ENSG00000159082

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382491 ENSG00000159082 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNJ1 protein_coding protein_coding 4.405655 4.249343 6.970956 1.109086 0.3452425 0.7127936 0.2703193 0.1801367 0.6401298 0.02733108 0.3682385 1.773691 0.0514125 0.05146667 0.08736667 0.0359000 9.949767e-01 2.269467e-20 FALSE TRUE
ENST00000438952 ENSG00000159082 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNJ1 protein_coding protein_coding 4.405655 4.249343 6.970956 1.109086 0.3452425 0.7127936 0.7694035 1.6442728 0.0000000 0.49410134 0.0000000 -7.370053 0.2547833 0.37376667 0.00000000 -0.3737667 2.269467e-20 2.269467e-20 FALSE TRUE
ENST00000630077 ENSG00000159082 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNJ1 protein_coding protein_coding 4.405655 4.249343 6.970956 1.109086 0.3452425 0.7127936 3.0263047 2.3099633 5.7024754 0.60080869 0.1489484 1.300014 0.6225875 0.54896667 0.82176667 0.2728000 1.580759e-02 2.269467e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000159082 E001 0.3453689 0.0285449672 7.289228e-01   21 32628759 32628762 4 - 0.086 0.169 1.125
ENSG00000159082 E002 318.3340698 1.5628207328 3.356435e-01 0.5741220811 21 32628763 32631378 2616 - 2.293 2.711 1.393
ENSG00000159082 E003 46.2241405 0.6434478828 3.039886e-01 0.5445607495 21 32631379 32631537 159 - 1.527 1.823 1.002
ENSG00000159082 E004 55.2672108 0.6944129296 3.037775e-01 0.5443467849 21 32631538 32631777 240 - 1.592 1.910 1.077
ENSG00000159082 E005 22.2197911 0.3746331241 2.336239e-01 0.4693270892 21 32631778 32631801 24 - 1.213 1.524 1.080
ENSG00000159082 E006 0.4820342 0.0219518915 1.905376e-01   21 32634861 32634881 21 - 0.219 0.000 -14.371
ENSG00000159082 E007 0.4820342 0.0219518915 1.905376e-01   21 32634882 32634884 3 - 0.219 0.000 -14.371
ENSG00000159082 E008 40.3624485 0.5867295236 2.988132e-01 0.5392820203 21 32638908 32639125 218 - 1.461 1.775 1.068
ENSG00000159082 E009 23.1451243 0.0019951167 6.786987e-02 0.2202998059 21 32639671 32639779 109 - 1.262 1.528 0.923
ENSG00000159082 E010 16.4070430 0.0258962195 7.134698e-01 0.8440396508 21 32641896 32641966 71 - 1.178 1.286 0.383
ENSG00000159082 E011 0.8217936 0.0189014584 9.427406e-01   21 32642095 32642133 39 - 0.219 0.291 0.540
ENSG00000159082 E012 0.6600180 0.0233332329 1.019891e-01   21 32643410 32643457 48 - 0.273 0.000 -14.787
ENSG00000159082 E013 0.6268817 0.0773759086 1.203243e-01   21 32644968 32645006 39 - 0.273 0.000 -14.784
ENSG00000159082 E014 17.6909333 0.0541170338 3.827847e-01 0.6145360332 21 32645646 32645789 144 - 1.141 1.408 0.938
ENSG00000159082 E015 28.5923820 0.0383306127 5.594256e-01 0.7429100006 21 32646393 32646602 210 - 1.369 1.573 0.702
ENSG00000159082 E016 32.0005203 0.0101226525 8.610875e-01 0.9309365655 21 32650184 32650346 163 - 1.436 1.590 0.529
ENSG00000159082 E017 24.3597623 0.0088991894 3.493180e-01 0.5866518500 21 32653288 32653366 79 - 1.355 1.411 0.195
ENSG00000159082 E018 2.5381899 0.4063308629 3.521050e-01 0.5891534007 21 32653367 32654101 735 - 0.580 0.391 -0.941
ENSG00000159082 E019 14.0494937 0.0236309036 7.755457e-01 0.8820845199 21 32656687 32656690 4 - 1.114 1.212 0.348
ENSG00000159082 E020 38.4419352 0.0052860979 3.558988e-01 0.5924246036 21 32656691 32656902 212 - 1.545 1.625 0.275
ENSG00000159082 E021 28.8817491 0.0327478138 9.816403e-02 0.2785707639 21 32657003 32657120 118 - 1.457 1.438 -0.064
ENSG00000159082 E022 34.8256380 0.0195254565 1.766864e-02 0.0878919077 21 32657716 32657872 157 - 1.548 1.490 -0.201
ENSG00000159082 E023 0.1779838 0.1015796498 7.632820e-01   21 32658471 32658561 91 - 0.086 0.000 -12.791
ENSG00000159082 E024 37.6423235 0.0109184407 2.082111e-01 0.4396887661 21 32664913 32665071 159 - 1.545 1.602 0.196
ENSG00000159082 E025 21.6236618 0.0158080869 3.425541e-01 0.5802530415 21 32665943 32665985 43 - 1.311 1.372 0.212
ENSG00000159082 E026 36.8218514 0.0009852855 5.771780e-01 0.7552251315 21 32665986 32666135 150 - 1.523 1.627 0.354
ENSG00000159082 E027 37.4944638 0.0151727100 4.685648e-01 0.6790613435 21 32666433 32666573 141 - 1.529 1.608 0.268
ENSG00000159082 E028 28.2785192 0.0294586129 6.452837e-01 0.8003739950 21 32670288 32670372 85 - 1.405 1.499 0.322
ENSG00000159082 E029 41.7328911 0.0465110643 5.968502e-02 0.2020711588 21 32673340 32673531 192 - 1.619 1.562 -0.196
ENSG00000159082 E030 0.6709767 0.2320074891 6.291385e-01   21 32676332 32676355 24 - 0.220 0.170 -0.466
ENSG00000159082 E031 40.0081053 0.0152292589 1.875028e-03 0.0162295025 21 32678645 32678801 157 - 1.621 1.507 -0.390
ENSG00000159082 E032 15.8301979 0.0203123139 2.068670e-03 0.0175233282 21 32678802 32678810 9 - 1.262 1.054 -0.741
ENSG00000159082 E033 35.7460299 0.0212055766 1.530881e-02 0.0792374383 21 32681496 32681648 153 - 1.566 1.470 -0.328
ENSG00000159082 E034 22.8248492 0.0315030412 3.337256e-02 0.1371030563 21 32684038 32684119 82 - 1.378 1.270 -0.374
ENSG00000159082 E035 30.2122275 0.0430856330 1.061007e-01 0.2925196842 21 32685748 32685917 170 - 1.479 1.440 -0.133
ENSG00000159082 E036 30.7138719 0.0137093772 1.387539e-02 0.0738509067 21 32686978 32687074 97 - 1.496 1.425 -0.245
ENSG00000159082 E037 28.5737959 0.0051119449 2.565500e-04 0.0032893990 21 32688306 32688367 62 - 1.487 1.341 -0.505
ENSG00000159082 E038 31.5442433 0.0091517227 2.206177e-03 0.0184406930 21 32694228 32694311 84 - 1.517 1.416 -0.346
ENSG00000159082 E039 41.8479194 0.0294257855 1.430163e-03 0.0131141819 21 32695057 32695225 169 - 1.656 1.471 -0.630
ENSG00000159082 E040 21.9793889 0.0022672426 3.259496e-05 0.0005792563 21 32695226 32695282 57 - 1.395 1.184 -0.740
ENSG00000159082 E041 33.6083121 0.0011470305 1.146973e-05 0.0002357856 21 32699838 32700105 268 - 1.561 1.410 -0.519
ENSG00000159082 E042 24.4864715 0.0017230839 5.911761e-03 0.0393090451 21 32701961 32702047 87 - 1.410 1.340 -0.241
ENSG00000159082 E043 26.4960570 0.0112196466 2.348903e-02 0.1075109070 21 32726772 32726917 146 - 1.431 1.382 -0.170
ENSG00000159082 E044 0.0000000       21 32726918 32726942 25 -      
ENSG00000159082 E045 0.7990684 0.0172671820 9.556346e-01   21 32727205 32727266 62 - 0.219 0.290 0.536
ENSG00000159082 E046 6.4666872 0.0812686232 1.736616e-01 0.3954111439 21 32727837 32727939 103 - 0.882 0.785 -0.378
ENSG00000159082 E047 4.1187294 0.0064358261 9.887929e-02 0.2798243343 21 32727946 32728040 95 - 0.730 0.586 -0.614