ENSG00000156299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286827 ENSG00000156299 HEK293_OSMI2_6hA HEK293_TMG_6hB TIAM1 protein_coding protein_coding 12.08439 11.80377 9.431309 1.674611 0.3088123 -0.3234109 2.6352824 1.2995289 1.8765699 0.50424075 0.39149046 0.5267177 0.2057125 0.11346667 0.20143333 0.08796667 0.62815145 0.03277558 FALSE TRUE
ENST00000491927 ENSG00000156299 HEK293_OSMI2_6hA HEK293_TMG_6hB TIAM1 protein_coding retained_intron 12.08439 11.80377 9.431309 1.674611 0.3088123 -0.3234109 1.1517252 1.2825195 1.0582850 0.05350922 0.08109054 -0.2748895 0.0970750 0.11283333 0.11193333 -0.00090000 1.00000000 0.03277558 FALSE FALSE
ENST00000541036 ENSG00000156299 HEK293_OSMI2_6hA HEK293_TMG_6hB TIAM1 protein_coding protein_coding 12.08439 11.80377 9.431309 1.674611 0.3088123 -0.3234109 3.5345627 3.9465164 4.3204943 0.28956537 0.27675800 0.1303010 0.3069917 0.34306667 0.45723333 0.11416667 0.36892735 0.03277558 FALSE TRUE
ENST00000636887 ENSG00000156299 HEK293_OSMI2_6hA HEK293_TMG_6hB TIAM1 protein_coding protein_coding 12.08439 11.80377 9.431309 1.674611 0.3088123 -0.3234109 2.5506310 4.0455743 0.1739154 1.31969648 0.17391539 -4.4627921 0.2127250 0.32400000 0.01876667 -0.30523333 0.03277558 0.03277558 FALSE TRUE
MSTRG.21214.6 ENSG00000156299 HEK293_OSMI2_6hA HEK293_TMG_6hB TIAM1 protein_coding   12.08439 11.80377 9.431309 1.674611 0.3088123 -0.3234109 0.8957532 0.4221279 0.8407010 0.21538641 0.35957361 0.9771937 0.0717250 0.04263333 0.08690000 0.04426667 0.66571369 0.03277558 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156299 E001 0.1426347 0.0312193935 3.670163e-01   21 31118416 31118417 2 - 0.138 0.000 -10.182
ENSG00000156299 E002 10.2049249 0.0418316729 7.453188e-01 8.638920e-01 21 31118418 31118457 40 - 1.002 1.052 0.183
ENSG00000156299 E003 88.4453110 0.0005048700 1.331550e-04 1.899595e-03 21 31118458 31118670 213 - 1.843 1.999 0.524
ENSG00000156299 E004 98.4196892 0.0005146889 1.749256e-07 6.126293e-06 21 31118671 31118821 151 - 1.859 2.062 0.682
ENSG00000156299 E005 478.0212527 0.0061140091 3.452715e-03 2.606002e-02 21 31118822 31120356 1535 - 2.602 2.720 0.392
ENSG00000156299 E006 51.9056998 0.0092498954 6.897783e-02 2.227254e-01 21 31120357 31120379 23 - 1.637 1.765 0.432
ENSG00000156299 E007 49.5368489 0.0079254966 1.204270e-01 3.165292e-01 21 31120380 31120396 17 - 1.631 1.738 0.363
ENSG00000156299 E008 63.7587811 0.0044669071 6.854144e-02 2.218192e-01 21 31120397 31120449 53 - 1.738 1.842 0.354
ENSG00000156299 E009 65.9534588 0.0008149235 3.444524e-02 1.400772e-01 21 31120450 31120513 64 - 1.756 1.857 0.341
ENSG00000156299 E010 40.7166885 0.0010205633 1.179965e-01 3.125647e-01 21 31120514 31120514 1 - 1.557 1.651 0.320
ENSG00000156299 E011 81.3573925 0.0005884829 1.169252e-02 6.519976e-02 21 31120515 31120642 128 - 1.841 1.949 0.363
ENSG00000156299 E012 76.0298868 0.0005639240 2.107169e-02 9.958593e-02 21 31120643 31120837 195 - 1.817 1.919 0.343
ENSG00000156299 E013 22.2304822 0.0015356105 8.970180e-01 9.503116e-01 21 31123939 31124521 583 - 1.348 1.362 0.050
ENSG00000156299 E014 72.7965089 0.0006451802 5.526203e-02 1.919360e-01 21 31124522 31124694 173 - 1.809 1.896 0.293
ENSG00000156299 E015 46.8687094 0.0008424134 8.712929e-02 2.585003e-01 21 31127065 31127152 88 - 1.616 1.712 0.324
ENSG00000156299 E016 55.8275134 0.0013833656 4.788531e-02 1.747395e-01 21 31130213 31130315 103 - 1.681 1.786 0.354
ENSG00000156299 E017 41.2545325 0.0069814705 1.283989e-01 3.293054e-01 21 31130890 31130948 59 - 1.548 1.658 0.375
ENSG00000156299 E018 66.1397334 0.0017303896 2.397645e-01 4.763806e-01 21 31135933 31136041 109 - 1.783 1.844 0.204
ENSG00000156299 E019 80.9810401 0.0004684907 4.202060e-01 6.437808e-01 21 31141118 31141236 119 - 1.922 1.895 -0.090
ENSG00000156299 E020 96.1010885 0.0004394607 1.198870e-01 3.156761e-01 21 31141325 31141504 180 - 2.008 1.957 -0.172
ENSG00000156299 E021 71.4340445 0.0006142341 1.256480e-01 3.248722e-01 21 31146895 31147003 109 - 1.887 1.828 -0.199
ENSG00000156299 E022 66.6016883 0.0035012601 4.380261e-01 6.572411e-01 21 31152636 31152761 126 - 1.843 1.810 -0.109
ENSG00000156299 E023 45.1404597 0.0144274432 5.245962e-01 7.182008e-01 21 31153066 31153134 69 - 1.685 1.642 -0.146
ENSG00000156299 E024 71.2052637 0.0008779410 2.410808e-01 4.777859e-01 21 31154247 31154424 178 - 1.879 1.834 -0.152
ENSG00000156299 E025 27.7832127 0.0064271616 3.997452e-01 6.280501e-01 21 31154425 31154426 2 - 1.480 1.422 -0.199
ENSG00000156299 E026 0.0000000       21 31160445 31160909 465 -      
ENSG00000156299 E027 51.5094252 0.0063051645 6.370333e-02 2.110433e-01 21 31164962 31165065 104 - 1.769 1.661 -0.365
ENSG00000156299 E028 65.4692687 0.0013038395 2.174721e-01 4.503606e-01 21 31182421 31182645 225 - 1.844 1.793 -0.172
ENSG00000156299 E029 42.7787680 0.0137885228 5.563740e-01 7.407575e-01 21 31187001 31187087 87 - 1.661 1.621 -0.136
ENSG00000156299 E030 52.7328114 0.0100259109 7.365299e-01 8.582858e-01 21 31195224 31195305 82 - 1.735 1.718 -0.058
ENSG00000156299 E031 58.4848015 0.0019252941 8.562935e-01 9.284163e-01 21 31202908 31203012 105 - 1.773 1.769 -0.013
ENSG00000156299 E032 63.1532869 0.0006017189 6.800799e-01 8.227594e-01 21 31210045 31210215 171 - 1.804 1.791 -0.045
ENSG00000156299 E033 0.5283420 0.3046275436 4.935851e-01   21 31212631 31213397 767 - 0.246 0.108 -1.438
ENSG00000156299 E034 40.8132322 0.0042355526 1.910800e-01 4.182752e-01 21 31213398 31213472 75 - 1.654 1.581 -0.250
ENSG00000156299 E035 58.8363328 0.0006540097 1.423240e-02 7.526483e-02 21 31217553 31217699 147 - 1.827 1.719 -0.365
ENSG00000156299 E036 72.6094956 0.0006795917 4.615012e-03 3.255436e-02 21 31223406 31223591 186 - 1.922 1.808 -0.383
ENSG00000156299 E037 78.9284500 0.0068203197 6.060342e-02 2.041913e-01 21 31225726 31225950 225 - 1.952 1.854 -0.328
ENSG00000156299 E038 64.0520511 0.0006946567 3.166086e-01 5.565928e-01 21 31245488 31245660 173 - 1.827 1.787 -0.134
ENSG00000156299 E039 106.6133738 0.0014511722 3.942471e-05 6.797180e-04 21 31251742 31252189 448 - 2.107 1.958 -0.501
ENSG00000156299 E040 174.0269959 0.0040867578 5.192223e-09 2.601826e-07 21 31266010 31266983 974 - 2.354 2.131 -0.746
ENSG00000156299 E041 6.5903659 0.1578728686 1.990275e-01 4.285191e-01 21 31268411 31268695 285 - 1.027 0.719 -1.184
ENSG00000156299 E042 28.0633746 0.0117007853 6.547004e-04 7.049403e-03 21 31276732 31276908 177 - 1.602 1.327 -0.947
ENSG00000156299 E043 36.1471423 0.0011799851 1.558152e-05 3.081519e-04 21 31339243 31339422 180 - 1.692 1.443 -0.848
ENSG00000156299 E044 1.0649365 0.0770031459 4.899886e-01   21 31344138 31344261 124 - 0.395 0.264 -0.828
ENSG00000156299 E045 2.6078774 0.0085487104 6.918394e-01 8.302435e-01 21 31461224 31461319 96 - 0.510 0.579 0.317
ENSG00000156299 E046 12.3375135 0.0039978471 8.095865e-01 9.019169e-01 21 31463916 31463982 67 - 1.124 1.105 -0.069
ENSG00000156299 E047 16.5312427 0.0020707501 2.731575e-01 5.130044e-01 21 31463983 31464035 53 - 1.285 1.198 -0.307
ENSG00000156299 E048 13.8490425 0.0024777862 3.115719e-01 5.519667e-01 21 31558927 31559159 233 - 1.099 1.198 0.354
ENSG00000156299 E049 0.6787990 0.0428155220 1.938608e-02   21 31559919 31559977 59 - 0.398 0.000 -12.194