ENSG00000155816

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319653 ENSG00000155816 HEK293_OSMI2_6hA HEK293_TMG_6hB FMN2 protein_coding protein_coding 3.079529 4.676126 2.680993 1.049664 0.1000331 -0.800257 1.9817944 2.88120285 1.6420416 0.3800234 0.1397287 -0.8074198 0.67049167 0.65990000 0.61796667 -0.04193333 0.9546515532 0.0005076855 FALSE TRUE
ENST00000545751 ENSG00000155816 HEK293_OSMI2_6hA HEK293_TMG_6hB FMN2 protein_coding protein_coding 3.079529 4.676126 2.680993 1.049664 0.1000331 -0.800257 0.6240140 1.52019831 0.0000000 0.7104976 0.0000000 -7.2575748 0.17118750 0.27973333 0.00000000 -0.27973333 0.0005076855 0.0005076855 FALSE TRUE
ENST00000679980 ENSG00000155816 HEK293_OSMI2_6hA HEK293_TMG_6hB FMN2 protein_coding protein_coding 3.079529 4.676126 2.680993 1.049664 0.1000331 -0.800257 0.1070581 0.00000000 0.6880221 0.0000000 0.3555733 6.1252008 0.03906667 0.00000000 0.24726667 0.24726667 0.2347671660 0.0005076855 FALSE TRUE
ENST00000681824 ENSG00000155816 HEK293_OSMI2_6hA HEK293_TMG_6hB FMN2 protein_coding protein_coding 3.079529 4.676126 2.680993 1.049664 0.1000331 -0.800257 0.1077830 0.05121589 0.1964504 0.0291085 0.1964504 1.7538171 0.03699167 0.01236667 0.07916667 0.06680000 1.0000000000 0.0005076855 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155816 E001 0.0000000       1 240014348 240014435 88 +      
ENSG00000155816 E002 0.0000000       1 240068028 240068073 46 +      
ENSG00000155816 E003 138.7023311 1.129386635 0.3171328768 0.5571453632 1 240091883 240093724 1842 + 1.874 2.218 1.155
ENSG00000155816 E004 0.0000000       1 240123127 240123132 6 +      
ENSG00000155816 E005 0.0000000       1 240123133 240123178 46 +      
ENSG00000155816 E006 5.8139036 0.012813961 0.1817675461 0.4063170156 1 240123179 240123181 3 + 0.649 0.888 0.959
ENSG00000155816 E007 18.0316529 0.056942107 0.8095157058 0.9018794452 1 240123182 240123345 164 + 1.266 1.262 -0.015
ENSG00000155816 E008 19.4453522 0.355710768 0.6907624851 0.8295490273 1 240177921 240178068 148 + 1.264 1.310 0.160
ENSG00000155816 E009 0.0000000       1 240180169 240180180 12 +      
ENSG00000155816 E010 13.9176545 0.002535776 0.9729846695 0.9884645405 1 240188207 240188262 56 + 1.132 1.181 0.175
ENSG00000155816 E011 10.8626825 0.003290443 0.5522067787 0.7378371623 1 240206799 240206803 5 + 1.073 1.063 -0.035
ENSG00000155816 E012 28.8550782 0.001331728 0.9747797587 0.9892849764 1 240206804 240206992 189 + 1.424 1.475 0.175
ENSG00000155816 E013 54.1064286 0.001348292 0.1333196448 0.3370048656 1 240206993 240208500 1508 + 1.741 1.721 -0.068
ENSG00000155816 E014 10.6694841 0.003025210 0.5550384907 0.7398088173 1 240208501 240208576 76 + 1.056 1.045 -0.041
ENSG00000155816 E015 20.3417632 0.004823047 0.0832438164 0.2512670519 1 240208577 240208732 156 + 1.371 1.284 -0.306
ENSG00000155816 E016 26.4295445 0.022687474 0.0128103253 0.0696735802 1 240211091 240211235 145 + 1.533 1.345 -0.650
ENSG00000155816 E017 0.0000000       1 240235771 240235895 125 +      
ENSG00000155816 E018 2.9819382 0.008929851 0.2723702485 0.5122347264 1 240239639 240241160 1522 + 0.437 0.663 1.054
ENSG00000155816 E019 0.0000000       1 240245260 240245565 306 +      
ENSG00000155816 E020 0.0000000       1 240257501 240257827 327 +      
ENSG00000155816 E021 14.6892298 0.017599111 0.0000416558 0.0007122546 1 240257945 240257952 8 + 1.381 1.004 -1.343
ENSG00000155816 E022 18.6196772 0.032508372 0.0002967253 0.0036970491 1 240257953 240257994 42 + 1.474 1.116 -1.255
ENSG00000155816 E023 16.0637878 0.007772428 0.0006516699 0.0070224510 1 240257995 240258032 38 + 1.364 1.105 -0.913
ENSG00000155816 E024 0.0000000       1 240285231 240285523 293 +      
ENSG00000155816 E025 20.1795987 0.002300712 0.0770914415 0.2389730554 1 240294822 240294883 62 + 1.363 1.279 -0.294
ENSG00000155816 E026 26.1264795 0.001624270 0.4249729466 0.6472466637 1 240329076 240329167 92 + 1.424 1.422 -0.005
ENSG00000155816 E027 31.5632876 0.001299100 0.0840175550 0.2528283169 1 240329339 240329468 130 + 1.536 1.481 -0.186
ENSG00000155816 E028 35.6494886 0.005308185 0.0769942654 0.2387851481 1 240330603 240330749 147 + 1.588 1.523 -0.222
ENSG00000155816 E029 0.1779838 0.036248475 0.2423904828   1 240332116 240333886 1771 + 0.156 0.000 -12.146
ENSG00000155816 E030 18.5369323 0.001875487 0.5829636976 0.7589961565 1 240333887 240333946 60 + 1.208 1.306 0.345
ENSG00000155816 E031 26.0796336 0.001636575 0.0656732523 0.2154388202 1 240334109 240334229 121 + 1.283 1.472 0.656
ENSG00000155816 E032 0.0000000       1 240340551 240341384 834 +      
ENSG00000155816 E033 0.2027342 0.035873808 1.0000000000   1 240341385 240344781 3397 + 0.000 0.094 10.419
ENSG00000155816 E034 25.3125251 0.004076922 0.0325469369 0.1348292202 1 240355816 240355908 93 + 1.242 1.467 0.785
ENSG00000155816 E035 0.5363366 0.032768792 0.2641033878   1 240357630 240357702 73 + 0.000 0.236 12.004
ENSG00000155816 E036 0.0000000       1 240371362 240371664 303 +      
ENSG00000155816 E037 22.6087794 0.011999010 0.3285271263 0.5675234797 1 240392511 240392562 52 + 1.254 1.394 0.489
ENSG00000155816 E038 34.8513476 0.024264331 0.3715813979 0.6052703704 1 240438061 240438210 150 + 1.434 1.576 0.487
ENSG00000155816 E039 0.3751086 0.029951214 0.4684974008   1 240445012 240445193 182 + 0.000 0.171 11.420
ENSG00000155816 E040 0.1723744 0.042294602 1.0000000000   1 240457493 240459443 1951 + 0.000 0.094 10.417
ENSG00000155816 E041 0.1723744 0.042294602 1.0000000000   1 240471654 240472097 444 + 0.000 0.094 10.417
ENSG00000155816 E042 0.1723744 0.042294602 1.0000000000   1 240472098 240472126 29 + 0.000 0.094 10.417
ENSG00000155816 E043 0.1723744 0.042294602 1.0000000000   1 240472127 240472371 245 + 0.000 0.094 10.417
ENSG00000155816 E044 29.5377973 0.001492307 0.7566567464 0.8706102418 1 240472372 240472453 82 + 1.417 1.492 0.259
ENSG00000155816 E045 103.1519709 0.024712028 0.9183170406 0.9613601876 1 240474128 240475187 1060 + 1.948 2.021 0.243