ENSG00000157827

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288670 ENSG00000157827 HEK293_OSMI2_6hA HEK293_TMG_6hB FMNL2 protein_coding protein_coding 7.451392 4.796706 12.29526 1.117162 0.2526799 1.356155 0.9933164 0.6971006 1.501432 0.15649464 0.4753890 1.0959287 0.1145458 0.1459667 0.1223000 -0.02366667 8.767644e-01 2.703582e-05 FALSE TRUE
ENST00000475377 ENSG00000157827 HEK293_OSMI2_6hA HEK293_TMG_6hB FMNL2 protein_coding protein_coding 7.451392 4.796706 12.29526 1.117162 0.2526799 1.356155 1.1805824 1.8497515 1.063828 0.59725089 0.2553599 -0.7923463 0.2480500 0.3678000 0.0858000 -0.28200000 1.480569e-03 2.703582e-05 FALSE TRUE
MSTRG.19342.2 ENSG00000157827 HEK293_OSMI2_6hA HEK293_TMG_6hB FMNL2 protein_coding   7.451392 4.796706 12.29526 1.117162 0.2526799 1.356155 2.9157359 1.6263392 4.775495 0.39296434 0.6217412 1.5481964 0.3835750 0.3495667 0.3895333 0.03996667 9.326529e-01 2.703582e-05 FALSE TRUE
MSTRG.19342.3 ENSG00000157827 HEK293_OSMI2_6hA HEK293_TMG_6hB FMNL2 protein_coding   7.451392 4.796706 12.29526 1.117162 0.2526799 1.356155 2.3033511 0.5713688 4.866742 0.09994047 0.3055956 3.0683921 0.2408333 0.1284000 0.3954000 0.26700000 2.703582e-05 2.703582e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157827 E001 3.9576737 0.0810061319 8.491647e-01 9.244676e-01 2 152335174 152335190 17 + 0.648 0.707 0.246
ENSG00000157827 E002 23.7036993 0.0015415862 1.891521e-01 4.159058e-01 2 152335191 152335577 387 + 1.305 1.466 0.561
ENSG00000157827 E003 26.3121983 0.0130969961 3.502801e-01 5.874971e-01 2 152335578 152335720 143 + 1.402 1.383 -0.066
ENSG00000157827 E004 30.6184667 0.0169728720 3.599416e-03 2.692791e-02 2 152521943 152522026 84 + 1.515 1.301 -0.739
ENSG00000157827 E005 40.3557949 0.0124383498 1.160493e-01 3.092591e-01 2 152542739 152542819 81 + 1.594 1.538 -0.192
ENSG00000157827 E006 41.0543368 0.0165472675 2.399766e-02 1.090746e-01 2 152549021 152549097 77 + 1.620 1.491 -0.438
ENSG00000157827 E007 37.0866777 0.0033370054 3.080045e-07 1.008994e-05 2 152558740 152558823 84 + 1.613 1.305 -1.061
ENSG00000157827 E008 40.8835147 0.0045555983 2.834086e-07 9.378273e-06 2 152560883 152561035 153 + 1.654 1.346 -1.058
ENSG00000157827 E009 39.6346779 0.0096804865 1.304463e-04 1.866598e-03 2 152575136 152575244 109 + 1.631 1.391 -0.823
ENSG00000157827 E010 0.1308682 0.0326491905 2.303208e-01   2 152578621 152578887 267 + 0.000 0.177 11.376
ENSG00000157827 E011 40.0189003 0.0105930449 1.294759e-02 7.024465e-02 2 152578888 152578964 77 + 1.609 1.479 -0.446
ENSG00000157827 E012 49.9297532 0.0146196812 3.921339e-02 1.527301e-01 2 152580956 152581049 94 + 1.696 1.604 -0.312
ENSG00000157827 E013 46.0654013 0.0198927703 2.063601e-02 9.813419e-02 2 152607339 152607413 75 + 1.673 1.534 -0.474
ENSG00000157827 E014 0.1779838 0.0437926795 1.000000e+00   2 152607414 152607653 240 + 0.081 0.000 -8.829
ENSG00000157827 E015 50.9510726 0.0249978656 3.757264e-02 1.485058e-01 2 152611495 152611605 111 + 1.714 1.585 -0.438
ENSG00000157827 E016 57.2060640 0.0085122323 2.347281e-02 1.074512e-01 2 152614851 152615000 150 + 1.753 1.668 -0.287
ENSG00000157827 E017 56.0833187 0.0023696757 9.496482e-02 2.729031e-01 2 152617091 152617192 102 + 1.726 1.702 -0.079
ENSG00000157827 E018 75.2239160 0.0041438222 3.994009e-04 4.725993e-03 2 152618846 152619158 313 + 1.877 1.751 -0.424
ENSG00000157827 E019 9.3025879 0.0054998366 3.595524e-01 5.954540e-01 2 152619509 152619555 47 + 1.002 0.957 -0.166
ENSG00000157827 E020 1.7562421 0.0308373205 9.760958e-01 9.898398e-01 2 152619556 152619577 22 + 0.422 0.478 0.285
ENSG00000157827 E021 26.0415585 0.0133412912 2.315332e-01 4.669351e-01 2 152619578 152619718 141 + 1.407 1.356 -0.177
ENSG00000157827 E022 0.1614157 0.0343228887 1.000000e+00   2 152622537 152622557 21 + 0.081 0.000 -8.827
ENSG00000157827 E023 0.2922838 0.0252747441 5.871167e-01   2 152625148 152625437 290 + 0.081 0.177 1.291
ENSG00000157827 E024 54.1497125 0.0054457861 1.167581e-02 6.513226e-02 2 152625438 152625562 125 + 1.730 1.640 -0.304
ENSG00000157827 E025 89.3853546 0.0105745966 1.964808e-02 9.471690e-02 2 152626525 152626727 203 + 1.939 1.871 -0.229
ENSG00000157827 E026 103.1193230 0.0102948410 1.110823e-01 3.007467e-01 2 152628299 152628533 235 + 1.988 1.958 -0.099
ENSG00000157827 E027 60.0753897 0.0006682251 4.868994e-01 6.918258e-01 2 152629656 152629724 69 + 1.740 1.775 0.117
ENSG00000157827 E028 52.9714781 0.0085725071 4.436667e-01 6.611454e-01 2 152629825 152629905 81 + 1.687 1.703 0.056
ENSG00000157827 E029 54.2096286 0.0007829894 5.896711e-01 7.634928e-01 2 152632008 152632137 130 + 1.677 1.771 0.319
ENSG00000157827 E030 64.2006324 0.0397326415 3.212952e-01 5.608260e-01 2 152636427 152636590 164 + 1.733 1.867 0.452
ENSG00000157827 E031 54.8772459 0.8888141743 4.354715e-01 6.553493e-01 2 152637573 152637674 102 + 1.642 1.834 0.648
ENSG00000157827 E032 58.0093541 0.9025577248 4.288704e-01 6.502627e-01 2 152639958 152640056 99 + 1.663 1.863 0.676
ENSG00000157827 E033 55.7089682 0.8982420308 4.373499e-01 6.567289e-01 2 152640791 152640914 124 + 1.647 1.844 0.669
ENSG00000157827 E034 2.1873296 0.1857841423 6.496378e-01 8.032402e-01 2 152643419 152643544 126 + 0.427 0.551 0.611
ENSG00000157827 E035 31.8105859 0.2398153352 5.229294e-01 7.169939e-01 2 152645434 152645480 47 + 1.443 1.555 0.382
ENSG00000157827 E036 17.3805489 0.1097000930 7.506701e-01 8.671591e-01 2 152645481 152645609 129 + 1.212 1.275 0.222
ENSG00000157827 E037 87.2676408 1.2359236564 3.426315e-01 5.803177e-01 2 152647796 152648142 347 + 1.769 2.124 1.195
ENSG00000157827 E038 207.2536072 0.0028996760 5.570033e-10 3.396480e-08 2 152648143 152649000 858 + 2.182 2.453 0.905
ENSG00000157827 E039 164.9000884 0.0225335008 5.454460e-04 6.087268e-03 2 152649001 152650346 1346 + 2.056 2.383 1.094