ENSG00000157796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399820 ENSG00000157796 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR19 protein_coding protein_coding 7.200465 3.698925 11.81244 0.3915315 0.360961 1.672455 3.4052460 1.275602 6.0823509 0.1418342 0.1413605 2.244555 0.41377083 0.3459667 0.51513333 0.16916667 2.362655e-02 9.579198e-06 FALSE TRUE
ENST00000509560 ENSG00000157796 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR19 protein_coding protein_coding 7.200465 3.698925 11.81244 0.3915315 0.360961 1.672455 0.3274474 0.000000 0.7692989 0.0000000 0.1607385 6.284105 0.03000417 0.0000000 0.06590000 0.06590000 7.659699e-04 9.579198e-06 FALSE FALSE
ENST00000512534 ENSG00000157796 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR19 protein_coding retained_intron 7.200465 3.698925 11.81244 0.3915315 0.360961 1.672455 1.3394348 1.043062 2.1840095 0.2503717 0.1345497 1.058979 0.20533333 0.2797667 0.18460000 -0.09516667 5.370376e-01 9.579198e-06 FALSE FALSE
ENST00000512588 ENSG00000157796 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR19 protein_coding retained_intron 7.200465 3.698925 11.81244 0.3915315 0.360961 1.672455 0.8282506 1.042304 0.5093888 0.1064001 0.1222131 -1.018664 0.17479583 0.2857667 0.04356667 -0.24220000 9.579198e-06 9.579198e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157796 E001 2.0318379 0.0252430693 4.680081e-01 0.6787410927 4 39182504 39182523 20 + 0.472 0.335 -0.757
ENSG00000157796 E002 2.4891217 0.0092101310 6.090641e-02 0.2048463994 4 39182524 39182528 5 + 0.566 0.199 -2.209
ENSG00000157796 E003 2.4891217 0.0092101310 6.090641e-02 0.2048463994 4 39182529 39182530 2 + 0.566 0.199 -2.209
ENSG00000157796 E004 10.7910646 0.0071299903 1.260732e-01 0.3256206783 4 39182531 39182547 17 + 1.049 0.869 -0.674
ENSG00000157796 E005 13.9991362 0.0026470671 3.419357e-02 0.1393799881 4 39182548 39182563 16 + 1.159 0.932 -0.831
ENSG00000157796 E006 22.4354509 0.0015031309 2.378073e-01 0.4740263635 4 39185726 39185817 92 + 1.327 1.237 -0.316
ENSG00000157796 E007 21.8090171 0.0016168454 6.680113e-02 0.2178802051 4 39186539 39186604 66 + 1.327 1.174 -0.539
ENSG00000157796 E008 28.8982619 0.0013327074 9.302506e-02 0.2693433253 4 39189656 39189781 126 + 1.436 1.317 -0.414
ENSG00000157796 E009 23.6818897 0.0017906033 8.624148e-02 0.2568895373 4 39194544 39194659 116 + 1.359 1.222 -0.477
ENSG00000157796 E010 0.0000000       4 39194660 39194781 122 +      
ENSG00000157796 E011 26.4118918 0.0087748850 1.813516e-02 0.0894708962 4 39199478 39199593 116 + 1.418 1.207 -0.736
ENSG00000157796 E012 22.5603996 0.0016648905 4.124680e-01 0.6379525144 4 39203642 39203722 81 + 1.323 1.266 -0.202
ENSG00000157796 E013 0.0000000       4 39203723 39203727 5 +      
ENSG00000157796 E014 25.9533654 0.0023427765 8.894833e-01 0.9464404005 4 39205154 39205266 113 + 1.362 1.385 0.078
ENSG00000157796 E015 34.1085580 0.0011914044 2.763812e-01 0.5163747922 4 39205563 39205736 174 + 1.490 1.425 -0.226
ENSG00000157796 E016 0.0000000       4 39205737 39206115 379 +      
ENSG00000157796 E017 22.9087580 0.0016113702 2.210271e-02 0.1029384947 4 39214601 39214671 71 + 1.352 1.157 -0.685
ENSG00000157796 E018 20.1513831 0.0019997411 8.875188e-03 0.0532602504 4 39215841 39215881 41 + 1.305 1.059 -0.874
ENSG00000157796 E019 36.2349949 0.0012794618 2.351386e-02 0.1075897850 4 39215882 39216013 132 + 1.535 1.385 -0.519
ENSG00000157796 E020 35.2094344 0.0010221977 6.042853e-02 0.2037920995 4 39216096 39216210 115 + 1.517 1.395 -0.420
ENSG00000157796 E021 30.6056519 0.0043410493 2.708069e-02 0.1185350938 4 39217134 39217240 107 + 1.465 1.292 -0.600
ENSG00000157796 E022 13.6810363 0.0026146596 9.225850e-02 0.2679278234 4 39217983 39217986 4 + 1.137 0.961 -0.645
ENSG00000157796 E023 33.0986769 0.0012893920 3.627967e-01 0.5979871932 4 39217987 39218105 119 + 1.477 1.424 -0.183
ENSG00000157796 E024 4.6835378 0.0727744786 4.114972e-02 0.1577322164 4 39218106 39219133 1028 + 0.769 0.334 -2.072
ENSG00000157796 E025 30.9292215 0.0013361143 2.073349e-01 0.4386113877 4 39224884 39225033 150 + 1.456 1.374 -0.285
ENSG00000157796 E026 32.1651770 0.0013370795 4.688444e-01 0.6792867523 4 39228210 39228357 148 + 1.464 1.424 -0.139
ENSG00000157796 E027 18.2126743 0.0021583267 9.628403e-01 0.9833914094 4 39228486 39228530 45 + 1.215 1.222 0.025
ENSG00000157796 E028 17.6389025 0.0018952769 4.089096e-01 0.6351677623 4 39228531 39228554 24 + 1.224 1.157 -0.239
ENSG00000157796 E029 15.6019596 0.0025526484 1.149851e-01 0.3074554665 4 39228555 39228557 3 + 1.191 1.036 -0.556
ENSG00000157796 E030 29.4465979 0.0013855748 4.844455e-01 0.6901766996 4 39228558 39228690 133 + 1.425 1.385 -0.141
ENSG00000157796 E031 32.5385140 0.0012304256 5.235175e-01 0.7174701836 4 39231797 39231956 160 + 1.467 1.434 -0.115
ENSG00000157796 E032 21.0425963 0.0020832786 9.519520e-01 0.9779404740 4 39232162 39232189 28 + 1.273 1.279 0.022
ENSG00000157796 E033 27.3000395 0.0014646256 2.162798e-01 0.4490461508 4 39232190 39232272 83 + 1.404 1.317 -0.301
ENSG00000157796 E034 0.8048655 0.0191548908 2.136921e-01   4 39232273 39232308 36 + 0.278 0.000 -10.303
ENSG00000157796 E035 12.9789200 0.0065009233 2.352660e-02 0.1076335703 4 39234766 39234766 1 + 1.136 0.869 -0.989
ENSG00000157796 E036 26.0676571 0.0015879705 9.015065e-02 0.2640681937 4 39234767 39234875 109 + 1.395 1.266 -0.450
ENSG00000157796 E037 0.0000000       4 39237680 39237994 315 +      
ENSG00000157796 E038 21.5702573 0.0015692645 8.816109e-01 0.9421784548 4 39240277 39240334 58 + 1.281 1.305 0.084
ENSG00000157796 E039 32.2917048 0.0013928803 6.986984e-01 0.8347818993 4 39244248 39244388 141 + 1.459 1.443 -0.055
ENSG00000157796 E040 25.8494266 0.0014865903 7.141585e-01 0.8444308300 4 39244470 39244552 83 + 1.369 1.352 -0.060
ENSG00000157796 E041 26.5152034 0.0014842172 4.808412e-01 0.6876395750 4 39245369 39245452 84 + 1.359 1.424 0.225
ENSG00000157796 E042 32.3724845 0.0011539187 1.502499e-01 0.3626599916 4 39253146 39253292 147 + 1.431 1.540 0.375
ENSG00000157796 E043 30.9711293 0.0020165156 1.407582e-01 0.3486780402 4 39253906 39254030 125 + 1.464 1.363 -0.348
ENSG00000157796 E044 32.7329648 0.0048005263 2.496406e-01 0.4874637405 4 39255848 39255960 113 + 1.484 1.404 -0.275
ENSG00000157796 E045 28.2754467 0.0012935388 1.792696e-01 0.4029822714 4 39257486 39257554 69 + 1.422 1.329 -0.323
ENSG00000157796 E046 23.7599923 0.0018109102 5.314819e-01 0.7230465192 4 39266063 39266140 78 + 1.313 1.374 0.213
ENSG00000157796 E047 23.8438410 0.1089281889 7.534736e-01 0.8688112445 4 39267995 39268091 97 + 1.312 1.394 0.286
ENSG00000157796 E048 22.5822293 0.0036536646 1.588941e-01 0.3750989122 4 39269976 39270052 77 + 1.277 1.404 0.442
ENSG00000157796 E049 17.2172979 0.0024217417 5.926038e-02 0.2011266720 4 39270053 39270100 48 + 1.149 1.329 0.635
ENSG00000157796 E050 21.8705375 0.0020405435 4.701646e-01 0.6802014099 4 39272980 39273061 82 + 1.281 1.352 0.248
ENSG00000157796 E051 78.0197532 0.0214491022 3.229971e-03 0.0247808176 4 39273062 39274807 1746 + 1.752 2.010 0.869
ENSG00000157796 E052 41.1040152 0.0014117791 9.737480e-02 0.2771771123 4 39274808 39274958 151 + 1.531 1.643 0.385
ENSG00000157796 E053 2.8526514 0.0084646924 4.500960e-01 0.6657430445 4 39274959 39275339 381 + 0.567 0.438 -0.624
ENSG00000157796 E054 2.5411883 0.0083832329 7.089284e-03 0.0450273129 4 39276962 39276963 2 + 0.353 0.794 2.059
ENSG00000157796 E055 4.2936696 0.0065354654 8.356559e-03 0.0509564057 4 39276964 39277019 56 + 0.545 0.932 1.591
ENSG00000157796 E056 47.1555249 0.0009039632 1.889250e-05 0.0003641335 4 39277020 39277143 124 + 1.544 1.788 0.829
ENSG00000157796 E057 0.2922838 0.0270707493 3.979182e-01   4 39277144 39277158 15 + 0.072 0.199 1.695
ENSG00000157796 E058 38.4355115 0.0009134559 1.035006e-04 0.0015391234 4 39278131 39278207 77 + 1.459 1.702 0.830
ENSG00000157796 E059 0.3447487 0.2056415742 4.866560e-02   4 39278271 39278538 268 + 0.000 0.337 12.356
ENSG00000157796 E060 47.6159294 0.0031487047 6.675457e-05 0.0010656572 4 39278539 39278663 125 + 1.545 1.788 0.826
ENSG00000157796 E061 41.4021461 0.0010891238 4.697575e-04 0.0054007512 4 39285487 39285810 324 + 1.495 1.712 0.739