ENSG00000156232

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286760 ENSG00000156232 HEK293_OSMI2_6hA HEK293_TMG_6hB WHAMM protein_coding protein_coding 5.578337 6.568978 6.221201 1.667905 0.05283614 -0.07835302 1.3065583 2.0954735 0.2546298 0.7770937 0.2546298 -2.9920972 0.2467292 0.32596667 0.04100000 -0.28496667 0.138269896 0.005891625 FALSE TRUE
ENST00000560964 ENSG00000156232 HEK293_OSMI2_6hA HEK293_TMG_6hB WHAMM protein_coding retained_intron 5.578337 6.568978 6.221201 1.667905 0.05283614 -0.07835302 0.7298745 0.2837785 1.7391592 0.1472682 0.2161912 2.5738608 0.1298167 0.03433333 0.28013333 0.24580000 0.005891625 0.005891625 FALSE TRUE
MSTRG.11397.1 ENSG00000156232 HEK293_OSMI2_6hA HEK293_TMG_6hB WHAMM protein_coding   5.578337 6.568978 6.221201 1.667905 0.05283614 -0.07835302 0.6075142 0.1577944 0.4672358 0.1577944 0.4672358 1.5080082 0.1236667 0.04836667 0.07526667 0.02690000 1.000000000 0.005891625 FALSE TRUE
MSTRG.11397.2 ENSG00000156232 HEK293_OSMI2_6hA HEK293_TMG_6hB WHAMM protein_coding   5.578337 6.568978 6.221201 1.667905 0.05283614 -0.07835302 2.3299197 3.2472538 2.6811814 1.1070650 0.5056121 -0.2754165 0.3957083 0.48313333 0.43003333 -0.05310000 0.925361476 0.005891625 FALSE TRUE
MSTRG.11397.3 ENSG00000156232 HEK293_OSMI2_6hA HEK293_TMG_6hB WHAMM protein_coding   5.578337 6.568978 6.221201 1.667905 0.05283614 -0.07835302 0.6044707 0.7846773 1.0789952 0.3013012 0.2886743 0.4545566 0.1040875 0.10820000 0.17353333 0.06533333 0.770281438 0.005891625 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156232 E001 0.3150090 0.0377321530 7.650630e-01   15 82801850 82801877 28 + 0.144 0.102 -0.565
ENSG00000156232 E002 0.2852693 0.3236626425 1.797817e-01   15 82801878 82801931 54 + 0.248 0.000 -9.689
ENSG00000156232 E003 2.3882151 0.0092338214 2.832192e-01 5.236657e-01 15 82809489 82809627 139 + 0.617 0.455 -0.762
ENSG00000156232 E004 39.6212633 0.0154164313 6.584307e-02 2.158206e-01 15 82809628 82810335 708 + 1.491 1.667 0.603
ENSG00000156232 E005 53.4629597 0.0027192252 1.562259e-01 3.712437e-01 15 82813103 82813276 174 + 1.757 1.701 -0.189
ENSG00000156232 E006 70.4131410 0.0006249016 6.093734e-03 4.018235e-02 15 82816692 82816842 151 + 1.901 1.803 -0.329
ENSG00000156232 E007 63.8737536 0.0006346552 3.749147e-03 2.773892e-02 15 82817920 82818089 170 + 1.867 1.757 -0.372
ENSG00000156232 E008 57.7177913 0.0009866804 5.186960e-04 5.844769e-03 15 82819323 82819488 166 + 1.841 1.696 -0.490
ENSG00000156232 E009 11.9623419 0.0031874739 1.786506e-03 1.560728e-02 15 82821711 82821839 129 + 1.252 0.965 -1.039
ENSG00000156232 E010 82.6861138 0.0005797502 1.597201e-01 3.763793e-01 15 82823100 82823287 188 + 1.940 1.902 -0.125
ENSG00000156232 E011 1.2505550 0.0131934646 1.932444e-01   15 82826388 82826409 22 + 0.472 0.254 -1.306
ENSG00000156232 E012 58.6277148 0.0008504669 5.393439e-01 7.285244e-01 15 82826410 82826496 87 + 1.777 1.765 -0.042
ENSG00000156232 E013 64.6387882 0.0007540016 7.761811e-01 8.824607e-01 15 82826751 82826846 96 + 1.810 1.813 0.010
ENSG00000156232 E014 110.6288788 0.0005247301 8.900160e-01 9.466811e-01 15 82830599 82831079 481 + 2.036 2.048 0.039
ENSG00000156232 E015 351.3835047 0.0015943505 7.378818e-08 2.827729e-06 15 82833229 82836178 2950 + 2.458 2.582 0.413