ENSG00000156504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298090 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding protein_coding 28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 4.6691022 4.843512 2.616256 1.8281120 0.4595520 -0.8860215 0.16526667 0.16610000 0.09400000 -0.07210000 7.644493e-01 2.566392e-11 FALSE TRUE
ENST00000343004 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding protein_coding 28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 5.1434909 6.802000 3.701860 0.8122936 0.1936513 -0.8759362 0.18566250 0.25086667 0.13010000 -0.12076667 1.044674e-03 2.566392e-11 FALSE TRUE
ENST00000370790 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding protein_coding 28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 7.6964448 6.974713 8.395690 0.3922121 0.4268791 0.2671654 0.27675417 0.26300000 0.29326667 0.03026667 8.494326e-01 2.566392e-11 FALSE TRUE
ENST00000465128 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding processed_transcript 28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 1.2346834 0.000000 1.684393 0.0000000 1.6843931 7.4046248 0.04079167 0.00000000 0.05276667 0.05276667 8.929953e-01 2.566392e-11 FALSE TRUE
ENST00000486347 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding protein_coding 28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 2.9655222 3.936484 1.897794 1.3546697 0.2922721 -1.0486624 0.10467500 0.13626667 0.06540000 -0.07086667 5.400379e-01 2.566392e-11 FALSE TRUE
MSTRG.34922.17 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding   28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 1.7991031 1.866282 2.923975 0.5191505 0.4888995 0.6449798 0.06555833 0.07536667 0.10393333 0.02856667 7.960414e-01 2.566392e-11 FALSE TRUE
MSTRG.34922.4 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding   28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 2.1599637 1.432948 3.236731 0.4658224 1.0917758 1.1699686 0.07677917 0.05890000 0.11103333 0.05213333 6.811506e-01 2.566392e-11 FALSE TRUE
MSTRG.34922.7 ENSG00000156504 HEK293_OSMI2_6hA HEK293_TMG_6hB PABIR2 protein_coding   28.06967 27.15091 28.67908 3.109559 1.829167 0.07897 0.9962038 0.000000 2.828804 0.0000000 0.5461359 8.1491396 0.03497500 0.00000000 0.10153333 0.10153333 2.566392e-11 2.566392e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156504 E001 0.4644705 0.0229276373 0.198137515   X 134769566 134769566 1 - 0.000 0.266 9.792
ENSG00000156504 E002 174.1812356 0.8787900249 0.271885029 0.51175221 X 134769567 134769965 399 - 2.025 2.349 1.085
ENSG00000156504 E003 198.4124331 0.9982379755 0.379002433 0.61140609 X 134769966 134770138 173 - 2.151 2.378 0.760
ENSG00000156504 E004 247.7071221 1.0818181688 0.387683750 0.61864087 X 134770139 134770443 305 - 2.242 2.476 0.779
ENSG00000156504 E005 168.1133282 0.9659383381 0.439468924 0.65828273 X 134770444 134770583 140 - 2.122 2.286 0.548
ENSG00000156504 E006 113.0024621 0.5774720563 0.340609198 0.57857740 X 134770584 134770633 50 - 1.942 2.119 0.594
ENSG00000156504 E007 300.9375076 1.2125770821 0.495381503 0.69771655 X 134770634 134770991 358 - 2.387 2.531 0.478
ENSG00000156504 E008 149.4758590 0.9149835519 0.427334296 0.64896529 X 134770992 134771095 104 - 2.069 2.237 0.560
ENSG00000156504 E009 222.0234446 1.0761309435 0.444973437 0.66212837 X 134771096 134771354 259 - 2.237 2.409 0.572
ENSG00000156504 E010 94.8153951 0.4854446645 0.263607066 0.50288750 X 134771355 134771442 88 - 1.834 2.060 0.760
ENSG00000156504 E011 105.7444631 0.5785897797 0.398705291 0.62724010 X 134771443 134771573 131 - 1.943 2.075 0.443
ENSG00000156504 E012 184.6062834 0.9856625553 0.411073953 0.63689854 X 134771574 134771896 323 - 2.141 2.337 0.656
ENSG00000156504 E013 168.9492244 0.9533294842 0.413078912 0.63843228 X 134771897 134772028 132 - 2.110 2.296 0.622
ENSG00000156504 E014 103.7875753 0.5605089410 0.367897604 0.60234348 X 134772029 134772078 50 - 1.922 2.075 0.512
ENSG00000156504 E015 72.2315670 0.4606379659 0.424992520 0.64724666 X 134772079 134772100 22 - 1.796 1.903 0.360
ENSG00000156504 E016 104.2739066 0.5891805568 0.429794685 0.65087991 X 134772101 134772142 42 - 1.954 2.060 0.358
ENSG00000156504 E017 156.7791276 0.9629985129 0.483549424 0.68947487 X 134772143 134772283 141 - 2.118 2.242 0.415
ENSG00000156504 E018 162.0001622 0.0004608898 0.005347614 0.03643232 X 134781821 134781917 97 - 2.214 2.211 -0.008
ENSG00000156504 E019 162.4183291 0.0440742006 0.095981625 0.27470486 X 134785886 134785947 62 - 2.234 2.189 -0.149
ENSG00000156504 E020 67.2423515 0.0402818372 0.090569732 0.26482134 X 134785948 134785950 3 - 1.863 1.804 -0.200
ENSG00000156504 E021 178.0474974 0.0721916021 0.158114750 0.37395523 X 134787472 134787533 62 - 2.277 2.225 -0.174
ENSG00000156504 E022 210.8340227 0.0753727704 0.164643425 0.38355818 X 134788730 134788831 102 - 2.349 2.299 -0.165
ENSG00000156504 E023 168.5309514 0.0727428535 0.183871249 0.40894782 X 134789085 134789139 55 - 2.248 2.206 -0.139
ENSG00000156504 E024 158.6466511 0.0852562679 0.138645229 0.34545459 X 134789223 134789266 44 - 2.241 2.164 -0.259
ENSG00000156504 E025 82.5417852 0.0763632571 0.143960431 0.35332243 X 134789580 134789636 57 - 1.958 1.884 -0.250
ENSG00000156504 E026 17.8290444 0.0773452422 0.131249293 0.33377482 X 134793803 134793814 12 - 1.329 1.220 -0.385
ENSG00000156504 E027 171.3103149 0.0858783149 0.184967616 0.41046631 X 134793815 134793893 79 - 2.263 2.207 -0.187
ENSG00000156504 E028 143.3261024 0.0842689192 0.239240543 0.47569397 X 134796108 134796211 104 - 2.174 2.139 -0.115
ENSG00000156504 E029 75.3378771 0.0795652734 0.501142498 0.70160842 X 134796212 134796355 144 - 1.857 1.892 0.118
ENSG00000156504 E030 157.0506903 0.0069397927 0.642190974 0.79829300 X 134796356 134797120 765 - 2.158 2.225 0.224
ENSG00000156504 E031 65.5692879 0.0524329942 0.067378531 0.21918485 X 134797121 134797232 112 - 1.869 1.777 -0.311