ENSG00000156831

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287437 ENSG00000156831 HEK293_OSMI2_6hA HEK293_TMG_6hB NSMCE2 protein_coding protein_coding 22.52475 6.224317 41.24517 0.4693536 1.115955 2.726272 10.9037118 1.8021159 20.16864423 0.2527182 0.61313753 3.477082 0.45735833 0.29976667 0.490366667 0.19060000 2.718075e-01 1.116255e-11 FALSE TRUE
ENST00000517532 ENSG00000156831 HEK293_OSMI2_6hA HEK293_TMG_6hB NSMCE2 protein_coding protein_coding 22.52475 6.224317 41.24517 0.4693536 1.115955 2.726272 2.6575714 0.0000000 7.17793233 0.0000000 1.27991729 9.489433 0.07958750 0.00000000 0.172933333 0.17293333 1.116255e-11 1.116255e-11 FALSE FALSE
ENST00000521460 ENSG00000156831 HEK293_OSMI2_6hA HEK293_TMG_6hB NSMCE2 protein_coding processed_transcript 22.52475 6.224317 41.24517 0.4693536 1.115955 2.726272 0.2748227 0.4100839 0.07132155 0.1500824 0.07132155 -2.368968 0.02837917 0.07063333 0.001733333 -0.06890000 1.109636e-02 1.116255e-11   FALSE
ENST00000522563 ENSG00000156831 HEK293_OSMI2_6hA HEK293_TMG_6hB NSMCE2 protein_coding protein_coding 22.52475 6.224317 41.24517 0.4693536 1.115955 2.726272 6.1343471 2.3112880 11.00943369 0.5526724 0.63538498 2.247053 0.28695417 0.36503333 0.266866667 -0.09816667 6.533286e-01 1.116255e-11 FALSE TRUE
MSTRG.32071.2 ENSG00000156831 HEK293_OSMI2_6hA HEK293_TMG_6hB NSMCE2 protein_coding   22.52475 6.224317 41.24517 0.4693536 1.115955 2.726272 0.8850749 1.1540625 0.11886987 0.4390568 0.11886987 -3.175182 0.07270000 0.17723333 0.002766667 -0.17446667 5.321626e-03 1.116255e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156831 E001 0.0000000       8 125091679 125091819 141 +      
ENSG00000156831 E002 0.3337900 0.0286325456 2.132968e-01   8 125091820 125091843 24 + 0.056 0.246 2.485
ENSG00000156831 E003 3.0094537 0.0082123346 5.129173e-01 7.101813e-01 8 125091844 125091859 16 + 0.484 0.608 0.577
ENSG00000156831 E004 7.9921842 0.0120868331 6.313758e-01 7.912664e-01 8 125091860 125091863 4 + 0.820 0.895 0.291
ENSG00000156831 E005 8.9396844 0.0039799991 8.828391e-01 9.427850e-01 8 125091864 125091869 6 + 0.870 0.896 0.098
ENSG00000156831 E006 17.2117522 0.0051709562 3.773831e-01 6.101632e-01 8 125091870 125091878 9 + 1.110 1.211 0.358
ENSG00000156831 E007 29.6460969 0.0108168332 1.497731e-01 3.619701e-01 8 125091879 125091900 22 + 1.326 1.464 0.479
ENSG00000156831 E008 73.0560230 0.0006007110 8.019849e-01 8.975171e-01 8 125091901 125091958 58 + 1.732 1.723 -0.029
ENSG00000156831 E009 0.8875026 0.0213007973 1.853274e-01   8 125094468 125094533 66 + 0.149 0.403 1.904
ENSG00000156831 E010 5.5433919 0.0059519147 9.291092e-01 9.665729e-01 8 125099454 125099557 104 + 0.695 0.683 -0.049
ENSG00000156831 E011 13.3926718 0.0093759182 5.249317e-01 7.184509e-01 8 125102014 125102050 37 + 1.012 1.095 0.302
ENSG00000156831 E012 85.3509276 0.0006949549 5.887453e-02 2.002092e-01 8 125102051 125102146 96 + 1.808 1.711 -0.330
ENSG00000156831 E013 76.2573590 0.0008587393 1.611136e-01 3.784763e-01 8 125102317 125102318 2 + 1.759 1.684 -0.252
ENSG00000156831 E014 104.7783107 0.0004447955 5.578556e-02 1.931432e-01 8 125102319 125102357 39 + 1.896 1.809 -0.293
ENSG00000156831 E015 147.7121320 0.0008340481 8.592629e-01 9.299695e-01 8 125102358 125102487 130 + 2.032 2.030 -0.007
ENSG00000156831 E016 0.0000000       8 125124144 125124217 74 +      
ENSG00000156831 E017 0.1614157 0.0328863034 1.000000e+00   8 125126966 125127067 102 + 0.056 0.000 -9.081
ENSG00000156831 E018 0.5339515 0.7893778693 1.000000e+00   8 125130213 125130354 142 + 0.155 0.000 -9.837
ENSG00000156831 E019 141.7954595 0.0014648353 2.419974e-01 4.787817e-01 8 125151171 125151277 107 + 2.022 1.977 -0.151
ENSG00000156831 E020 0.5339515 0.7893778693 1.000000e+00   8 125151278 125151369 92 + 0.155 0.000 -9.837
ENSG00000156831 E021 2.2605714 0.0414811298 8.994052e-01 9.515720e-01 8 125156000 125156098 99 + 0.423 0.401 -0.118
ENSG00000156831 E022 0.1614157 0.0328863034 1.000000e+00   8 125156099 125156272 174 + 0.056 0.000 -9.081
ENSG00000156831 E023 164.7748037 0.0003362287 1.624058e-01 3.803383e-01 8 125182103 125182256 154 + 2.088 2.042 -0.154
ENSG00000156831 E024 2.2408651 0.2725744755 3.927188e-01 6.225979e-01 8 125182257 125182796 540 + 0.373 0.661 1.396
ENSG00000156831 E025 153.5756622 0.0013592824 7.760410e-01 8.823875e-01 8 125357219 125357319 101 + 2.052 2.045 -0.022
ENSG00000156831 E026 161.2390733 0.0008696956 5.250802e-01 7.184985e-01 8 125357712 125357818 107 + 2.067 2.096 0.095
ENSG00000156831 E027 3.2625935 0.0080771884 2.071663e-06 5.381919e-05 8 125363026 125363321 296 + 0.320 1.038 3.183
ENSG00000156831 E028 152.3928863 0.0029275866 1.363622e-03 1.263902e-02 8 125366768 125367120 353 + 2.023 2.158 0.452