ENSG00000158201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289119 ENSG00000158201 HEK293_OSMI2_6hA HEK293_TMG_6hB ABHD3 protein_coding protein_coding 15.62489 6.849714 23.14426 0.4645491 0.5995396 1.755057 10.6852050 3.9749472 16.4109615 0.5193287 0.7922343 2.0429061 0.64082917 0.58780000 0.70830000 0.12050000 0.69011094 0.03711545 FALSE TRUE
ENST00000579875 ENSG00000158201 HEK293_OSMI2_6hA HEK293_TMG_6hB ABHD3 protein_coding processed_transcript 15.62489 6.849714 23.14426 0.4645491 0.5995396 1.755057 0.3904897 0.4266932 0.2508527 0.1062111 0.1258990 -0.7433845 0.03233333 0.06400000 0.01060000 -0.05340000 0.25296171 0.03711545 FALSE TRUE
MSTRG.15554.3 ENSG00000158201 HEK293_OSMI2_6hA HEK293_TMG_6hB ABHD3 protein_coding   15.62489 6.849714 23.14426 0.4645491 0.5995396 1.755057 1.1970671 1.4033589 1.6175315 0.3684150 0.1497748 0.2035576 0.10464167 0.19973333 0.06963333 -0.13010000 0.03711545 0.03711545 TRUE TRUE
MSTRG.15554.6 ENSG00000158201 HEK293_OSMI2_6hA HEK293_TMG_6hB ABHD3 protein_coding   15.62489 6.849714 23.14426 0.4645491 0.5995396 1.755057 2.5604850 0.7128327 3.9051220 0.3233808 0.6718464 2.4373236 0.16038333 0.09996667 0.17023333 0.07026667 0.68857969 0.03711545 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000158201 E001 0.4514866 0.0217681645 7.911743e-01   18 21650901 21650927 27 - 0.141 0.188 0.492
ENSG00000158201 E002 29.5730012 0.0255774501 4.779982e-02 1.745345e-01 18 21650928 21651096 169 - 1.372 1.565 0.664
ENSG00000158201 E003 205.7944140 0.0090348436 2.076152e-01 4.389562e-01 18 21651097 21651692 596 - 2.246 2.307 0.204
ENSG00000158201 E004 92.0015769 0.0015334802 7.416112e-01 8.614525e-01 18 21651693 21651763 71 - 1.920 1.914 -0.019
ENSG00000158201 E005 9.8777076 0.0056613440 3.571471e-01 5.933966e-01 18 21654889 21655083 195 - 0.958 1.073 0.421
ENSG00000158201 E006 149.7315007 0.0004968161 3.845897e-02 1.507633e-01 18 21656861 21657026 166 - 2.142 2.083 -0.195
ENSG00000158201 E007 97.0118508 0.0004395988 1.619512e-02 8.250996e-02 18 21657104 21657152 49 - 1.962 1.873 -0.299
ENSG00000158201 E008 71.2738450 0.0151960877 3.062078e-01 5.468795e-01 18 21659170 21659179 10 - 1.825 1.755 -0.235
ENSG00000158201 E009 142.3865223 0.0009354919 1.242479e-01 3.224499e-01 18 21659180 21659343 164 - 2.117 2.073 -0.146
ENSG00000158201 E010 11.2638922 0.0213560028 6.564430e-05 1.050897e-03 18 21663678 21663849 172 - 0.865 1.341 1.724
ENSG00000158201 E011 20.2777729 0.0130793170 7.207996e-10 4.311671e-08 18 21663850 21664117 268 - 1.042 1.617 2.014
ENSG00000158201 E012 105.1021635 0.0014029265 2.581521e-01 4.968738e-01 18 21664118 21664230 113 - 1.984 1.947 -0.123
ENSG00000158201 E013 2.1941541 0.0898890733 1.647941e-02 8.357222e-02 18 21664231 21664534 304 - 0.291 0.768 2.344
ENSG00000158201 E014 0.1723744 0.0323316677 1.681712e-01   18 21682900 21683005 106 - 0.000 0.188 12.539
ENSG00000158201 E015 0.1779838 0.0351639602 1.000000e+00   18 21683781 21683919 139 - 0.076 0.000 -9.587
ENSG00000158201 E016 78.5342222 0.0066569710 3.469663e-01 5.845116e-01 18 21683920 21683965 46 - 1.860 1.817 -0.145
ENSG00000158201 E017 2.5410390 0.0083612361 3.716520e-02 1.473545e-01 18 21701276 21702315 1040 - 0.589 0.188 -2.414
ENSG00000158201 E018 130.6836212 0.0005870094 5.842001e-01 7.598271e-01 18 21702316 21702498 183 - 2.069 2.060 -0.033
ENSG00000158201 E019 107.4189272 0.0007652082 9.577326e-01 9.807050e-01 18 21703584 21703677 94 - 1.982 1.988 0.022
ENSG00000158201 E020 95.1106118 0.0004200682 5.639267e-01 7.460579e-01 18 21703678 21703747 70 - 1.934 1.921 -0.046
ENSG00000158201 E021 0.1426347 0.0323279889 1.000000e+00   18 21703748 21703825 78 - 0.076 0.000 -9.583
ENSG00000158201 E022 89.8450516 0.0004377523 2.173769e-01 4.502726e-01 18 21704504 21704780 277 - 1.891 1.950 0.198