ENSG00000159314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376922 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding protein_coding 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 0.8294936 1.52092287 0.00000000 0.17901938 0.000000000 -7.258258 0.15703333 0.24120000 0.00000000 -0.241200000 1.081681e-07 1.081681e-07 FALSE TRUE
ENST00000526484 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding retained_intron 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 0.1206722 0.07850053 0.22329200 0.07850053 0.089198142 1.398379 0.02838750 0.01283333 0.08883333 0.076000000 2.327777e-01 1.081681e-07   FALSE
ENST00000532038 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding protein_coding 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 2.1055657 2.91834748 1.33952061 0.58429097 0.030329655 -1.117640 0.45881250 0.45106667 0.56716667 0.116100000 7.619615e-01 1.081681e-07 FALSE TRUE
ENST00000581638 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding retained_intron 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 0.3278608 0.43962353 0.12443738 0.15933289 0.009197421 -1.741783 0.07229583 0.06810000 0.05203333 -0.016066667 9.410278e-01 1.081681e-07 TRUE FALSE
ENST00000581991 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding retained_intron 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 0.3006967 0.19367823 0.07410711 0.09715334 0.074107111 -1.275992 0.06557083 0.03183333 0.03030000 -0.001533333 9.334349e-01 1.081681e-07 FALSE FALSE
ENST00000590026 ENSG00000159314 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP27 protein_coding retained_intron 4.647991 6.40023 2.410383 0.315893 0.2147279 -1.405141 0.2295554 0.12420600 0.34608497 0.12420600 0.234236393 1.407772 0.05018333 0.02030000 0.12910000 0.108800000 6.063866e-01 1.081681e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159314 E001 0.0000000       17 45393902 45393907 6 -      
ENSG00000159314 E002 0.0000000       17 45393908 45393908 1 -      
ENSG00000159314 E003 0.6486114 0.019197450 0.8002825279   17 45393909 45393938 30 - 0.217 0.171 -0.427
ENSG00000159314 E004 120.5268826 0.000402706 0.9858317939 0.994741585 17 45393939 45394942 1004 - 1.989 1.987 -0.009
ENSG00000159314 E005 61.8545018 0.007237340 0.8113484716 0.903041963 17 45394943 45395246 304 - 1.712 1.691 -0.071
ENSG00000159314 E006 29.3640555 0.005190049 0.1939995553 0.422130365 17 45395247 45395426 180 - 1.470 1.364 -0.367
ENSG00000159314 E007 12.3654249 0.004036480 0.6421810452 0.798286498 17 45395427 45395454 28 - 1.003 1.057 0.197
ENSG00000159314 E008 9.7413775 0.027844369 0.4784770115 0.686057026 17 45395455 45395455 1 - 1.029 0.934 -0.354
ENSG00000159314 E009 28.8078124 0.018268483 0.2240418904 0.458234530 17 45395456 45395633 178 - 1.471 1.361 -0.380
ENSG00000159314 E010 23.7914527 0.001908891 0.5194127785 0.714641791 17 45395744 45395849 106 - 1.350 1.295 -0.191
ENSG00000159314 E011 0.9742192 0.033212201 0.1088496409   17 45395850 45395908 59 - 0.469 0.171 -2.016
ENSG00000159314 E012 21.7388474 0.001658474 0.2869760885 0.527727538 17 45395983 45396062 80 - 1.184 1.282 0.346
ENSG00000159314 E013 17.9210730 0.002021835 0.2301515272 0.465305840 17 45396063 45396117 55 - 1.080 1.202 0.438
ENSG00000159314 E014 1.1298377 0.014276330 0.5881211664   17 45396118 45396163 46 - 0.361 0.256 -0.692
ENSG00000159314 E015 18.8294452 0.002053204 0.0883854964 0.260773991 17 45396207 45396284 78 - 1.056 1.232 0.629
ENSG00000159314 E016 3.7946690 0.021979174 0.7139551197 0.844318753 17 45396285 45396486 202 - 0.556 0.623 0.301
ENSG00000159314 E017 13.9882425 0.003439643 0.5126621897 0.709943824 17 45396487 45396585 99 - 1.030 1.104 0.266
ENSG00000159314 E018 17.9427185 0.002024045 0.5593948257 0.742892392 17 45396668 45396790 123 - 1.145 1.202 0.202
ENSG00000159314 E019 23.0280732 0.147909288 0.3658785092 0.600670089 17 45396916 45397024 109 - 1.174 1.307 0.469
ENSG00000159314 E020 1.6489860 0.012198908 0.4002368630 0.628454905 17 45397205 45397228 24 - 0.217 0.388 1.157
ENSG00000159314 E021 3.1167456 0.125363500 0.5707149138 0.750804333 17 45397514 45397948 435 - 0.625 0.516 -0.499
ENSG00000159314 E022 13.7270558 0.101205699 0.9752657542 0.989481381 17 45397949 45397964 16 - 1.115 1.067 -0.172
ENSG00000159314 E023 23.5878617 0.003953939 0.8592805817 0.929969530 17 45397965 45398047 83 - 1.282 1.294 0.041
ENSG00000159314 E024 2.0045441 0.019998058 0.0007036282 0.007473404 17 45401580 45401668 89 - 0.792 0.216 -3.009
ENSG00000159314 E025 18.3551837 0.001910668 0.1830663442 0.407904846 17 45402714 45402773 60 - 1.080 1.215 0.484
ENSG00000159314 E026 18.9149855 0.002114538 0.0803593028 0.245566334 17 45402774 45402818 45 - 1.056 1.236 0.644
ENSG00000159314 E027 22.3422484 0.001562177 0.3318260019 0.570673112 17 45403619 45403709 91 - 1.202 1.289 0.308
ENSG00000159314 E028 0.5061644 0.290779409 0.5898942671   17 45403710 45404028 319 - 0.217 0.122 -0.997
ENSG00000159314 E029 24.4625832 0.001475575 0.4575124065 0.671431047 17 45404029 45404096 68 - 1.363 1.300 -0.219
ENSG00000159314 E030 0.4812263 0.022578585 0.5636814637   17 45404097 45404186 90 - 0.217 0.121 -1.016
ENSG00000159314 E031 2.7428544 0.048306363 0.4049151094 0.632195446 17 45404269 45404334 66 - 0.361 0.533 0.896
ENSG00000159314 E032 19.1367600 0.002104688 0.0762599748 0.237259949 17 45404445 45404474 30 - 1.337 1.179 -0.557
ENSG00000159314 E033 22.1727787 0.001981324 0.0223686271 0.103801163 17 45404475 45404528 54 - 1.420 1.231 -0.658
ENSG00000159314 E034 0.5657866 0.021674798 0.1817248901   17 45404529 45404600 72 - 0.361 0.121 -2.017
ENSG00000159314 E035 22.5957337 0.004291233 0.2603853527 0.499347641 17 45404601 45404681 81 - 1.363 1.265 -0.341
ENSG00000159314 E036 0.7491197 0.017710250 1.0000000000   17 45404682 45404923 242 - 0.217 0.215 -0.015
ENSG00000159314 E037 20.4405949 0.001808767 0.7803574084 0.884970992 17 45404924 45405027 104 - 1.219 1.244 0.086
ENSG00000159314 E038 18.7003128 0.006941017 0.8796524360 0.941092094 17 45405028 45405106 79 - 1.184 1.195 0.040
ENSG00000159314 E039 20.7230097 0.018583235 0.4958255521 0.698081435 17 45405676 45405846 171 - 1.183 1.255 0.256
ENSG00000159314 E040 22.5985087 0.001939306 0.0745546998 0.233910176 17 45405847 45406083 237 - 1.145 1.313 0.593
ENSG00000159314 E041 0.1614157 0.032225219 0.1070068942   17 45407533 45410231 2699 - 0.217 0.000 -12.434
ENSG00000159314 E042 0.1723744 0.032443085 1.0000000000   17 45410232 45410426 195 - 0.000 0.065 9.120
ENSG00000159314 E043 6.7159108 0.004645455 0.0254461915 0.113582830 17 45425564 45425734 171 - 0.469 0.851 1.650
ENSG00000159314 E044 0.0000000       17 45429352 45429352 1 -      
ENSG00000159314 E045 0.2617363 0.113085350 1.0000000000   17 45429353 45429622 270 - 0.000 0.119 9.843
ENSG00000159314 E046 6.9776761 0.005145341 0.5065217237 0.705305335 17 45429623 45430297 675 - 0.743 0.841 0.386
ENSG00000159314 E047 3.1595418 0.008149307 0.9066487897 0.955425788 17 45431621 45431752 132 - 0.556 0.533 -0.106
ENSG00000159314 E048 1.5528021 0.013299980 0.9888607004 0.996257360 17 45432216 45432349 134 - 0.361 0.358 -0.017
ENSG00000159314 E049 4.5101726 0.046254880 0.1739163570 0.395762951 17 45432752 45433746 995 - 0.836 0.607 -0.943
ENSG00000159314 E050 0.9624527 0.099898864 0.4600681498   17 45434310 45434421 112 - 0.363 0.214 -1.035