ENSG00000159140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300278 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding protein_coding 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 7.601287 9.492448 7.6662971 1.7606385 0.09744636 -0.3078886 0.05818333 0.08140000 0.0504000000 -0.03100000 9.784946e-03 6.29428e-56 FALSE TRUE
ENST00000356577 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding protein_coding 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 17.314185 6.558476 33.4420205 2.7686719 1.34691980 2.3484629 0.12206250 0.06206667 0.2196000000 0.15753333 1.503136e-01 6.29428e-56 FALSE TRUE
ENST00000381679 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding protein_coding 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 17.425183 18.268417 15.5515827 4.5038969 0.62061982 -0.2321523 0.13041667 0.15110000 0.1020333333 -0.04906667 1.813487e-02 6.29428e-56 FALSE TRUE
ENST00000381692 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding protein_coding 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 15.359815 23.073983 0.0000000 8.0296174 0.00000000 -11.1726765 0.11945417 0.17920000 0.0000000000 -0.17920000 5.311852e-24 6.29428e-56 FALSE TRUE
ENST00000429093 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding nonsense_mediated_decay 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 6.229821 2.450194 11.7733180 0.5835854 0.23342346 2.2599017 0.04548333 0.02590000 0.0773333333 0.05143333 1.463436e-01 6.29428e-56   FALSE
ENST00000436227 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding protein_coding 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 18.875187 29.786814 15.9562702 8.3826559 0.53202419 -0.9001307 0.14517500 0.24136667 0.1049000000 -0.13646667 1.853950e-04 6.29428e-56 FALSE TRUE
ENST00000478183 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding retained_intron 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 7.000731 4.585196 10.5327973 0.6448001 0.59415492 1.1980595 0.05439583 0.04650000 0.0694333333 0.02293333 6.676097e-01 6.29428e-56 FALSE TRUE
ENST00000491794 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding retained_intron 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 7.962508 5.537073 0.0997464 2.5530820 0.09974640 -5.6594812 0.06052917 0.03986667 0.0006333333 -0.03923333 1.790792e-02 6.29428e-56 FALSE TRUE
ENST00000492229 ENSG00000159140 HEK293_OSMI2_6hA HEK293_TMG_6hB SON protein_coding processed_transcript 134.3472 118.5135 152.3178 25.08886 3.587751 0.3620053 12.330902 0.000000 24.0079742 0.0000000 1.57052233 11.2298988 0.08332500 0.00000000 0.1573333333 0.15733333 6.294280e-56 6.29428e-56   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159140 E001 3.6903775 0.007758307 4.875876e-01 6.923609e-01 21 33542968 33543037 70 + 0.724 0.618 -0.447
ENSG00000159140 E002 15.5710953 0.022366150 2.494367e-02 1.120460e-01 21 33543038 33543051 14 + 1.334 1.095 -0.844
ENSG00000159140 E003 18.7160306 0.025314347 6.186497e-03 4.064253e-02 21 33543052 33543056 5 + 1.429 1.135 -1.031
ENSG00000159140 E004 22.6207863 0.030896105 1.241143e-02 6.809502e-02 21 33543057 33543063 7 + 1.499 1.223 -0.960
ENSG00000159140 E005 25.3364125 0.036473574 4.788376e-03 3.346818e-02 21 33543064 33543064 1 + 1.563 1.238 -1.127
ENSG00000159140 E006 29.4927040 0.023908010 4.611689e-04 5.322624e-03 21 33543065 33543069 5 + 1.635 1.285 -1.206
ENSG00000159140 E007 266.8315679 0.015801303 7.514231e-05 1.177639e-03 21 33543070 33543169 100 + 2.545 2.282 -0.876
ENSG00000159140 E008 409.1388395 0.019088181 1.809114e-04 2.459014e-03 21 33546213 33546379 167 + 2.731 2.466 -0.883
ENSG00000159140 E009 0.0000000       21 33546380 33546752 373 +      
ENSG00000159140 E010 0.1308682 0.032649190 5.067633e-01   21 33547001 33547039 39 + 0.001 0.119 8.049
ENSG00000159140 E011 1587.5597428 0.005905874 6.015807e-05 9.756684e-04 21 33549476 33550661 1186 + 3.275 3.119 -0.516
ENSG00000159140 E012 294.8044991 1.553356294 6.177693e-01 7.822692e-01 21 33550662 33550728 67 + 2.456 2.484 0.094
ENSG00000159140 E013 2147.4985362 0.004237570 5.829210e-06 1.317277e-04 21 33550729 33552247 1519 + 3.402 3.256 -0.484
ENSG00000159140 E014 5658.1607645 0.014179276 3.681762e-02 1.464322e-01 21 33552248 33555048 2801 + 3.795 3.709 -0.285
ENSG00000159140 E015 667.5219318 0.006847819 4.223808e-01 6.454175e-01 21 33555049 33555391 343 + 2.802 2.845 0.142
ENSG00000159140 E016 803.8123231 0.004081053 3.121326e-01 5.524679e-01 21 33557156 33557316 161 + 2.884 2.924 0.131
ENSG00000159140 E017 808.8590345 0.011963115 5.714682e-03 3.831045e-02 21 33557546 33559229 1684 + 2.814 2.980 0.553
ENSG00000159140 E018 684.3621415 0.020284146 4.523244e-02 1.681923e-01 21 33559230 33559376 147 + 2.768 2.891 0.410
ENSG00000159140 E019 772.0019895 0.171734251 1.502876e-01 3.627076e-01 21 33559587 33559775 189 + 2.778 2.970 0.636
ENSG00000159140 E020 195.4047196 0.004166134 7.927452e-10 4.715459e-08 21 33559877 33560667 791 + 2.142 2.396 0.851
ENSG00000159140 E021 233.0173325 0.010871746 1.017991e-02 5.888772e-02 21 33567157 33567159 3 + 2.293 2.431 0.460
ENSG00000159140 E022 327.4023714 0.015846526 8.157020e-03 5.004876e-02 21 33567160 33567178 19 + 2.425 2.587 0.541
ENSG00000159140 E023 314.3627121 0.011265415 3.792048e-03 2.797710e-02 21 33567179 33567184 6 + 2.414 2.566 0.506
ENSG00000159140 E024 500.4012257 0.012754947 2.115312e-03 1.784366e-02 21 33567185 33567267 83 + 2.606 2.773 0.558
ENSG00000159140 E025 1.8362202 0.044931903 7.258513e-01 8.516340e-01 21 33567268 33567467 200 + 0.475 0.411 -0.331
ENSG00000159140 E026 551.1590567 0.032873968 2.259364e-02 1.045767e-01 21 33568971 33569087 117 + 2.641 2.819 0.592
ENSG00000159140 E027 48.7303409 0.240478644 1.507595e-02 7.836919e-02 21 33569088 33569302 215 + 1.898 1.346 -1.884
ENSG00000159140 E028 49.8472313 0.063543508 2.234249e-06 5.750635e-05 21 33569576 33569775 200 + 1.932 1.270 -2.261
ENSG00000159140 E029 55.6332099 0.185277064 3.383293e-03 2.565691e-02 21 33569776 33569930 155 + 1.970 1.349 -2.114
ENSG00000159140 E030 58.1127892 0.183616429 1.180038e-02 6.564173e-02 21 33570095 33570198 104 + 1.967 1.445 -1.772
ENSG00000159140 E031 25.8715855 0.180699869 5.189036e-02 1.841788e-01 21 33571735 33571750 16 + 1.585 1.202 -1.329
ENSG00000159140 E032 36.9711941 0.123525585 3.348853e-02 1.374498e-01 21 33571751 33571788 38 + 1.735 1.356 -1.295
ENSG00000159140 E033 52.2337995 0.161748831 1.014474e-02 5.874887e-02 21 33571789 33571868 80 + 1.915 1.421 -1.679
ENSG00000159140 E034 47.7024246 0.206110033 2.668907e-02 1.173314e-01 21 33571869 33571903 35 + 1.863 1.417 -1.519
ENSG00000159140 E035 74.7521889 0.125154376 2.576693e-02 1.145832e-01 21 33572213 33572526 314 + 2.035 1.656 -1.278
ENSG00000159140 E036 34.1185621 0.089713272 4.465821e-02 1.667573e-01 21 33572527 33572550 24 + 1.681 1.366 -1.078
ENSG00000159140 E037 87.2384215 0.043315364 4.261874e-01 6.481568e-01 21 33572551 33572630 80 + 1.999 1.893 -0.357
ENSG00000159140 E038 47.3877197 0.120862789 6.046136e-02 2.038623e-01 21 33573025 33573213 189 + 1.820 1.504 -1.074
ENSG00000159140 E039 31.3685776 0.195596798 6.210586e-01 7.845780e-01 21 33573214 33573307 94 + 1.579 1.437 -0.488
ENSG00000159140 E040 688.0433037 0.885721316 3.099685e-01 5.504420e-01 21 33573308 33573455 148 + 2.690 2.941 0.835
ENSG00000159140 E041 458.1575897 1.594096433 4.360512e-01 6.558397e-01 21 33575596 33575667 72 + 2.515 2.764 0.828
ENSG00000159140 E042 426.3517481 0.048886331 1.676347e-02 8.460854e-02 21 33575778 33575893 116 + 2.497 2.726 0.762
ENSG00000159140 E043 117.7698345 0.001109220 1.752910e-09 9.772965e-08 21 33576365 33576417 53 + 1.950 2.167 0.725
ENSG00000159140 E044 2109.4095723 0.011710573 5.504739e-03 3.724725e-02 21 33576418 33577481 1064 + 3.238 3.391 0.508