ENSG00000159840

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322764 ENSG00000159840 HEK293_OSMI2_6hA HEK293_TMG_6hB ZYX protein_coding protein_coding 65.90093 86.17551 24.36736 20.77956 1.201217 -1.821904 40.123990 52.306168 18.210293 14.642237 0.5388341 -1.521711 0.61025000 0.5892333 0.7512667 0.1620333 3.293463e-01 8.283326e-05 FALSE TRUE
ENST00000354434 ENSG00000159840 HEK293_OSMI2_6hA HEK293_TMG_6hB ZYX protein_coding protein_coding 65.90093 86.17551 24.36736 20.77956 1.201217 -1.821904 7.138013 7.786421 1.747844 1.679734 0.8044017 -2.149005 0.08796667 0.0928000 0.0694000 -0.0234000 8.185918e-01 8.283326e-05 FALSE TRUE
MSTRG.30855.2 ENSG00000159840 HEK293_OSMI2_6hA HEK293_TMG_6hB ZYX protein_coding   65.90093 86.17551 24.36736 20.77956 1.201217 -1.821904 15.400683 22.793399 2.154193 5.664626 0.3690785 -3.397348 0.22845417 0.2655667 0.0886000 -0.1769667 8.283326e-05 8.283326e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159840 E001 4.449557 0.2058406679 4.661012e-01 6.773232e-01 7 143379609 143380987 1379 + 0.494 0.668 0.783
ENSG00000159840 E002 4.572372 0.0152722375 3.823381e-01 6.141153e-01 7 143381225 143381294 70 + 0.779 0.635 -0.593
ENSG00000159840 E003 27.824659 0.0085492175 3.314028e-05 5.877175e-04 7 143381295 143381344 50 + 0.911 1.399 1.752
ENSG00000159840 E004 30.610362 0.0042016991 1.678615e-06 4.476561e-05 7 143381345 143381359 15 + 0.911 1.441 1.894
ENSG00000159840 E005 34.741091 0.0041156396 2.804934e-06 7.011220e-05 7 143381360 143381360 1 + 1.013 1.490 1.685
ENSG00000159840 E006 86.374587 0.0005584333 4.742590e-13 5.182759e-11 7 143381361 143381409 49 + 1.416 1.874 1.561
ENSG00000159840 E007 5.543662 0.0345690183 7.164296e-02 2.281217e-01 7 143381410 143381556 147 + 0.386 0.768 1.762
ENSG00000159840 E008 40.879382 0.0026736966 9.267579e-05 1.403463e-03 7 143381557 143381559 3 + 1.205 1.549 1.194
ENSG00000159840 E009 87.757920 0.0025253724 1.327382e-06 3.634049e-05 7 143381560 143381574 15 + 1.566 1.867 1.022
ENSG00000159840 E010 263.431423 0.0002780446 4.912132e-02 1.774954e-01 7 143381575 143381779 205 + 2.257 2.310 0.178
ENSG00000159840 E011 2.009893 0.4191852089 1.010643e-01 2.837244e-01 7 143381907 143382027 121 + 0.722 0.282 -2.223
ENSG00000159840 E012 2.182268 0.4913519384 1.353683e-01 3.403406e-01 7 143382028 143382091 64 + 0.721 0.316 -1.994
ENSG00000159840 E013 325.494013 0.0034378094 8.234986e-02 2.493830e-01 7 143382248 143382447 200 + 2.449 2.374 -0.252
ENSG00000159840 E014 8.403194 0.2151944393 1.259782e-01 3.254635e-01 7 143382448 143382592 145 + 1.138 0.770 -1.383
ENSG00000159840 E015 298.242791 0.0046884196 1.066476e-02 6.096205e-02 7 143382593 143382685 93 + 2.442 2.326 -0.385
ENSG00000159840 E016 281.773467 0.0082294073 3.306631e-02 1.362602e-01 7 143382801 143382849 49 + 2.420 2.301 -0.398
ENSG00000159840 E017 483.069658 0.0052296738 4.829695e-02 1.757018e-01 7 143382850 143382999 150 + 2.629 2.541 -0.294
ENSG00000159840 E018 806.479752 0.0001391745 8.530656e-04 8.715043e-03 7 143383000 143383322 323 + 2.832 2.774 -0.194
ENSG00000159840 E019 4.000458 0.4089691510 5.701365e-02 1.960950e-01 7 143384090 143384245 156 + 1.014 0.427 -2.480
ENSG00000159840 E020 1.962590 0.1347070692 3.226404e-01 5.620303e-01 7 143387762 143387787 26 + 0.584 0.338 -1.268
ENSG00000159840 E021 6.730238 0.3535110629 6.550359e-01 8.067308e-01 7 143387889 143388218 330 + 0.877 0.757 -0.471
ENSG00000159840 E022 454.173304 0.0012141888 6.680968e-01 8.149699e-01 7 143388219 143388339 121 + 2.533 2.536 0.011
ENSG00000159840 E023 480.629806 0.0008737438 2.706082e-01 5.105543e-01 7 143388489 143388658 170 + 2.543 2.564 0.071
ENSG00000159840 E024 608.376104 0.0001752932 7.278412e-01 8.529426e-01 7 143388767 143388945 179 + 2.663 2.664 0.003
ENSG00000159840 E025 605.169877 0.0183680726 6.607018e-01 8.103828e-01 7 143389857 143389977 121 + 2.649 2.656 0.022
ENSG00000159840 E026 920.979102 0.0199667064 3.064081e-01 5.470554e-01 7 143390578 143391111 534 + 2.801 2.843 0.142