ENSG00000157985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409538 ENSG00000157985 HEK293_OSMI2_6hA HEK293_TMG_6hB AGAP1 protein_coding protein_coding 9.015605 10.60202 8.551594 1.086574 0.3918515 -0.3097484 0.5355795 0.6636138 0.2057537 0.09484200 0.04137033 -1.64253630 0.05773333 0.06213333 0.02373333 -0.03840000 0.09829320 0.02728569 FALSE TRUE
ENST00000428334 ENSG00000157985 HEK293_OSMI2_6hA HEK293_TMG_6hB AGAP1 protein_coding protein_coding 9.015605 10.60202 8.551594 1.086574 0.3918515 -0.3097484 2.1070277 2.2170562 2.1585749 0.16730588 0.37884757 -0.03839066 0.23512917 0.21073333 0.25130000 0.04056667 0.84915322 0.02728569 FALSE TRUE
ENST00000614409 ENSG00000157985 HEK293_OSMI2_6hA HEK293_TMG_6hB AGAP1 protein_coding protein_coding 9.015605 10.60202 8.551594 1.086574 0.3918515 -0.3097484 2.7590095 4.5393324 1.7141308 0.95997973 0.36169522 -1.39978562 0.31097500 0.42096667 0.19790000 -0.22306667 0.11081738 0.02728569 FALSE TRUE
ENST00000635100 ENSG00000157985 HEK293_OSMI2_6hA HEK293_TMG_6hB AGAP1 protein_coding nonsense_mediated_decay 9.015605 10.60202 8.551594 1.086574 0.3918515 -0.3097484 0.5010467 0.6745567 0.7510763 0.36454798 0.38984386 0.15287104 0.05833333 0.06660000 0.09186667 0.02526667 0.99740535 0.02728569 FALSE TRUE
MSTRG.20106.4 ENSG00000157985 HEK293_OSMI2_6hA HEK293_TMG_6hB AGAP1 protein_coding   9.015605 10.60202 8.551594 1.086574 0.3918515 -0.3097484 2.4455162 2.1229290 3.3434690 0.09511651 0.36796724 0.65281833 0.26131667 0.20530000 0.38863333 0.18333333 0.02728569 0.02728569 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157985 E001 0.5649788 0.0362545182 1.192740e-01   2 235494043 235494088 46 + 0.000 0.303 11.410
ENSG00000157985 E002 0.4341107 0.0244411696 2.057524e-01   2 235494089 235494106 18 + 0.000 0.246 12.965
ENSG00000157985 E003 0.4341107 0.0244411696 2.057524e-01   2 235494107 235494178 72 + 0.000 0.246 12.965
ENSG00000157985 E004 8.1172669 0.0134112139 1.692499e-01 3.895919e-01 2 235494179 235494701 523 + 0.827 1.026 0.752
ENSG00000157985 E005 37.4169855 0.0202176286 2.740982e-02 1.195290e-01 2 235494702 235494849 148 + 1.670 1.505 -0.564
ENSG00000157985 E006 0.2027342 0.0362333163 7.883028e-01   2 235524324 235524539 216 + 0.000 0.099 11.275
ENSG00000157985 E007 17.9108725 0.0019105027 4.060314e-04 4.788103e-03 2 235669604 235671057 1454 + 1.017 1.364 1.236
ENSG00000157985 E008 0.3641499 0.0316200014 6.975119e-01   2 235709177 235709177 1 + 0.149 0.099 -0.682
ENSG00000157985 E009 0.3641499 0.0316200014 6.975119e-01   2 235709178 235709178 1 + 0.149 0.099 -0.682
ENSG00000157985 E010 55.4210360 0.0098507920 6.012985e-03 3.978044e-02 2 235709179 235709237 59 + 1.832 1.677 -0.525
ENSG00000157985 E011 62.4377546 0.0077919138 3.128625e-02 1.311785e-01 2 235717557 235717633 77 + 1.855 1.750 -0.354
ENSG00000157985 E012 37.8776820 0.0050173543 2.317449e-01 4.671899e-01 2 235717634 235717644 11 + 1.613 1.560 -0.181
ENSG00000157985 E013 0.1308682 0.0308814817 7.898196e-01   2 235718381 235718392 12 + 0.000 0.098 11.322
ENSG00000157985 E014 63.9884659 0.0008300085 4.936582e-02 1.780696e-01 2 235740963 235741048 86 + 1.841 1.778 -0.211
ENSG00000157985 E015 90.6616154 0.0004997523 1.375690e-03 1.273085e-02 2 235744698 235744839 142 + 2.007 1.913 -0.315
ENSG00000157985 E016 89.3677179 0.0004485529 6.296117e-03 4.118266e-02 2 235750354 235750488 135 + 1.991 1.915 -0.257
ENSG00000157985 E017 92.9219144 0.0004327861 1.879018e-03 1.625907e-02 2 235797759 235797886 128 + 2.014 1.925 -0.297
ENSG00000157985 E018 87.3241976 0.0004292137 1.191125e-03 1.136535e-02 2 235799367 235799522 156 + 1.991 1.894 -0.325
ENSG00000157985 E019 64.5005965 0.0007645911 3.748872e-04 4.486257e-03 2 235807239 235807331 93 + 1.882 1.750 -0.446
ENSG00000157985 E020 0.1426347 0.0318458141 2.912247e-01   2 235852686 235853202 517 + 0.149 0.000 -12.806
ENSG00000157985 E021 48.6800828 0.0011632829 3.082610e-03 2.391385e-02 2 235883345 235883394 50 + 1.756 1.629 -0.432
ENSG00000157985 E022 45.1498807 0.0009590152 7.717144e-03 4.800122e-02 2 235883395 235883449 55 + 1.724 1.609 -0.388
ENSG00000157985 E023 62.1415323 0.0006291559 3.784393e-01 6.108748e-01 2 235908738 235908841 104 + 1.798 1.784 -0.046
ENSG00000157985 E024 61.9618998 0.0006886240 2.041749e-01 4.348876e-01 2 235908842 235908906 65 + 1.806 1.775 -0.106
ENSG00000157985 E025 21.5278292 0.0023166040 2.920580e-01 5.327523e-01 2 235930765 235930923 159 + 1.378 1.324 -0.189
ENSG00000157985 E026 87.2736095 0.0005156664 1.525349e-01 3.659781e-01 2 235968462 235968623 162 + 1.951 1.923 -0.096
ENSG00000157985 E027 0.2027342 0.0362333163 7.883028e-01   2 236014805 236014879 75 + 0.000 0.099 11.275
ENSG00000157985 E028 83.2142266 0.0005815541 7.286241e-01 8.533871e-01 2 236036561 236036715 155 + 1.903 1.916 0.044
ENSG00000157985 E029 0.1723744 0.0361480440 7.882982e-01   2 236040612 236040750 139 + 0.000 0.099 11.273
ENSG00000157985 E030 78.3406044 0.0043862531 1.633513e-01 3.817103e-01 2 236040751 236040841 91 + 1.910 1.866 -0.150
ENSG00000157985 E031 0.0000000       2 236045937 236046031 95 +      
ENSG00000157985 E032 128.2677541 0.0023353604 1.307814e-01 3.330089e-01 2 236049059 236049281 223 + 2.114 2.083 -0.104
ENSG00000157985 E033 0.6072928 0.0193874923 5.982214e-01   2 236049282 236049831 550 + 0.259 0.179 -0.685
ENSG00000157985 E034 112.6444473 0.0004115190 1.062518e-01 2.927666e-01 2 236120192 236120447 256 + 2.060 2.032 -0.093
ENSG00000157985 E035 1296.6993421 0.0009033118 6.232851e-21 2.043400e-18 2 236123919 236131800 7882 + 3.012 3.145 0.442