ENSG00000156804

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287396 ENSG00000156804 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO32 protein_coding retained_intron 2.816874 3.710128 1.438493 0.9608037 0.2655956 -1.360799 0.6979088 1.243382 0.3697901 0.37029947 0.18640986 -1.7225514 0.2294083 0.35743333 0.2205000 -0.1369333 7.983504e-01 4.161969e-06 FALSE TRUE
ENST00000443022 ENSG00000156804 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO32 protein_coding protein_coding 2.816874 3.710128 1.438493 0.9608037 0.2655956 -1.360799 0.2758499 0.000000 0.3577158 0.00000000 0.09836145 5.2005191 0.1349917 0.00000000 0.2630667 0.2630667 4.161969e-06 4.161969e-06 FALSE TRUE
ENST00000517956 ENSG00000156804 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO32 protein_coding protein_coding 2.816874 3.710128 1.438493 0.9608037 0.2655956 -1.360799 0.4069684 0.329692 0.3913911 0.04468672 0.03646804 0.2407814 0.1821792 0.09826667 0.3037333 0.2054667 1.537723e-01 4.161969e-06 FALSE TRUE
ENST00000520511 ENSG00000156804 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO32 protein_coding retained_intron 2.816874 3.710128 1.438493 0.9608037 0.2655956 -1.360799 1.1963549 1.513495 0.3195962 0.40377075 0.08983141 -2.2086129 0.3922750 0.41510000 0.2126667 -0.2024333 1.869502e-01 4.161969e-06 FALSE FALSE
ENST00000524000 ENSG00000156804 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO32 protein_coding retained_intron 2.816874 3.710128 1.438493 0.9608037 0.2655956 -1.360799 0.2357202 0.623560 0.0000000 0.62355999 0.00000000 -5.9854093 0.0585375 0.12916667 0.0000000 -0.1291667 9.759707e-01 4.161969e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156804 E001 43.564951 0.036808747 0.002200744 0.01841159 8 123497889 123503105 5217 - 1.805 1.492 -1.067
ENSG00000156804 E002 1.612680 0.011266273 0.029817291 0.12678489 8 123503106 123503117 12 - 0.624 0.226 -2.232
ENSG00000156804 E003 1.743548 0.010550075 0.063285706 0.21010651 8 123503118 123503126 9 - 0.624 0.281 -1.819
ENSG00000156804 E004 19.014598 0.001953780 0.228118381 0.46309498 8 123503127 123503462 336 - 1.243 1.293 0.176
ENSG00000156804 E005 15.189171 0.002856998 0.061278295 0.20566947 8 123504604 123504747 144 - 1.095 1.222 0.452
ENSG00000156804 E006 14.814198 0.003393766 0.800744048 0.89674182 8 123506392 123506574 183 - 1.182 1.159 -0.081
ENSG00000156804 E007 0.000000       8 123506575 123506625 51 -      
ENSG00000156804 E008 8.481344 0.005578606 0.515574965 0.71199945 8 123513198 123513273 76 - 0.921 0.952 0.119
ENSG00000156804 E009 11.579952 0.003245847 0.460966946 0.67383558 8 123513274 123513382 109 - 1.062 1.091 0.106
ENSG00000156804 E010 0.000000       8 123514052 123514239 188 -      
ENSG00000156804 E011 8.850009 0.003671043 0.411651948 0.63727425 8 123514240 123514333 94 - 0.944 0.993 0.184
ENSG00000156804 E012 3.701130 0.008666741 0.126242462 0.32588313 8 123526996 123527254 259 - 0.517 0.724 0.909
ENSG00000156804 E013 15.463312 0.010454747 0.279172852 0.51931661 8 123531898 123531990 93 - 1.154 1.219 0.231
ENSG00000156804 E014 0.000000       8 123531991 123532143 153 -      
ENSG00000156804 E015 9.972513 0.013654056 0.427511277 0.64911796 8 123533191 123533240 50 - 0.986 1.039 0.197
ENSG00000156804 E016 13.611005 0.004306527 0.506059401 0.70498528 8 123534702 123534814 113 - 1.126 1.145 0.068
ENSG00000156804 E017 14.626721 0.004539304 0.094616984 0.27229485 8 123540899 123541206 308 - 1.095 1.204 0.389