ENSG00000157470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288228 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding protein_coding 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.8328556 0.5152391 1.3020606 0.10168122 0.11758251 1.32078822 0.26914167 0.20696667 0.36013333 0.15316667 3.894837e-01 2.373237e-05 FALSE TRUE
ENST00000557895 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding processed_transcript 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.1845221 0.1229938 0.1184912 0.12299383 0.11849125 -0.04968924 0.05388333 0.04850000 0.02903333 -0.01946667 9.973338e-01 2.373237e-05   FALSE
ENST00000558513 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding retained_intron 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.3772238 0.3822978 0.4234215 0.11074412 0.03902549 0.14382155 0.11856667 0.14923333 0.11873333 -0.03050000 9.121842e-01 2.373237e-05 FALSE TRUE
ENST00000558900 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding retained_intron 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.4112271 0.2011986 0.5334276 0.10406727 0.08369023 1.36348745 0.12965833 0.07383333 0.14603333 0.07220000 6.893340e-01 2.373237e-05 FALSE FALSE
ENST00000559628 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding protein_coding 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.2342130 0.3252136 0.0000000 0.05424444 0.00000000 -5.06700889 0.07342083 0.13450000 0.00000000 -0.13450000 2.373237e-05 2.373237e-05   FALSE
ENST00000560118 ENSG00000157470 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM81A protein_coding processed_transcript 3.124678 2.521835 3.66103 0.2122398 0.2754148 0.5360011 0.6515442 0.6672594 0.4553573 0.10463834 0.05923930 -0.54136945 0.21947917 0.26150000 0.12620000 -0.13530000 1.435279e-01 2.373237e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157470 E001 0.0000000       15 59372693 59372779 87 +      
ENSG00000157470 E002 0.1426347 0.030967006 0.722521176   15 59372995 59373091 97 + 0.099 0.000 -9.299
ENSG00000157470 E003 0.1426347 0.030967006 0.722521176   15 59402276 59402358 83 + 0.099 0.000 -11.824
ENSG00000157470 E004 0.9512337 0.182985521 0.006850038   15 59438186 59438200 15 + 0.000 0.535 14.195
ENSG00000157470 E005 0.9512337 0.182985521 0.006850038   15 59438201 59438204 4 + 0.000 0.535 14.195
ENSG00000157470 E006 2.4328577 0.009515762 0.111179989 0.30092471 15 59438205 59438230 26 + 0.404 0.668 1.252
ENSG00000157470 E007 2.5637258 0.008898259 0.065380624 0.21475897 15 59438231 59438244 14 + 0.404 0.704 1.403
ENSG00000157470 E008 3.0697026 0.007804681 0.011471012 0.06428544 15 59438245 59438260 16 + 0.404 0.798 1.782
ENSG00000157470 E009 3.1415686 0.008020449 0.011395585 0.06397040 15 59438261 59438282 22 + 0.404 0.799 1.784
ENSG00000157470 E010 0.0000000       15 59438464 59438495 32 +      
ENSG00000157470 E011 0.1723744 0.031775234 0.319839526   15 59438496 59438630 135 + 0.000 0.148 12.228
ENSG00000157470 E012 1.3042373 0.013043828 0.005092991   15 59439024 59439064 41 + 0.099 0.585 3.474
ENSG00000157470 E013 0.1308682 0.032649190 0.321207323   15 59439954 59439954 1 + 0.000 0.148 12.223
ENSG00000157470 E014 3.6287120 0.007924629 0.004075644 0.02959562 15 59439955 59440033 79 + 0.446 0.875 1.856
ENSG00000157470 E015 4.8397475 0.086995532 0.547392059 0.73440583 15 59440034 59440123 90 + 0.706 0.827 0.485
ENSG00000157470 E016 2.2330013 0.632115030 0.558312883 0.74206486 15 59443990 59444310 321 + 0.363 0.647 1.397
ENSG00000157470 E017 1.1957345 0.015190635 0.348342532   15 59445106 59445148 43 + 0.248 0.419 1.081
ENSG00000157470 E018 0.6482515 0.035294489 0.552437359   15 59445149 59445163 15 + 0.248 0.148 -0.926
ENSG00000157470 E019 1.2743254 0.017588370 0.913170852   15 59445164 59445208 45 + 0.358 0.346 -0.076
ENSG00000157470 E020 4.4538886 0.007165152 0.040148148 0.15508675 15 59445209 59445262 54 + 0.582 0.875 1.206
ENSG00000157470 E021 4.5660435 0.007127740 0.356020866 0.59252709 15 59445263 59445568 306 + 0.662 0.799 0.562
ENSG00000157470 E022 3.0137212 0.009594508 0.168321970 0.38832716 15 59446432 59446564 133 + 0.484 0.705 0.993
ENSG00000157470 E023 4.7717394 0.118195329 0.384213410 0.61576648 15 59446565 59446681 117 + 0.658 0.861 0.815
ENSG00000157470 E024 3.2721153 0.008461783 0.018818165 0.09181627 15 59458550 59458617 68 + 0.729 0.346 -1.837
ENSG00000157470 E025 3.0563817 0.045221182 0.125645040 0.32486933 15 59458618 59458646 29 + 0.685 0.419 -1.239
ENSG00000157470 E026 13.8762592 0.003688794 0.785124083 0.88763224 15 59459933 59460206 274 + 1.171 1.158 -0.046
ENSG00000157470 E027 6.2277467 0.005935775 0.496275011 0.69838570 15 59460207 59460640 434 + 0.804 0.899 0.365
ENSG00000157470 E028 6.5753280 0.004692267 0.034791318 0.14103985 15 59492271 59492389 119 + 0.963 0.704 -1.013
ENSG00000157470 E029 7.6744823 0.005164257 0.152814787 0.36637968 15 59507213 59507342 130 + 0.987 0.826 -0.611
ENSG00000157470 E030 12.1820392 0.003340224 0.248324819 0.48610767 15 59508863 59508969 107 + 1.148 1.048 -0.363
ENSG00000157470 E031 14.6395546 0.005555350 0.038452576 0.15075217 15 59514289 59514424 136 + 1.246 1.063 -0.654
ENSG00000157470 E032 17.3375606 0.002462272 0.033694814 0.13805956 15 59516645 59516840 196 + 1.311 1.146 -0.582
ENSG00000157470 E033 45.3801414 0.018068339 0.205314451 0.43626538 15 59521254 59523555 2302 + 1.683 1.614 -0.238