ENSG00000158856

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432128 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding protein_coding 3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.007290688 0.00000000 0.05832550 0.00000000 0.05832550 2.772424 0.006370833 0.00000000 0.05096667 0.05096667 0.6722490117 0.0001054975 FALSE TRUE
ENST00000443491 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding protein_coding 3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.139626395 0.00000000 0.28921822 0.00000000 0.10346262 4.903126 0.076558333 0.00000000 0.23506667 0.23506667 0.0001054975 0.0001054975 FALSE TRUE
ENST00000517804 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding protein_coding 3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.024788703 0.00000000 0.16345820 0.00000000 0.16345820 4.116516 0.015912500 0.00000000 0.12246667 0.12246667 0.7051651684 0.0001054975 FALSE FALSE
ENST00000523782 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding protein_coding 3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.248093680 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.076833333 0.00000000 0.00000000 0.00000000   0.0001054975 FALSE TRUE
MSTRG.31237.1 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.302207529 0.38025912 0.02739747 0.38025912 0.02739747 -3.383420 0.094933333 0.06756667 0.02393333 -0.04363333 0.9688064534 0.0001054975 FALSE TRUE
MSTRG.31237.2 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.290013503 0.07625604 0.00000000 0.07625604 0.00000000 -3.108626 0.079962500 0.03063333 0.00000000 -0.03063333 1.0000000000 0.0001054975 FALSE TRUE
MSTRG.31237.4 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.384528346 1.38651634 0.00000000 0.46635418 0.00000000 -7.125689 0.088700000 0.30450000 0.00000000 -0.30450000 0.0001087386 0.0001054975 FALSE TRUE
MSTRG.31237.5 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 1.367168704 2.18853343 0.52875795 0.50171573 0.30303032 -2.028832 0.320791667 0.47413333 0.46403333 -0.01010000 1.0000000000 0.0001054975 FALSE TRUE
MSTRG.31237.6 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.152259821 0.37607503 0.13821055 0.37607503 0.13821055 -1.381233 0.057783333 0.06683333 0.10353333 0.03670000 0.9467849181 0.0001054975 FALSE TRUE
MSTRG.31237.9 ENSG00000158856 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTN protein_coding   3.629361 4.713446 1.205368 1.11834 0.06472871 -1.958447 0.329690077 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.090437500 0.00000000 0.00000000 0.00000000   0.0001054975 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000158856 E001 0.7014564 0.396833031 0.58303549   8 22048978 22048994 17 + 0.249 0.178 -0.612
ENSG00000158856 E002 0.8738308 0.091096271 0.82761308   8 22048995 22049054 60 + 0.247 0.222 -0.202
ENSG00000158856 E003 2.3198949 0.013436991 0.36991053 0.60389310 8 22049055 22049145 91 + 0.247 0.462 1.311
ENSG00000158856 E004 1.2736898 0.013324319 0.25134706   8 22049146 22049148 3 + 0.000 0.320 12.199
ENSG00000158856 E005 1.3455559 0.013489102 0.24977049   8 22049149 22049156 8 + 0.000 0.320 12.201
ENSG00000158856 E006 3.9096913 0.007304408 0.10691955 0.29388037 8 22049157 22049224 68 + 0.247 0.616 2.033
ENSG00000158856 E007 0.0000000       8 22053555 22053569 15 +      
ENSG00000158856 E008 0.0000000       8 22053570 22053786 217 +      
ENSG00000158856 E009 0.0000000       8 22054777 22054816 40 +      
ENSG00000158856 E010 0.1779838 0.035397734 0.06151323   8 22054817 22054901 85 + 0.247 0.000 -14.168
ENSG00000158856 E011 0.1779838 0.035397734 0.06151323   8 22054902 22054906 5 + 0.247 0.000 -14.168
ENSG00000158856 E012 0.1779838 0.035397734 0.06151323   8 22054907 22054930 24 + 0.247 0.000 -14.168
ENSG00000158856 E013 0.0000000       8 22054931 22054942 12 +      
ENSG00000158856 E014 0.0000000       8 22054943 22054952 10 +      
ENSG00000158856 E015 0.0000000       8 22054953 22055007 55 +      
ENSG00000158856 E016 0.0000000       8 22055457 22055555 99 +      
ENSG00000158856 E017 0.0000000       8 22056814 22056904 91 +      
ENSG00000158856 E018 0.0000000       8 22056905 22056965 61 +      
ENSG00000158856 E019 0.5255656 0.313649403 0.07563166   8 22056966 22057136 171 + 0.404 0.057 -3.463
ENSG00000158856 E020 0.0000000       8 22057865 22057887 23 +      
ENSG00000158856 E021 0.1614157 0.034509938 0.06151291   8 22057888 22057965 78 + 0.247 0.000 -14.169
ENSG00000158856 E022 0.0000000       8 22059206 22059222 17 +      
ENSG00000158856 E023 0.0000000       8 22059223 22059347 125 +      
ENSG00000158856 E024 0.0000000       8 22059348 22059372 25 +      
ENSG00000158856 E025 0.1614157 0.034509938 0.06151291   8 22059373 22059496 124 + 0.247 0.000 -14.169
ENSG00000158856 E026 0.2027342 0.034068698 0.97159197   8 22066498 22066515 18 + 0.000 0.056 9.447
ENSG00000158856 E027 0.4054685 0.419470360 1.00000000   8 22066516 22066704 189 + 0.000 0.109 10.342
ENSG00000158856 E028 7.1627705 0.005567363 0.33877163 0.57691019 8 22066705 22066837 133 + 0.608 0.800 0.796
ENSG00000158856 E029 6.9907266 0.058806393 0.42902554 0.65033782 8 22066838 22066893 56 + 0.851 0.760 -0.358
ENSG00000158856 E030 5.5770039 0.004994264 0.07521674 0.23525302 8 22067085 22067159 75 + 0.896 0.657 -0.960
ENSG00000158856 E031 18.2742921 0.002024829 0.07023402 0.22522845 8 22067527 22067682 156 + 1.269 1.122 -0.523
ENSG00000158856 E032 10.4033924 0.003679355 0.56353024 0.74577031 8 22069016 22069060 45 + 0.974 0.928 -0.171
ENSG00000158856 E033 0.3751086 0.030619635 1.00000000   8 22069061 22069418 358 + 0.000 0.105 10.396
ENSG00000158856 E034 19.4029852 0.022035884 0.92497467 0.96480971 8 22069419 22069518 100 + 1.123 1.180 0.205
ENSG00000158856 E035 19.1654469 0.002696558 0.92577879 0.96505187 8 22069881 22069937 57 + 1.146 1.168 0.079
ENSG00000158856 E036 33.8902553 0.001489146 0.14273389 0.35152787 8 22070182 22070334 153 + 1.467 1.387 -0.275
ENSG00000158856 E037 35.1851716 0.015544903 0.16996197 0.39040538 8 22072326 22072450 125 + 1.500 1.403 -0.334
ENSG00000158856 E038 28.6292170 0.009570583 0.39817117 0.62682780 8 22073730 22073835 106 + 1.379 1.329 -0.173
ENSG00000158856 E039 24.4549698 0.002883075 0.56050138 0.74365262 8 22080180 22080244 65 + 1.287 1.262 -0.089
ENSG00000158856 E040 22.6157044 0.002787702 0.70746770 0.84022860 8 22080412 22080460 49 + 1.169 1.236 0.236
ENSG00000158856 E041 15.1622274 0.010484779 0.10948828 0.29823118 8 22080618 22080625 8 + 0.852 1.096 0.908
ENSG00000158856 E042 8.2939406 0.005099157 0.01717607 0.08608465 8 22080805 22080870 66 + 0.403 0.877 2.096
ENSG00000158856 E043 25.5856748 0.046656879 0.29811205 0.53859495 8 22081113 22081193 81 + 1.143 1.304 0.569
ENSG00000158856 E044 78.2413493 0.468447053 0.35342220 0.59034169 8 22081350 22082527 1178 + 1.581 1.777 0.663