ENSG00000157045

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287706 ENSG00000157045 HEK293_OSMI2_6hA HEK293_TMG_6hB NTAN1 protein_coding protein_coding 12.60902 10.55152 10.06933 0.4762051 0.4189013 -0.06741774 9.5366269 7.7942943 6.824804 0.9321727 0.5873005 -0.1913683 0.75281250 0.73396667 0.6792667 -0.05470000 9.008214e-01 2.113514e-06 FALSE TRUE
ENST00000568320 ENSG00000157045 HEK293_OSMI2_6hA HEK293_TMG_6hB NTAN1 protein_coding protein_coding 12.60902 10.55152 10.06933 0.4762051 0.4189013 -0.06741774 0.3361692 0.2904687 0.739259 0.2904687 0.7392590 1.3182500 0.02913333 0.02526667 0.0772000 0.05193333 1.000000e+00 2.113514e-06 FALSE FALSE
ENST00000624579 ENSG00000157045 HEK293_OSMI2_6hA HEK293_TMG_6hB NTAN1 protein_coding protein_coding 12.60902 10.55152 10.06933 0.4762051 0.4189013 -0.06741774 0.6974143 0.0000000 1.173230 0.0000000 0.3721665 6.8865870 0.05250000 0.00000000 0.1148333 0.11483333 2.113514e-06 2.113514e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000157045 E001 1.5374170 0.0329072530 0.2896019893 0.530145616 16 15037854 15037856 3 - 0.510 0.325 -1.006
ENSG00000157045 E002 2.4595312 0.0103674951 0.5459461084 0.733402374 16 15037857 15037873 17 - 0.600 0.509 -0.419
ENSG00000157045 E003 53.4871177 0.6393935908 0.4193387579 0.643155792 16 15037874 15038144 271 - 1.657 1.779 0.413
ENSG00000157045 E004 47.4012899 0.5905958161 0.4156718056 0.640305570 16 15038145 15038210 66 - 1.610 1.725 0.389
ENSG00000157045 E005 30.6316626 0.2063784308 0.5715069800 0.751370090 16 15038574 15038575 2 - 1.474 1.511 0.127
ENSG00000157045 E006 43.6789304 0.0734383573 0.4896171633 0.693733662 16 15038576 15038607 32 - 1.608 1.671 0.214
ENSG00000157045 E007 59.5501410 0.0210229176 0.3543598727 0.591156882 16 15038608 15038687 80 - 1.732 1.809 0.263
ENSG00000157045 E008 72.6134554 0.0030109611 0.9404061926 0.972491784 16 15039969 15040066 98 - 1.854 1.870 0.055
ENSG00000157045 E009 2.0879661 0.1811500640 0.3939114914 0.623450996 16 15040067 15040467 401 - 0.329 0.554 1.188
ENSG00000157045 E010 64.5845586 0.0111958812 0.4500997371 0.665743044 16 15041068 15041121 54 - 1.825 1.798 -0.092
ENSG00000157045 E011 69.7526311 0.0257302545 0.5585557246 0.742236585 16 15041623 15041676 54 - 1.855 1.832 -0.075
ENSG00000157045 E012 79.7582721 0.0034908338 0.0859308140 0.256304100 16 15044334 15044407 74 - 1.933 1.870 -0.212
ENSG00000157045 E013 14.7717781 0.0052320941 0.0001328466 0.001895673 16 15044408 15046054 1647 - 0.927 1.318 1.409
ENSG00000157045 E014 3.3385212 0.0081064506 0.8484844834 0.924076549 16 15047216 15047417 202 - 0.601 0.639 0.167
ENSG00000157045 E015 3.2314257 0.0322924732 0.2528204597 0.491024931 16 15047418 15047427 10 - 0.510 0.712 0.891
ENSG00000157045 E016 3.0944006 0.0495265889 0.3607103674 0.596202872 16 15047428 15047441 14 - 0.511 0.686 0.779
ENSG00000157045 E017 79.0317051 0.0075336918 0.1459635868 0.356323121 16 15047442 15047550 109 - 1.930 1.870 -0.203
ENSG00000157045 E018 51.1646165 0.0009717795 0.1562607407 0.371272022 16 15047855 15047920 66 - 1.741 1.683 -0.197
ENSG00000157045 E019 41.1477205 0.0103483046 0.3693581689 0.603552919 16 15047997 15048077 81 - 1.639 1.595 -0.150
ENSG00000157045 E020 22.7834257 0.0080381596 0.7880662668 0.889397523 16 15048078 15048099 22 - 1.340 1.376 0.125
ENSG00000157045 E021 0.5173834 0.1516142833 0.0570967389   16 15055741 15055890 150 - 0.329 0.000 -11.146
ENSG00000157045 E022 27.9893303 0.0032091055 0.4115647297 0.637210123 16 15055891 15056079 189 - 1.409 1.478 0.240