ENSG00000157214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287908 ENSG00000157214 HEK293_OSMI2_6hA HEK293_TMG_6hB STEAP2 protein_coding protein_coding 1.206166 0.6044674 2.085127 0.1572161 0.1628997 1.769629 0.38275417 0.33136177 0.81025869 0.07662849 0.14373670 1.2647775 0.31518333 0.66003333 0.39190000 -0.26813333 6.990398e-01 8.241718e-06 FALSE TRUE
ENST00000394621 ENSG00000157214 HEK293_OSMI2_6hA HEK293_TMG_6hB STEAP2 protein_coding protein_coding 1.206166 0.6044674 2.085127 0.1572161 0.1628997 1.769629 0.21259641 0.03771878 0.15715043 0.03771878 0.15715043 1.8085179 0.16879167 0.04106667 0.08783333 0.04676667 9.318583e-01 8.241718e-06 FALSE TRUE
ENST00000394622 ENSG00000157214 HEK293_OSMI2_6hA HEK293_TMG_6hB STEAP2 protein_coding protein_coding 1.206166 0.6044674 2.085127 0.1572161 0.1628997 1.769629 0.09825817 0.08306022 0.13544163 0.08306022 0.13544163 0.6442037 0.17162500 0.09046667 0.05760000 -0.03286667 9.176083e-01 8.241718e-06 FALSE TRUE
ENST00000402625 ENSG00000157214 HEK293_OSMI2_6hA HEK293_TMG_6hB STEAP2 protein_coding protein_coding 1.206166 0.6044674 2.085127 0.1572161 0.1628997 1.769629 0.19776098 0.00000000 0.78704107 0.00000000 0.10723600 6.3165822 0.09397917 0.00000000 0.37490000 0.37490000 8.241718e-06 8.241718e-06 FALSE TRUE
MSTRG.30193.11 ENSG00000157214 HEK293_OSMI2_6hA HEK293_TMG_6hB STEAP2 protein_coding   1.206166 0.6044674 2.085127 0.1572161 0.1628997 1.769629 0.11546927 0.11257195 0.05563717 0.07716414 0.05563717 -0.9010438 0.10096250 0.15470000 0.02366667 -0.13103333 4.612985e-01 8.241718e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157214 E001 0.0000000       7 90167590 90167913 324 +      
ENSG00000157214 E002 0.5668842 0.428897810 3.072219e-01   7 90211686 90211739 54 + 0.085 0.304 2.220
ENSG00000157214 E003 0.7448680 0.230247694 4.828292e-01   7 90211740 90211743 4 + 0.158 0.299 1.180
ENSG00000157214 E004 2.2089437 0.020236188 9.881829e-01 0.995912147 7 90211744 90211859 116 + 0.471 0.466 -0.022
ENSG00000157214 E005 1.4938154 0.127453342 8.775972e-01 0.940050825 7 90211860 90211872 13 + 0.365 0.387 0.126
ENSG00000157214 E006 2.4273362 0.010848931 7.082391e-01 0.840668569 7 90211873 90211930 58 + 0.530 0.465 -0.314
ENSG00000157214 E007 2.2659205 0.011467366 8.365246e-01 0.917565194 7 90211931 90211934 4 + 0.501 0.465 -0.177
ENSG00000157214 E008 3.1828732 0.008008107 5.480881e-01 0.734945945 7 90211935 90212045 111 + 0.629 0.531 -0.440
ENSG00000157214 E009 0.3088520 0.025312153 5.597403e-01   7 90212276 90212336 61 + 0.085 0.170 1.144
ENSG00000157214 E010 0.0000000       7 90213820 90213860 41 +      
ENSG00000157214 E011 1.8566305 0.011522560 2.589872e-01 0.497852550 7 90215274 90216490 1217 + 0.500 0.292 -1.173
ENSG00000157214 E012 0.4397201 0.037568404 2.193519e-01   7 90216491 90216494 4 + 0.085 0.291 2.139
ENSG00000157214 E013 1.3732410 0.015096237 9.009079e-01   7 90216495 90216603 109 + 0.362 0.387 0.143
ENSG00000157214 E014 19.7005656 0.005710934 8.203554e-04 0.008447443 7 90225050 90225574 525 + 1.368 1.062 -1.082
ENSG00000157214 E015 16.7250389 0.002276739 2.702930e-03 0.021585344 7 90226971 90227297 327 + 1.288 1.005 -1.013
ENSG00000157214 E016 11.9015609 0.002788039 1.189748e-01 0.314190559 7 90227298 90227498 201 + 1.126 0.962 -0.597
ENSG00000157214 E017 9.2465294 0.003206634 7.621241e-01 0.873912340 7 90229872 90230036 165 + 0.995 0.962 -0.123
ENSG00000157214 E018 7.6997464 0.003849060 5.397234e-01 0.728787746 7 90232337 90232484 148 + 0.934 0.860 -0.282
ENSG00000157214 E019 45.6084304 0.003092558 5.511774e-01 0.737160166 7 90232485 90234736 2252 + 1.649 1.616 -0.110
ENSG00000157214 E020 5.5610034 0.007720160 7.577333e-01 0.871246798 7 90234737 90234829 93 + 0.807 0.764 -0.173
ENSG00000157214 E021 44.4624845 0.001019396 3.462128e-03 0.026115973 7 90234830 90236890 2061 + 1.578 1.719 0.479
ENSG00000157214 E022 20.3657713 0.002124090 9.106841e-06 0.000193464 7 90236891 90237683 793 + 1.179 1.501 1.123
ENSG00000157214 E023 0.1308682 0.032649190 2.165907e-01   7 90238099 90238137 39 + 0.000 0.170 10.588