ENSG00000159322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311669 ENSG00000159322 HEK293_OSMI2_6hA HEK293_TMG_6hB ADPGK protein_coding protein_coding 47.61049 35.34438 50.87754 7.95689 1.598626 0.5254236 22.648647 15.422067 24.441016 4.6667726 0.9230012 0.66396307 0.47295000 0.42310000 0.481000000 0.057900000 0.74269818 0.03867999 FALSE TRUE
ENST00000456471 ENSG00000159322 HEK293_OSMI2_6hA HEK293_TMG_6hB ADPGK protein_coding protein_coding 47.61049 35.34438 50.87754 7.95689 1.598626 0.5254236 4.378742 4.686951 0.331706 0.9152541 0.3317060 -3.78089700 0.09957917 0.13840000 0.006566667 -0.131833333 0.03867999 0.03867999 FALSE TRUE
ENST00000562621 ENSG00000159322 HEK293_OSMI2_6hA HEK293_TMG_6hB ADPGK protein_coding retained_intron 47.61049 35.34438 50.87754 7.95689 1.598626 0.5254236 3.182138 3.015314 3.996901 0.8195682 0.2731486 0.40540159 0.06734583 0.08630000 0.078366667 -0.007933333 0.96282081 0.03867999 FALSE TRUE
ENST00000569534 ENSG00000159322 HEK293_OSMI2_6hA HEK293_TMG_6hB ADPGK protein_coding nonsense_mediated_decay 47.61049 35.34438 50.87754 7.95689 1.598626 0.5254236 6.756666 6.136849 6.193393 1.1468466 0.6329808 0.01321054 0.15095000 0.19430000 0.121233333 -0.073066667 0.74085728 0.03867999 FALSE TRUE
MSTRG.11173.8 ENSG00000159322 HEK293_OSMI2_6hA HEK293_TMG_6hB ADPGK protein_coding   47.61049 35.34438 50.87754 7.95689 1.598626 0.5254236 4.907409 1.628942 9.662668 1.6289423 0.3371313 2.56114882 0.09043333 0.03226667 0.190000000 0.157733333 0.15843141 0.03867999 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159322 E001 1.154588 0.0153787590 0.03989836   15 72751294 72751368 75 - 0.116 0.483 2.732
ENSG00000159322 E002 6.932486 0.0170190690 0.03498174 0.14153968 15 72751369 72751371 3 - 0.724 1.010 1.103
ENSG00000159322 E003 1085.702277 0.0021220624 0.01740897 0.08695763 15 72751372 72752429 1058 - 3.004 3.065 0.202
ENSG00000159322 E004 409.457247 0.0001678896 0.95013588 0.97714007 15 72752430 72752634 205 - 2.601 2.613 0.041
ENSG00000159322 E005 498.417945 0.0011380165 0.97803478 0.99078074 15 72752635 72752892 258 - 2.685 2.703 0.057
ENSG00000159322 E006 71.462981 0.0097131378 0.88824436 0.94571463 15 72752893 72752895 3 - 1.849 1.861 0.042
ENSG00000159322 E007 238.270209 0.0022490079 0.67207619 0.81762561 15 72755556 72755635 80 - 2.373 2.375 0.009
ENSG00000159322 E008 136.819105 0.0003345918 0.25758317 0.49633561 15 72755636 72755654 19 - 2.141 2.120 -0.071
ENSG00000159322 E009 15.541907 0.0028458782 0.04844058 0.17603195 15 72755655 72755981 327 - 1.113 1.302 0.669
ENSG00000159322 E010 8.330660 0.0280261384 0.02199838 0.10257474 15 72755982 72756161 180 - 0.795 1.107 1.174
ENSG00000159322 E011 6.212311 0.0052142912 0.05087215 0.18173838 15 72756162 72756250 89 - 0.698 0.962 1.033
ENSG00000159322 E012 113.727357 0.0004196467 0.59649228 0.76800337 15 72756251 72756260 10 - 2.053 2.049 -0.015
ENSG00000159322 E013 337.418772 0.0013873605 0.01566395 0.08059197 15 72756261 72756447 187 - 2.542 2.503 -0.131
ENSG00000159322 E014 223.433750 0.0200348365 0.58631572 0.76118534 15 72756448 72758610 2163 - 2.354 2.348 -0.020
ENSG00000159322 E015 18.479563 0.0021607239 0.01817374 0.08959617 15 72760223 72760248 26 - 1.363 1.184 -0.629
ENSG00000159322 E016 28.903480 0.0013525485 0.03566287 0.14335855 15 72760249 72760406 158 - 1.525 1.400 -0.430
ENSG00000159322 E017 147.292639 0.0019144388 0.05492672 0.19118303 15 72760407 72760417 11 - 2.186 2.140 -0.155
ENSG00000159322 E018 151.023195 0.0003440817 0.01977582 0.09512024 15 72760418 72760442 25 - 2.200 2.145 -0.182
ENSG00000159322 E019 203.766995 0.0004945463 0.17133411 0.39228362 15 72760443 72760527 85 - 2.313 2.292 -0.069
ENSG00000159322 E020 173.184735 0.0015400336 0.03087027 0.12995740 15 72771783 72771845 63 - 2.260 2.210 -0.168
ENSG00000159322 E021 223.091604 0.0062149351 0.54947900 0.73592698 15 72774872 72775097 226 - 2.347 2.350 0.010
ENSG00000159322 E022 1.244946 0.0151384765 0.91111615   15 72775098 72775114 17 - 0.348 0.372 0.146
ENSG00000159322 E023 2.042176 0.0109147750 0.20978888 0.44161596 15 72780197 72780262 66 - 0.575 0.372 -1.023
ENSG00000159322 E024 9.602585 0.2317738521 0.39528157 0.62457922 15 72783246 72783301 56 - 0.926 1.116 0.698
ENSG00000159322 E025 10.964021 0.1754962009 0.07058320 0.22588382 15 72783302 72783458 157 - 0.862 1.236 1.371
ENSG00000159322 E026 84.331922 0.8257004438 0.23326229 0.46890542 15 72783459 72783785 327 - 1.705 2.089 1.292
ENSG00000159322 E027 0.000000       15 72785649 72785846 198 -