ENSG00000156642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351217 ENSG00000156642 HEK293_OSMI2_6hA HEK293_TMG_6hB NPTN protein_coding protein_coding 30.5464 18.0553 44.37059 0.5672307 1.315553 1.296707 26.308030 13.526199 39.278982 0.9883280 1.0703454 1.5373020 0.8406625 0.7471667 0.88536667 0.1382000 0.004290858 0.001612521 FALSE TRUE
ENST00000561898 ENSG00000156642 HEK293_OSMI2_6hA HEK293_TMG_6hB NPTN protein_coding retained_intron 30.5464 18.0553 44.37059 0.5672307 1.315553 1.296707 3.330938 4.020246 3.269498 0.4845794 0.4560541 -0.2973929 0.1317542 0.2247333 0.07346667 -0.1512667 0.001612521 0.001612521   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156642 E001 527.8409088 0.0016141474 9.635913e-02 0.2753629875 15 73560014 73560816 803 - 2.678 2.713 0.117
ENSG00000156642 E002 89.9926043 0.0052706563 1.513479e-01 0.3643061266 15 73560817 73560833 17 - 1.906 1.978 0.240
ENSG00000156642 E003 271.2856287 0.0027946311 3.981114e-01 0.6268111366 15 73560834 73560933 100 - 2.395 2.420 0.085
ENSG00000156642 E004 372.7988357 0.0002530591 1.228635e-01 0.3202616520 15 73560934 73561048 115 - 2.531 2.560 0.097
ENSG00000156642 E005 203.8485232 0.0002383823 5.232401e-02 0.1850766049 15 73561896 73561909 14 - 2.263 2.313 0.165
ENSG00000156642 E006 276.9624251 0.0002266104 4.441228e-03 0.0316090160 15 73561910 73561970 61 - 2.392 2.455 0.209
ENSG00000156642 E007 189.6878743 0.0002398433 1.135012e-01 0.3049859228 15 73563236 73563245 10 - 2.236 2.277 0.139
ENSG00000156642 E008 173.3006442 0.0002864580 9.238501e-02 0.2681668229 15 73563246 73563257 12 - 2.195 2.242 0.156
ENSG00000156642 E009 29.5945207 0.0128955677 1.850256e-05 0.0003575805 15 73563258 73563492 235 - 1.307 1.662 1.218
ENSG00000156642 E010 286.2625242 0.0011165630 8.580237e-01 0.9293191137 15 73570150 73570227 78 - 2.429 2.423 -0.020
ENSG00000156642 E011 232.8672724 0.0003236598 9.106705e-01 0.9574660564 15 73570228 73570273 46 - 2.340 2.335 -0.015
ENSG00000156642 E012 399.0984713 0.0008994350 5.150500e-01 0.7116654169 15 73570274 73570423 150 - 2.576 2.559 -0.055
ENSG00000156642 E013 404.4906834 0.0005434997 2.638919e-03 0.0212066449 15 73573662 73573795 134 - 2.593 2.527 -0.220
ENSG00000156642 E014 314.9673104 0.0007364057 2.412479e-02 0.1094503035 15 73587524 73587618 95 - 2.482 2.424 -0.192
ENSG00000156642 E015 0.6847684 0.0187099413 8.276828e-01   15 73591636 73591965 330 - 0.215 0.172 -0.396
ENSG00000156642 E016 216.5155903 0.0003206480 1.552936e-03 0.0139847370 15 73591966 73592007 42 - 2.328 2.240 -0.294
ENSG00000156642 E017 251.3884299 0.0040329954 2.152953e-02 0.1010672652 15 73592008 73592069 62 - 2.395 2.301 -0.314
ENSG00000156642 E018 242.1424604 0.0049479860 1.554165e-01 0.3700661173 15 73592070 73592137 68 - 2.370 2.307 -0.213
ENSG00000156642 E019 7.2120849 0.0239789853 7.619132e-01 0.8737789642 15 73597022 73597369 348 - 0.859 0.897 0.145
ENSG00000156642 E020 0.0000000       15 73599489 73599586 98 -      
ENSG00000156642 E021 0.1779838 0.0345525563 1.000000e+00   15 73632602 73632670 69 - 0.084 0.000 -8.205
ENSG00000156642 E022 0.1779838 0.0345525563 1.000000e+00   15 73632671 73632805 135 - 0.084 0.000 -8.205
ENSG00000156642 E023 188.9606452 0.0050517862 9.974625e-01 1.0000000000 15 73633125 73634134 1010 - 2.246 2.240 -0.018