ENSG00000159217

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290341 ENSG00000159217 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF2BP1 protein_coding protein_coding 40.93432 44.95759 42.9814 2.216102 1.65591 -0.06483744 26.119645 27.479305 34.8199706 2.9530937 1.5491926 0.3414588 0.6323917 0.60926667 0.809966667 0.20070000 2.076589e-02 1.823906e-27 FALSE TRUE
ENST00000431824 ENSG00000159217 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF2BP1 protein_coding protein_coding 40.93432 44.95759 42.9814 2.216102 1.65591 -0.06483744 4.546067 3.078363 0.3189382 1.5524327 0.1647560 -3.2309540 0.1167042 0.07073333 0.007133333 -0.06360000 7.800188e-01 1.823906e-27 FALSE TRUE
MSTRG.14614.3 ENSG00000159217 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF2BP1 protein_coding   40.93432 44.95759 42.9814 2.216102 1.65591 -0.06483744 4.789441 5.758486 6.5934783 0.5671198 0.4856241 0.1950334 0.1167250 0.12806667 0.153633333 0.02556667 7.355432e-01 1.823906e-27 FALSE TRUE
MSTRG.14614.6 ENSG00000159217 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF2BP1 protein_coding   40.93432 44.95759 42.9814 2.216102 1.65591 -0.06483744 3.249979 7.223036 0.0000000 1.1188200 0.0000000 -9.4984576 0.0797250 0.15906667 0.000000000 -0.15906667 1.823906e-27 1.823906e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159217 E001 0.0000000       17 48997165 48997179 15 +      
ENSG00000159217 E002 0.7499275 0.0172671820 5.268221e-01   17 48997180 48997184 5 + 0.294 0.216 -0.585
ENSG00000159217 E003 5.9836058 0.0501517794 7.231050e-01 8.500142e-01 17 48997185 48997238 54 + 0.786 0.895 0.424
ENSG00000159217 E004 2.8036646 0.1296091769 4.834416e-01 6.893904e-01 17 48997385 48997403 19 + 0.467 0.699 1.050
ENSG00000159217 E005 3.8815850 0.1187257986 3.271109e-01 5.662205e-01 17 48997404 48997417 14 + 0.551 0.818 1.128
ENSG00000159217 E006 6.4475761 0.0236783037 1.061283e-01 2.925720e-01 17 48997418 48997419 2 + 0.714 1.000 1.110
ENSG00000159217 E007 75.5158108 0.9031612024 5.962239e-01 7.678243e-01 17 48997420 48997485 66 + 1.831 1.930 0.335
ENSG00000159217 E008 214.6553946 0.0100340786 9.650996e-01 9.844734e-01 17 48997486 48997677 192 + 2.297 2.369 0.243
ENSG00000159217 E009 169.3502640 0.0018331763 2.650672e-01 5.043925e-01 17 48997678 48997745 68 + 2.171 2.285 0.381
ENSG00000159217 E010 128.2249967 0.0013092916 9.195213e-01 9.619857e-01 17 48997746 48997762 17 + 2.070 2.149 0.265
ENSG00000159217 E011 287.0312315 0.0002540826 5.372234e-03 3.655887e-02 17 48997763 48997920 158 + 2.452 2.468 0.050
ENSG00000159217 E012 216.2898380 0.0004285687 7.341094e-09 3.549791e-07 17 48999109 48999169 61 + 2.372 2.300 -0.241
ENSG00000159217 E013 1.4479695 0.0848758389 6.212130e-02 2.075635e-01 17 49004601 49004858 258 + 0.122 0.519 2.836
ENSG00000159217 E014 0.1723744 0.0335272747 5.668623e-01   17 49013917 49014035 119 + 0.000 0.122 9.085
ENSG00000159217 E015 213.2120253 0.0002133640 1.195549e-07 4.355968e-06 17 49025618 49025666 49 + 2.358 2.303 -0.184
ENSG00000159217 E016 0.0000000       17 49026392 49026465 74 +      
ENSG00000159217 E017 217.8122157 0.0009508339 2.459496e-05 4.553142e-04 17 49026466 49026517 52 + 2.361 2.319 -0.139
ENSG00000159217 E018 269.1682361 0.0002075732 1.516194e-07 5.388961e-06 17 49031910 49031973 64 + 2.452 2.412 -0.135
ENSG00000159217 E019 7.5500767 0.0517687002 1.712028e-01 3.921045e-01 17 49036550 49036933 384 + 1.002 0.880 -0.458
ENSG00000159217 E020 444.5947207 0.0001497007 3.841888e-10 2.408420e-08 17 49038168 49038449 282 + 2.665 2.633 -0.108
ENSG00000159217 E021 322.8537207 0.0002662419 9.600876e-14 1.198860e-11 17 49039957 49040091 135 + 2.548 2.469 -0.264
ENSG00000159217 E022 361.1089803 0.0020862721 8.663660e-08 3.264452e-06 17 49041378 49041500 123 + 2.597 2.518 -0.263
ENSG00000159217 E023 356.5303414 0.0027923773 7.192657e-05 1.135731e-03 17 49042242 49042377 136 + 2.578 2.528 -0.166
ENSG00000159217 E024 253.6001373 0.0002364632 3.185049e-04 3.916120e-03 17 49043428 49043550 123 + 2.410 2.403 -0.024
ENSG00000159217 E025 101.0448502 0.0003827924 5.473655e-02 1.907518e-01 17 49043967 49043969 3 + 2.006 2.012 0.022
ENSG00000159217 E026 304.2237247 0.0002246871 2.271844e-07 7.710060e-06 17 49043970 49044086 117 + 2.500 2.466 -0.112
ENSG00000159217 E027 324.2866091 0.0001691493 1.382552e-14 1.986371e-12 17 49044991 49045065 75 + 2.550 2.470 -0.265
ENSG00000159217 E028 477.6920932 0.0001410744 2.784627e-18 6.632449e-16 17 49045890 49046021 132 + 2.714 2.644 -0.232
ENSG00000159217 E029 460.7754947 0.0001437232 1.022099e-13 1.269758e-11 17 49046260 49046373 114 + 2.689 2.638 -0.169
ENSG00000159217 E030 7660.7401510 0.0008298164 5.462609e-31 4.781838e-28 17 49049352 49056145 6794 + 3.801 3.953 0.504