ENSG00000157181

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287859 ENSG00000157181 HEK293_OSMI2_6hA HEK293_TMG_6hB ODR4 protein_coding protein_coding 13.15565 4.060353 28.33579 0.4626989 1.414498 2.799908 5.0957254 2.01576870 10.734886 0.11740765 0.9512068 2.407109 0.44511667 0.504000000 0.37793333 -0.12606667 0.32959008 0.03187732 FALSE  
ENST00000419367 ENSG00000157181 HEK293_OSMI2_6hA HEK293_TMG_6hB ODR4 protein_coding protein_coding 13.15565 4.060353 28.33579 0.4626989 1.414498 2.799908 0.6571267 0.02882297 2.144455 0.02882297 0.4427009 5.794269 0.03110833 0.006233333 0.07606667 0.06983333 0.03187732 0.03187732 FALSE  
ENST00000478571 ENSG00000157181 HEK293_OSMI2_6hA HEK293_TMG_6hB ODR4 protein_coding processed_transcript 13.15565 4.060353 28.33579 0.4626989 1.414498 2.799908 0.7519955 0.41629792 2.105594 0.41629792 1.0539542 2.311129 0.06876250 0.094133333 0.07126667 -0.02286667 0.84974969 0.03187732 FALSE  
MSTRG.2753.1 ENSG00000157181 HEK293_OSMI2_6hA HEK293_TMG_6hB ODR4 protein_coding   13.15565 4.060353 28.33579 0.4626989 1.414498 2.799908 4.9003107 1.04061008 10.297591 0.38227530 0.2772084 3.294408 0.33397917 0.264800000 0.36493333 0.10013333 0.77571108 0.03187732 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157181 E001 2.199356 0.0971407250 5.421863e-01 0.730632023 1 186375786 186375790 5 + 0.409 0.259 -0.937
ENSG00000157181 E002 2.341991 0.0641401989 4.621472e-01 0.674613834 1 186375791 186375791 1 + 0.429 0.259 -1.049
ENSG00000157181 E003 4.826687 0.0476689956 2.503202e-01 0.488296688 1 186375792 186375818 27 + 0.664 0.418 -1.157
ENSG00000157181 E004 6.368308 0.0141817340 2.085091e-01 0.440073564 1 186375819 186375837 19 + 0.760 0.535 -0.973
ENSG00000157181 E005 33.644315 0.0151042323 3.314169e-02 0.136444724 1 186375838 186375902 65 + 1.413 1.190 -0.781
ENSG00000157181 E006 56.339588 0.0007255361 6.183017e-02 0.206949128 1 186375903 186375974 72 + 1.617 1.502 -0.394
ENSG00000157181 E007 103.858058 0.0005090842 1.627937e-01 0.380905476 1 186379767 186379884 118 + 1.872 1.818 -0.183
ENSG00000157181 E008 71.668847 0.0050156221 1.604320e-02 0.081968520 1 186383022 186383059 38 + 1.728 1.571 -0.533
ENSG00000157181 E009 109.309298 0.0022870166 2.566005e-01 0.495380882 1 186383060 186383156 97 + 1.895 1.852 -0.145
ENSG00000157181 E010 89.762469 0.0011825239 3.877980e-01 0.618759259 1 186385988 186386083 96 + 1.809 1.778 -0.104
ENSG00000157181 E011 87.870482 0.0005605422 4.014706e-01 0.629526185 1 186388442 186388548 107 + 1.796 1.767 -0.099
ENSG00000157181 E012 2.960933 0.0394496665 8.355454e-01 0.916846371 1 186389583 186389587 5 + 0.484 0.534 0.240
ENSG00000157181 E013 67.913038 0.0011524708 2.289426e-03 0.018981454 1 186389588 186389624 37 + 1.704 1.512 -0.652
ENSG00000157181 E014 138.667996 0.0025400409 1.185247e-03 0.011320069 1 186390711 186390851 141 + 2.006 1.857 -0.502
ENSG00000157181 E015 128.547299 0.0008790399 6.179032e-02 0.206852451 1 186391696 186391791 96 + 1.966 1.895 -0.237
ENSG00000157181 E016 92.813138 0.0007147518 8.849444e-01 0.943869924 1 186393947 186394015 69 + 1.816 1.838 0.077
ENSG00000157181 E017 131.653558 0.0003855732 6.509526e-01 0.804183388 1 186398313 186398419 107 + 1.963 1.998 0.117
ENSG00000157181 E018 77.938182 0.0006910375 6.027919e-01 0.772068274 1 186398420 186398441 22 + 1.739 1.784 0.151
ENSG00000157181 E019 114.959877 0.0004533670 8.255210e-01 0.911245908 1 186398954 186399043 90 + 1.911 1.917 0.020
ENSG00000157181 E020 48.414346 0.0008728411 2.330460e-01 0.468666912 1 186399044 186399044 1 + 1.551 1.479 -0.248
ENSG00000157181 E021 153.457541 0.0003789464 4.154859e-01 0.640183111 1 186406083 186406268 186 + 2.028 2.076 0.160
ENSG00000157181 E022 9.931223 0.0371733200 9.204110e-04 0.009265929 1 186411811 186411893 83 + 0.795 1.273 1.760
ENSG00000157181 E023 2.097780 0.3959817018 9.532477e-02 0.273544070 1 186417377 186417543 167 + 0.284 0.722 2.211
ENSG00000157181 E024 116.190126 0.0004463030 4.756017e-01 0.683918333 1 186417544 186417654 111 + 1.917 1.900 -0.057
ENSG00000157181 E025 86.107901 0.0005421533 8.691970e-01 0.935502619 1 186419009 186419077 69 + 1.782 1.807 0.083
ENSG00000157181 E026 208.704305 0.0002576747 1.998230e-02 0.095812464 1 186419078 186420087 1010 + 2.152 2.243 0.302
ENSG00000157181 E027 338.129389 0.0052685138 3.680918e-06 0.000088429 1 186420088 186421378 1291 + 2.343 2.522 0.599