ENSG00000157741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000473989 ENSG00000157741 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN2 protein_coding protein_coding 4.013286 2.883067 6.595889 0.5337397 0.3777677 1.191153 2.7981616 2.2795718 3.9206312 0.38397963 0.15742548 0.7796832 0.73172917 0.8033667 0.5978667 -0.2055000 2.602152e-01 7.679624e-09 FALSE TRUE
ENST00000483726 ENSG00000157741 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN2 protein_coding protein_coding 4.013286 2.883067 6.595889 0.5337397 0.3777677 1.191153 0.2582137 0.1886373 0.4045846 0.05529641 0.01885343 1.0615300 0.07075417 0.0656000 0.0616000 -0.0040000 9.828782e-01 7.679624e-09 FALSE TRUE
ENST00000609762 ENSG00000157741 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN2 protein_coding retained_intron 4.013286 2.883067 6.595889 0.5337397 0.3777677 1.191153 0.1797557 0.3488594 0.0000000 0.28410135 0.00000000 -5.1653468 0.05373333 0.1090000 0.0000000 -0.1090000 2.665347e-01 7.679624e-09   FALSE
MSTRG.30797.5 ENSG00000157741 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN2 protein_coding   4.013286 2.883067 6.595889 0.5337397 0.3777677 1.191153 0.5994787 0.0000000 1.8853479 0.00000000 0.34795359 7.5663189 0.10182500 0.0000000 0.2845333 0.2845333 7.679624e-09 7.679624e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157741 E001 0.1779838 0.263234313 7.217674e-01   7 139230356 139230468 113 + 0.077 0.000 -21.902
ENSG00000157741 E002 3.1658801 0.018271285 9.155922e-02 0.2665803102 7 139231237 139231259 23 + 0.610 0.501 -0.503
ENSG00000157741 E003 13.6939096 0.015113089 3.363047e-05 0.0005949815 7 139231260 139231377 118 + 1.176 0.906 -0.991
ENSG00000157741 E004 16.2419248 0.021691465 8.623949e-03 0.0521561599 7 139231378 139231768 391 + 1.203 1.145 -0.208
ENSG00000157741 E005 10.4426615 0.073426033 8.800193e-03 0.0529392524 7 139231769 139231952 184 + 1.056 0.845 -0.794
ENSG00000157741 E006 7.6520168 0.016437964 4.080601e-03 0.0296233882 7 139237005 139237007 3 + 0.938 0.728 -0.823
ENSG00000157741 E007 19.0796870 0.082032907 5.352981e-03 0.0364556987 7 139237008 139237097 90 + 1.296 1.094 -0.717
ENSG00000157741 E008 24.6091150 0.108180121 2.746659e-03 0.0218486091 7 139251956 139252057 102 + 1.415 1.134 -0.986
ENSG00000157741 E009 16.8861235 0.135576173 2.618761e-02 0.1158834201 7 139258488 139258518 31 + 1.241 1.063 -0.637
ENSG00000157741 E010 26.9839979 0.100000516 3.664762e-02 0.1459467993 7 139258519 139258625 107 + 1.416 1.329 -0.301
ENSG00000157741 E011 28.4807011 0.054621555 2.464037e-02 0.1110890408 7 139259267 139259370 104 + 1.427 1.389 -0.132
ENSG00000157741 E012 61.2869916 0.064242237 5.898630e-03 0.0392432439 7 139261252 139261741 490 + 1.763 1.677 -0.293
ENSG00000157741 E013 22.7552731 0.027015089 4.111502e-03 0.0297916786 7 139266333 139266403 71 + 1.341 1.276 -0.225
ENSG00000157741 E014 28.6188676 0.038347585 1.386813e-02 0.0738237991 7 139269394 139269523 130 + 1.428 1.409 -0.068
ENSG00000157741 E015 30.1421382 0.028483229 8.885025e-03 0.0533017059 7 139272322 139272440 119 + 1.451 1.435 -0.054
ENSG00000157741 E016 35.1501007 0.038790410 6.536757e-03 0.0423941802 7 139273297 139273410 114 + 1.520 1.481 -0.133
ENSG00000157741 E017 37.8461494 0.061881137 5.367321e-02 0.1882864075 7 139273931 139274074 144 + 1.533 1.553 0.068
ENSG00000157741 E018 16.8878709 0.102891342 3.336725e-01 0.5722665588 7 139276097 139276147 51 + 1.175 1.271 0.338
ENSG00000157741 E019 12.9262901 0.054344500 8.533617e-01 0.9268415528 7 139276148 139277714 1567 + 1.001 1.292 1.041
ENSG00000157741 E020 15.9062277 0.084550973 6.241422e-02 0.2081777371 7 139279318 139279360 43 + 1.189 1.145 -0.160
ENSG00000157741 E021 17.3476778 0.071296569 1.684771e-01 0.3885291814 7 139282005 139282055 51 + 1.199 1.250 0.177
ENSG00000157741 E022 185.1750496 0.106952051 1.450578e-01 0.3549897243 7 139283024 139284574 1551 + 2.197 2.269 0.240
ENSG00000157741 E023 41.0581336 0.030585398 5.574767e-02 0.1930552693 7 139293232 139293463 232 + 1.554 1.629 0.258
ENSG00000157741 E024 0.1723744 0.068141128 3.198199e-01   7 139293627 139293888 262 + 0.000 0.188 24.840
ENSG00000157741 E025 23.3370535 0.001661006 5.817791e-01 0.7582461828 7 139293889 139293981 93 + 1.257 1.525 0.926
ENSG00000157741 E026 35.3087945 0.436296246 4.216622e-01 0.6448802268 7 139297787 139297964 178 + 1.415 1.695 0.956
ENSG00000157741 E027 25.3823495 0.366794669 6.036556e-01 0.7725991286 7 139297965 139298038 74 + 1.313 1.499 0.643
ENSG00000157741 E028 793.7489248 1.891093904 4.350872e-01 0.6550395922 7 139298039 139307607 9569 + 2.701 3.098 1.319
ENSG00000157741 E029 77.9371782 0.516779910 5.065594e-02 0.1812244405 7 139307608 139308236 629 + 1.525 2.231 2.380