ENSG00000157600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372068 ENSG00000157600 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM164 protein_coding protein_coding 25.21665 31.77536 18.27393 2.292563 0.3660855 -0.7977865 8.282130 9.663459 7.232058 1.0841554 0.53406323 -0.4176322 0.34456250 0.30246667 0.3957667 0.09330000 0.32421212 0.02982139 FALSE TRUE
ENST00000372072 ENSG00000157600 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM164 protein_coding protein_coding 25.21665 31.77536 18.27393 2.292563 0.3660855 -0.7977865 9.104420 11.796037 3.489394 1.3006481 0.47994286 -1.7543479 0.33255417 0.36996667 0.1916667 -0.17830000 0.02982139 0.02982139 FALSE FALSE
ENST00000372073 ENSG00000157600 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM164 protein_coding protein_coding 25.21665 31.77536 18.27393 2.292563 0.3660855 -0.7977865 2.774189 4.239672 2.852311 0.9626797 1.13094446 -0.5701712 0.11393333 0.13843333 0.1548667 0.01643333 1.00000000 0.02982139 FALSE TRUE
ENST00000497754 ENSG00000157600 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM164 protein_coding processed_transcript 25.21665 31.77536 18.27393 2.292563 0.3660855 -0.7977865 2.164103 2.175464 2.612641 1.0877343 0.07735851 0.2630808 0.09166667 0.06656667 0.1432333 0.07666667 0.76071499 0.02982139 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157600 E001 3.2003831 0.0078801757 5.352873e-01 7.257811e-01 X 110002411 110002625 215 + 0.515 0.646 0.594
ENSG00000157600 E002 1.2439501 0.0144936257 2.179714e-01   X 110002626 110002630 5 + 0.163 0.415 1.815
ENSG00000157600 E003 1.2439501 0.0144936257 2.179714e-01   X 110002631 110002634 4 + 0.163 0.415 1.815
ENSG00000157600 E004 1.2439501 0.0144936257 2.179714e-01   X 110002635 110002635 1 + 0.163 0.415 1.815
ENSG00000157600 E005 6.9859834 0.0046901678 2.627936e-02 1.161459e-01 X 110002636 110002686 51 + 0.621 0.966 1.373
ENSG00000157600 E006 25.6930405 0.0012813909 7.839012e-01 8.868818e-01 X 110002687 110002772 86 + 1.384 1.403 0.065
ENSG00000157600 E007 0.9995898 0.0259170575 3.603084e-01   X 110003054 110003060 7 + 0.374 0.227 -0.987
ENSG00000157600 E008 1.3449587 0.2031315629 4.069340e-01   X 110003061 110003062 2 + 0.447 0.288 -0.937
ENSG00000157600 E009 9.9372765 0.0035885557 8.304040e-01 9.140101e-01 X 110003063 110003094 32 + 1.004 1.017 0.047
ENSG00000157600 E010 17.3911647 0.0026302485 2.117702e-01 4.438307e-01 X 110003095 110003113 19 + 1.283 1.213 -0.245
ENSG00000157600 E011 17.5938989 0.0031250399 2.417471e-01 4.784965e-01 X 110003114 110003114 1 + 1.283 1.220 -0.222
ENSG00000157600 E012 33.6745514 0.0011389013 8.734022e-01 9.378440e-01 X 110003115 110003156 42 + 1.479 1.528 0.170
ENSG00000157600 E013 23.4256670 0.0017570120 3.574245e-01 5.936149e-01 X 110003157 110003178 22 + 1.375 1.344 -0.109
ENSG00000157600 E014 71.2644592 0.0005033355 2.704658e-03 2.159543e-02 X 110003501 110003585 85 + 1.889 1.798 -0.306
ENSG00000157600 E015 111.0762843 0.0028370815 1.316992e-02 7.112597e-02 X 110003586 110003782 197 + 2.067 2.002 -0.217
ENSG00000157600 E016 78.1387124 0.0005721666 4.691944e-03 3.296512e-02 X 110003783 110003882 100 + 1.923 1.844 -0.264
ENSG00000157600 E017 45.2629415 0.0078269407 2.256201e-01 4.600747e-01 X 110003883 110003885 3 + 1.667 1.627 -0.135
ENSG00000157600 E018 164.9498091 0.0025805064 1.671686e-03 1.482149e-02 X 110003886 110004164 279 + 2.241 2.167 -0.246
ENSG00000157600 E019 0.6783511 0.0193449847 1.710870e-01   X 110065101 110065523 423 + 0.000 0.282 10.483
ENSG00000157600 E020 97.9658403 0.0054259891 6.115088e-02 2.053555e-01 X 110067347 110067396 50 + 1.998 1.945 -0.177
ENSG00000157600 E021 107.1324877 0.0073805355 1.105596e-01 2.999101e-01 X 110109080 110109146 67 + 2.034 1.988 -0.153
ENSG00000157600 E022 102.7372870 0.0047589845 4.212350e-02 1.602316e-01 X 110144798 110144854 57 + 2.022 1.965 -0.193
ENSG00000157600 E023 76.4030625 0.0030127037 1.656422e-01 3.846819e-01 X 110144855 110144876 22 + 1.873 1.846 -0.091
ENSG00000157600 E024 144.7929043 0.0027573414 2.505999e-01 4.886233e-01 X 110171420 110171520 101 + 2.136 2.133 -0.009
ENSG00000157600 E025 221.1746398 0.0042623187 4.767805e-01 6.848488e-01 X 110173245 110173453 209 + 2.308 2.323 0.051
ENSG00000157600 E026 2559.6356014 0.0020780151 3.609182e-06 8.692697e-05 X 110173454 110177788 4335 + 3.320 3.408 0.295
ENSG00000157600 E027 9.5211089 0.1113715720 2.936089e-01 5.342785e-01 X 110182306 110182734 429 + 1.121 0.922 -0.729