ENSG00000156162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414645 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding protein_coding 10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 4.12379736 0.69564419 8.4774940 0.12214655 0.4882579 3.588326 0.34648333 0.5712667 0.45670000 -0.11456667 0.6794264847 0.0001002471 FALSE TRUE
ENST00000520774 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding nonsense_mediated_decay 10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 1.32904956 0.00000000 1.5517904 0.00000000 0.7852694 7.287057 0.06585833 0.0000000 0.08096667 0.08096667 0.6812671523 0.0001002471   FALSE
ENST00000521525 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding protein_coding 10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 0.36527838 0.18728598 0.4717768 0.12153382 0.1893565 1.288076 0.07822500 0.1345333 0.02626667 -0.10826667 0.3337611250 0.0001002471   FALSE
ENST00000522669 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding nonsense_mediated_decay 10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 0.09983681 0.00000000 0.0000000 0.00000000 0.0000000 0.000000 0.05657083 0.0000000 0.00000000 0.00000000   0.0001002471 FALSE FALSE
MSTRG.31833.1 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding   10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 1.09370751 0.00000000 2.7731696 0.00000000 0.3031326 8.120585 0.05809167 0.0000000 0.15033333 0.15033333 0.0001002471 0.0001002471 FALSE TRUE
MSTRG.31833.10 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding   10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 1.17617753 0.13354136 0.9329346 0.13354136 0.4665973 2.715691 0.17315833 0.1196000 0.05040000 -0.06920000 0.9692395244 0.0001002471 FALSE TRUE
MSTRG.31833.12 ENSG00000156162 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L4 protein_coding   10.46733 1.224121 18.53885 0.1569181 0.7247413 3.909774 0.09683458 0.07557329 0.3756459 0.07557329 0.1712571 2.172044 0.01808333 0.0739000 0.01963333 -0.05426667 1.0000000000 0.0001002471 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000156162 E001 0.0000000       8 94719703 94719833 131 +      
ENSG00000156162 E002 0.0000000       8 94719834 94719853 20 +      
ENSG00000156162 E003 0.0000000       8 94719854 94719874 21 +      
ENSG00000156162 E004 0.1779838 0.0337689104 0.528521424   8 94719875 94719877 3 + 0.038 0.000 -12.219
ENSG00000156162 E005 0.1779838 0.0337689104 0.528521424   8 94719878 94719878 1 + 0.038 0.000 -12.208
ENSG00000156162 E006 0.4632531 0.0250773388 1.000000000   8 94719879 94719882 4 + 0.104 0.000 -13.790
ENSG00000156162 E007 0.4632531 0.0250773388 1.000000000   8 94719883 94719884 2 + 0.104 0.000 -13.790
ENSG00000156162 E008 1.4085405 0.0264435728 0.537189036 0.72711157 8 94719885 94719891 7 + 0.259 0.000 -15.374
ENSG00000156162 E009 3.4758610 0.1374680680 0.172223799 0.39348790 8 94719892 94719899 8 + 0.468 0.000 -16.625
ENSG00000156162 E010 28.7467394 0.0013645998 0.173056944 0.39456333 8 94719900 94720014 115 + 1.212 1.097 -0.412
ENSG00000156162 E011 2.1204758 0.1460259138 0.366242308 0.60091503 8 94720102 94720236 135 + 0.340 0.000 -15.919
ENSG00000156162 E012 42.0861109 0.0091829199 0.488866438 0.69320880 8 94726331 94726395 65 + 1.362 1.337 -0.086
ENSG00000156162 E013 30.9951545 0.0306255211 0.759533527 0.87228321 8 94726396 94726401 6 + 1.235 1.233 -0.005
ENSG00000156162 E014 41.6351761 0.0043076412 0.337191807 0.57558198 8 94726402 94726441 40 + 1.359 1.313 -0.162
ENSG00000156162 E015 43.0609857 0.0029705383 0.542812604 0.73108149 8 94734630 94734754 125 + 1.362 1.473 0.382
ENSG00000156162 E016 47.6195215 0.0010280729 0.136824351 0.34262891 8 94738369 94738459 91 + 1.400 1.577 0.610
ENSG00000156162 E017 51.6917869 0.0011866154 0.227885911 0.46284263 8 94739413 94739519 107 + 1.437 1.590 0.524
ENSG00000156162 E018 28.9476545 0.0038280874 0.404181604 0.63168858 8 94739520 94739534 15 + 1.215 1.170 -0.160
ENSG00000156162 E019 23.5302925 0.0032075768 0.700842537 0.83619055 8 94739645 94739649 5 + 1.128 1.134 0.024
ENSG00000156162 E020 65.6414825 0.0054969721 0.730465329 0.85450234 8 94739650 94739790 141 + 1.548 1.576 0.095
ENSG00000156162 E021 3.6437258 0.0463958114 0.020225791 0.09667064 8 94744343 94744484 142 + 0.405 0.895 2.150
ENSG00000156162 E022 14.1788965 0.1129513084 0.044975141 0.16754000 8 94744485 94745084 600 + 0.874 1.323 1.629
ENSG00000156162 E023 57.1696748 0.0011561064 0.268054521 0.50770858 8 94756036 94756159 124 + 1.496 1.456 -0.136
ENSG00000156162 E024 21.8262643 0.0016609274 0.902175484 0.95295939 8 94761700 94761701 2 + 1.097 1.135 0.137
ENSG00000156162 E025 53.2469211 0.0066147353 0.281494711 0.52181239 8 94761702 94761834 133 + 1.468 1.419 -0.169
ENSG00000156162 E026 52.0898775 0.0012306050 0.060414856 0.20375426 8 94765183 94765314 132 + 1.460 1.337 -0.429
ENSG00000156162 E027 50.6275970 0.0008509607 0.085215915 0.25501179 8 94765711 94765809 99 + 1.445 1.337 -0.377
ENSG00000156162 E028 45.1731318 0.0079109137 0.006685828 0.04312711 8 94766612 94766685 74 + 1.406 1.135 -0.954
ENSG00000156162 E029 65.4841788 0.0010107919 0.007908276 0.04889530 8 94768395 94768553 159 + 1.559 1.380 -0.615
ENSG00000156162 E030 55.1703089 0.0007494436 0.595718129 0.76756529 8 94770452 94770571 120 + 1.478 1.490 0.040
ENSG00000156162 E031 29.3189092 0.0012908579 0.638111762 0.79581250 8 94777666 94777677 12 + 1.207 1.313 0.370
ENSG00000156162 E032 59.4084612 0.0006660811 0.972660969 0.98825678 8 94777678 94777786 109 + 1.505 1.564 0.202
ENSG00000156162 E033 54.1329510 0.0009705792 0.807065488 0.90035462 8 94780359 94780415 57 + 1.470 1.505 0.122
ENSG00000156162 E034 63.3434313 0.0008394496 0.365622248 0.60044375 8 94781084 94781166 83 + 1.538 1.521 -0.057
ENSG00000156162 E035 67.5805277 0.0005469922 0.039175101 0.15262292 8 94783670 94783802 133 + 1.571 1.456 -0.392
ENSG00000156162 E036 80.5702948 0.0007244319 0.020378899 0.09723823 8 94787894 94788052 159 + 1.643 1.521 -0.415
ENSG00000156162 E037 426.1978406 0.0289176131 0.013872876 0.07383982 8 94789746 94793836 4091 + 2.333 2.537 0.680