ENSG00000155744

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418596 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding protein_coding 3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 1.6007916 0.38147988 3.3714881 0.04028973 0.04118051 3.110648 0.48733333 0.72780000 0.47426667 -0.25353333 0.524184418 0.004421477 FALSE TRUE
ENST00000446678 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding protein_coding 3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 0.0740234 0.05615093 0.0000000 0.05615093 0.00000000 -2.725762 0.05866250 0.06616667 0.00000000 -0.06616667 0.311402206 0.004421477   FALSE
ENST00000452799 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding protein_coding 3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 0.1035710 0.00000000 0.5367905 0.00000000 0.28435410 5.772916 0.01344167 0.00000000 0.06996667 0.06996667 0.389478776 0.004421477 FALSE FALSE
ENST00000681958 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding protein_coding 3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 0.5906798 0.08204661 1.1352290 0.05488635 0.14797314 3.637128 0.15172083 0.11180000 0.15716667 0.04536667 0.956295262 0.004421477 FALSE TRUE
MSTRG.19748.4 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding   3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 0.9182311 0.00000000 1.5125303 0.00000000 0.32159058 7.250327 0.14689583 0.00000000 0.20716667 0.20716667 0.004421477 0.004421477 FALSE TRUE
MSTRG.19748.5 ENSG00000155744 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126B protein_coding   3.679135 0.578038 7.189492 0.1419499 0.5275486 3.613914 0.1514260 0.04176185 0.1766783 0.04176185 0.09103373 1.850593 0.05893333 0.04920000 0.02653333 -0.02266667 0.942930940 0.004421477 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155744 E001 289.7164232 0.0127936417 0.041223017 0.15791759 2 200973718 200978492 4775 - 2.225 2.353 0.428
ENSG00000155744 E002 93.8916966 0.0005521377 0.006247062 0.04094064 2 200978493 200980454 1962 - 1.767 1.648 -0.402
ENSG00000155744 E003 104.9956816 0.0010171570 0.001055555 0.01033482 2 200980455 200981620 1166 - 1.815 1.667 -0.498
ENSG00000155744 E004 34.7758331 0.0015159586 0.504920851 0.70427155 2 200981621 200981871 251 - 1.335 1.318 -0.061
ENSG00000155744 E005 6.1663455 0.0051819525 0.979409853 0.99150126 2 200987365 200987532 168 - 0.661 0.695 0.143
ENSG00000155744 E006 28.1809032 0.0015787255 0.759862296 0.87246663 2 200988262 200988421 160 - 1.241 1.318 0.268
ENSG00000155744 E007 21.3229419 0.0019927688 0.612987379 0.77894775 2 200992281 200992368 88 - 1.125 1.226 0.360
ENSG00000155744 E008 20.1882392 0.0020899259 0.640579072 0.79728724 2 200992887 200993003 117 - 1.121 1.109 -0.041
ENSG00000155744 E009 0.3040503 0.0274424043 1.000000000   2 200996050 200997444 1395 - 0.083 0.000 -9.822
ENSG00000155744 E010 19.3815064 0.0611640594 0.488535857 0.69301398 2 200997445 200997540 96 - 1.089 1.220 0.471
ENSG00000155744 E011 17.3008784 0.3901136280 0.497502167 0.69918411 2 201008973 201009088 116 - 1.041 1.154 0.407
ENSG00000155744 E012 0.1614157 0.0330921149 0.664803495   2 201009089 201009452 364 - 0.043 0.000 -8.792
ENSG00000155744 E013 17.0746272 0.1491815144 0.607515760 0.77523006 2 201011392 201011472 81 - 1.041 1.135 0.339
ENSG00000155744 E014 15.9036516 0.0243535456 0.032568479 0.13487969 2 201016991 201017061 71 - 1.047 0.696 -1.357
ENSG00000155744 E015 15.6938128 0.0021677989 0.411125591 0.63690887 2 201017062 201017126 65 - 1.020 0.950 -0.260
ENSG00000155744 E016 14.6304690 0.0028878439 0.184503626 0.40982821 2 201017127 201017170 44 - 0.998 0.841 -0.593
ENSG00000155744 E017 1.2729203 0.0138491595 0.896038614   2 201021448 201021875 428 - 0.240 0.298 0.422
ENSG00000155744 E018 1.5228404 0.0131223506 1.000000000 1.00000000 2 201022059 201022114 56 - 0.289 0.298 0.062
ENSG00000155744 E019 0.4632531 0.0300840222 1.000000000   2 201022481 201022545 65 - 0.119 0.000 -10.366
ENSG00000155744 E020 0.3206185 0.0274424043 1.000000000   2 201022546 201022830 285 - 0.083 0.000 -9.823
ENSG00000155744 E021 18.3644821 0.0038637726 0.503920633 0.70352360 2 201022831 201022932 102 - 1.078 1.037 -0.150
ENSG00000155744 E022 0.6622309 0.1438786768 1.000000000   2 201023616 201023958 343 - 0.154 0.000 -9.943
ENSG00000155744 E023 14.4244426 0.0048315222 0.296245669 0.53679888 2 201023959 201024039 81 - 0.964 1.141 0.644
ENSG00000155744 E024 10.9008618 0.0441018744 0.083556662 0.25188669 2 201045496 201045593 98 - 0.838 1.163 1.203
ENSG00000155744 E025 0.5657866 0.0204203889 0.048374724   2 201052173 201052269 97 - 0.083 0.473 3.228
ENSG00000155744 E026 0.3040503 0.0274424043 1.000000000   2 201061307 201061424 118 - 0.083 0.000 -9.822
ENSG00000155744 E027 1.8940751 0.2927356154 0.383859718 0.61547083 2 201071454 201071488 35 - 0.306 0.583 1.468
ENSG00000155744 E028 2.0664494 0.1416400123 0.113282699 0.30461575 2 201071489 201071609 121 - 0.308 0.688 1.905
ENSG00000155744 E029 4.1452644 0.4600670727 0.250797522 0.48882906 2 201071610 201071671 62 - 0.502 0.821 1.368