ENSG00000157881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378466 ENSG00000157881 HEK293_OSMI2_6hA HEK293_TMG_6hB PANK4 protein_coding protein_coding 36.74925 48.68371 30.16718 1.229655 1.41217 -0.6902775 18.869625 28.515547 12.710499 4.9451932 0.6064590 -1.1650993 0.4990375 0.5812333 0.4225667 -0.1586667 5.475477e-01 8.190113e-05 FALSE TRUE
ENST00000515423 ENSG00000157881 HEK293_OSMI2_6hA HEK293_TMG_6hB PANK4 protein_coding retained_intron 36.74925 48.68371 30.16718 1.229655 1.41217 -0.6902775 5.188531 5.493737 5.971665 1.3748022 1.0731773 0.1201358 0.1443458 0.1144667 0.1955667 0.0811000 4.644628e-01 8.190113e-05   FALSE
MSTRG.146.3 ENSG00000157881 HEK293_OSMI2_6hA HEK293_TMG_6hB PANK4 protein_coding   36.74925 48.68371 30.16718 1.229655 1.41217 -0.6902775 6.445485 6.681489 7.582491 0.2663554 0.2076482 0.1822461 0.1847000 0.1374667 0.2518333 0.1143667 8.190113e-05 8.190113e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157881 E001 38.6910758 0.0401788879 0.8967434148 0.950190790 1 2508537 2508657 121 - 1.545 1.582 0.126
ENSG00000157881 E002 128.0110267 0.0040470356 0.3317867003 0.570640195 1 2508658 2508794 137 - 2.111 2.067 -0.147
ENSG00000157881 E003 263.0470663 0.0003093028 0.0546149044 0.190469329 1 2508795 2509060 266 - 2.360 2.403 0.144
ENSG00000157881 E004 12.3540941 0.1126495142 0.7761892577 0.882460686 1 2509793 2509861 69 - 1.043 1.114 0.255
ENSG00000157881 E005 153.3038196 0.0005929695 0.0586235865 0.199687767 1 2509862 2509930 69 - 2.112 2.169 0.192
ENSG00000157881 E006 223.7945705 0.0006852900 0.0803223160 0.245493065 1 2510057 2510157 101 - 2.285 2.329 0.149
ENSG00000157881 E007 22.6317386 0.0841314692 0.8348666856 0.916433314 1 2510293 2510677 385 - 1.361 1.331 -0.103
ENSG00000157881 E008 190.7522696 0.0003034128 0.7989969671 0.895683981 1 2510678 2510748 71 - 2.246 2.250 0.012
ENSG00000157881 E009 109.6988145 0.0005045178 0.0433042972 0.163343825 1 2510749 2510782 34 - 1.963 2.035 0.244
ENSG00000157881 E010 163.5537248 0.0004852715 0.7984402483 0.895408621 1 2511338 2511387 50 - 2.183 2.188 0.015
ENSG00000157881 E011 174.8730467 0.0007944918 0.6745484152 0.819236469 1 2511628 2511683 56 - 2.208 2.217 0.030
ENSG00000157881 E012 6.7686332 0.0670595936 0.3658361055 0.600641803 1 2512406 2512887 482 - 0.964 0.797 -0.639
ENSG00000157881 E013 275.2101759 0.0002572142 0.4709019480 0.680757811 1 2512888 2513039 152 - 2.399 2.412 0.043
ENSG00000157881 E014 241.3731280 0.0004275202 0.0827121378 0.250118830 1 2514002 2514089 88 - 2.321 2.362 0.137
ENSG00000157881 E015 206.1066385 0.0002265131 0.0565978542 0.195072079 1 2514354 2514412 59 - 2.250 2.297 0.159
ENSG00000157881 E016 154.0012748 0.0005474326 0.4457444995 0.662573245 1 2514413 2514432 20 - 2.144 2.165 0.071
ENSG00000157881 E017 160.6581310 0.0003361660 0.6663580501 0.813934369 1 2514433 2514466 34 - 2.170 2.179 0.032
ENSG00000157881 E018 14.3302112 0.0875577677 0.0481391548 0.175322990 1 2515258 2515401 144 - 1.343 1.034 -1.101
ENSG00000157881 E019 274.5378843 0.0001818596 0.1042914121 0.289363643 1 2515562 2515717 156 - 2.383 2.417 0.113
ENSG00000157881 E020 35.4679678 0.1052501117 0.0864130843 0.257247295 1 2515718 2515937 220 - 1.689 1.430 -0.887
ENSG00000157881 E021 171.7983450 0.0003478525 0.0079640169 0.049151233 1 2518164 2518264 101 - 2.151 2.228 0.256
ENSG00000157881 E022 183.6028510 0.0008378579 0.6670588238 0.814389731 1 2518516 2518597 82 - 2.244 2.227 -0.058
ENSG00000157881 E023 166.9835097 0.0003638423 0.9144145200 0.959300068 1 2519143 2519203 61 - 2.197 2.190 -0.022
ENSG00000157881 E024 193.8136279 0.0018750951 0.4964276608 0.698517989 1 2519204 2519324 121 - 2.241 2.260 0.066
ENSG00000157881 E025 218.6897965 0.0002355686 0.1190435895 0.314308761 1 2519801 2519954 154 - 2.283 2.320 0.124
ENSG00000157881 E026 202.3351851 0.0021941482 0.4241046811 0.646610668 1 2520322 2520414 93 - 2.262 2.284 0.074
ENSG00000157881 E027 239.2916399 0.0002513195 0.3072944211 0.547900255 1 2520723 2520833 111 - 2.369 2.340 -0.097
ENSG00000157881 E028 116.4690295 0.0031762374 0.0304983853 0.128828478 1 2520834 2520839 6 - 2.104 2.007 -0.327
ENSG00000157881 E029 188.7963792 0.0003568564 0.1089319704 0.297280228 1 2520840 2520906 67 - 2.278 2.229 -0.163
ENSG00000157881 E030 160.0487656 0.0008438600 0.0775997991 0.240027515 1 2521101 2521144 44 - 2.211 2.150 -0.204
ENSG00000157881 E031 266.8907166 0.0015363872 0.0025996090 0.020959664 1 2521145 2521260 116 - 2.454 2.363 -0.303
ENSG00000157881 E032 206.0342156 0.0010746950 0.0005717323 0.006324884 1 2521261 2521315 55 - 2.351 2.245 -0.355
ENSG00000157881 E033 5.0405782 0.0735336805 0.0105261011 0.060360428 1 2521316 2521366 51 - 1.005 0.559 -1.794
ENSG00000157881 E034 7.1231773 0.0785054644 0.2688398657 0.508590951 1 2521367 2521717 351 - 0.999 0.814 -0.702
ENSG00000157881 E035 200.6327988 0.0002700698 0.0522047947 0.184853815 1 2521718 2521800 83 - 2.309 2.254 -0.186
ENSG00000157881 E036 0.5657866 0.0237610829 0.4515749401   1 2521801 2521941 141 - 0.290 0.157 -1.121
ENSG00000157881 E037 5.2386583 0.2084482956 0.5212524503 0.715740638 1 2525601 2526187 587 - 0.675 0.809 0.545
ENSG00000157881 E038 161.4192667 0.0008376212 0.8806032556 0.941563746 1 2526464 2526602 139 - 2.184 2.174 -0.032