05 0.001204693 1 33256545 33256618 74 + 0.863 1.312 1.631
ENSG00000160094 E004 22.663779 0.0015131482 7.926131e-02 0.243327590 1 33256619 33256654 36 + 1.153 1.319 0.586
ENSG00000160094 E005 11.234135 0.0030110953 3.569221e-01 0.593227132 1 33270487 33270574 88 + 1.091 0.989 -0.372
ENSG00000160094 E006 9.665125 0.0034422137 6.844405e-01 0.825588201 1 33270575 33270612 38 + 0.991 0.943 -0.181
ENSG00000160094 E007 2.774124 0.0302185939 1.388300e-02 0.073884445 1 33275214 33275248 35 + 0.001 0.565 10.786
ENSG00000160094 E008 41.992555 0.0008461858 9.820921e-01 0.992778525 1 33276100 33276163 64 + 1.544 1.547 0.010
ENSG00000160094 E009 75.988418 0.0006340211 2.103622e-01 0.442247880 1 33276348 33276594 247 + 1.746 1.811 0.219
ENSG00000160094 E010 115.602953 0.0003978366 5.719525e-01 0.751658659 1 33280124 33280349 226 + 1.959 1.983 0.081
ENSG00000160094 E011 116.612881 0.0004120922 8.683337e-01 0.935043216 1 33280350 33280457 108 + 1.974 1.982 0.027
ENSG00000160094 E012 201.467309 0.0017272328 7.302217e-02 0.230884514 1 33281587 33281811 225 + 2.261 2.200 -0.202
ENSG00000160094 E013 6.236709 0.0052116319 3.142371e-01 0.554473009 1 33281812 33281973 162 + 0.899 0.762 -0.533
ENSG00000160094 E014 140.746505 0.0031755343 7.235021e-02 0.229474062 1 33294937 33295015 79 + 2.120 2.042 -0.260
ENSG00000160094 E015 174.258229 0.0003773868 3.589980e-01 0.595029350 1 33295147 33295305 159 + 2.175 2.146 -0.095
ENSG00000160094 E016 839.251693 0.0012737302 3.834290e-01 0.615099640 1 33298930 33300719 1790 + 2.821 2.835 0.044