ENSG00000160007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404338 ENSG00000160007 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP35 protein_coding protein_coding 12.75357 15.13557 12.03692 2.851785 0.4673437 -0.3302315 3.140123 5.066766 3.01806208 1.5734402 0.37938466 -0.7455150 0.2418583 0.3166667 0.2527666667 -0.0639000 8.118547e-01 3.247245e-11 FALSE TRUE
ENST00000672722 ENSG00000160007 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP35 protein_coding protein_coding 12.75357 15.13557 12.03692 2.851785 0.4673437 -0.3302315 6.830999 6.077889 8.60743739 0.6701219 0.56398942 0.5013168 0.5452292 0.4179333 0.7138666667 0.2959333 9.546119e-04 3.247245e-11 FALSE TRUE
MSTRG.17378.2 ENSG00000160007 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP35 protein_coding   12.75357 15.13557 12.03692 2.851785 0.4673437 -0.3302315 2.034403 3.135021 0.01034087 1.0151989 0.01034087 -7.2725440 0.1516125 0.1935000 0.0008333333 -0.1926667 3.247245e-11 3.247245e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000160007 E001 6.4565274 0.0048584107 8.299614e-01 9.137519e-01 19 46860997 46861075 79 + 0.871 0.869 -0.007
ENSG00000160007 E002 24.8030820 0.0120562971 1.736831e-01 3.954441e-01 19 46861076 46861209 134 + 1.460 1.364 -0.332
ENSG00000160007 E003 30.1919902 0.0012095922 5.289285e-02 1.864734e-01 19 46918488 46918539 52 + 1.543 1.448 -0.326
ENSG00000160007 E004 65.1474440 0.0006654163 8.406655e-05 1.293670e-03 19 46918540 46918675 136 + 1.893 1.748 -0.488
ENSG00000160007 E005 1154.8359275 0.0002691361 3.814347e-47 1.044780e-43 19 46918676 46922303 3628 + 3.121 3.003 -0.390
ENSG00000160007 E006 74.9624586 0.0005431075 1.624744e-01 3.804518e-01 19 46922304 46922356 53 + 1.893 1.865 -0.096
ENSG00000160007 E007 75.1691827 0.0005823246 1.670771e-03 1.481690e-02 19 46937264 46937319 56 + 1.933 1.832 -0.338
ENSG00000160007 E008 91.2699999 0.0004953055 1.169042e-03 1.119300e-02 19 46937320 46937408 89 + 2.011 1.918 -0.310
ENSG00000160007 E009 90.4510810 0.0005518836 1.782794e-02 8.845632e-02 19 46987989 46988066 78 + 1.989 1.929 -0.202
ENSG00000160007 E010 0.6841482 0.2974605997 8.281826e-01   19 46988067 46989543 1477 + 0.236 0.202 -0.291
ENSG00000160007 E011 69.5241608 0.0006403916 1.177838e-02 6.554899e-02 19 46989544 46989583 40 + 1.887 1.808 -0.268
ENSG00000160007 E012 109.8812913 0.0004643805 4.331565e-01 6.535656e-01 19 46989584 46989675 92 + 2.040 2.041 0.005
ENSG00000160007 E013 2.5388326 0.4372744429 5.065094e-01 7.052939e-01 19 46997497 46997750 254 + 0.394 0.631 1.146
ENSG00000160007 E014 0.7491197 0.0359076985 2.835616e-01   19 46999085 46999097 13 + 0.133 0.335 1.703
ENSG00000160007 E015 1.4166997 0.2795968199 6.521527e-01 8.048305e-01 19 46999098 46999144 47 + 0.315 0.437 0.703
ENSG00000160007 E016 2.8989209 0.0656301220 2.291339e-01 4.641136e-01 19 46999145 46999303 159 + 0.445 0.679 1.079
ENSG00000160007 E017 119.7865384 0.0003757300 7.608434e-01 8.730685e-01 19 46999304 46999409 106 + 2.058 2.097 0.131
ENSG00000160007 E018 2.4524759 0.2605714438 9.907992e-02 2.801447e-01 19 46999410 46999815 406 + 0.233 0.670 2.375
ENSG00000160007 E019 497.0500041 0.0008794383 2.931442e-03 2.298687e-02 19 47000331 47001714 1384 + 2.642 2.731 0.299
ENSG00000160007 E020 190.4046091 0.0007729945 2.773779e-10 1.786994e-08 19 47001715 47002137 423 + 2.147 2.358 0.704
ENSG00000160007 E021 965.5178722 0.0017061460 6.473631e-22 2.379592e-19 19 47002138 47005077 2940 + 2.854 3.063 0.697