ENSG00000155506

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518297 ENSG00000155506 HEK293_OSMI2_6hA HEK293_TMG_6hB LARP1 protein_coding protein_coding 102.3781 140.2045 77.1474 12.85008 1.505213 -0.8617587 24.248514 30.740185 18.1161262 4.019411 0.8162571 -0.7625244 0.25436250 0.21853333 0.23496667 0.01643333 0.904102961 0.009886235 FALSE TRUE
ENST00000524187 ENSG00000155506 HEK293_OSMI2_6hA HEK293_TMG_6hB LARP1 protein_coding retained_intron 102.3781 140.2045 77.1474 12.85008 1.505213 -0.8617587 27.393262 45.796865 0.5851128 8.603441 0.5851128 -6.2662569 0.21907917 0.32036667 0.00730000 -0.31306667 0.009886235 0.009886235 FALSE TRUE
ENST00000685946 ENSG00000155506 HEK293_OSMI2_6hA HEK293_TMG_6hB LARP1 protein_coding protein_coding 102.3781 140.2045 77.1474 12.85008 1.505213 -0.8617587 2.685627 2.663333 6.2645789 2.198828 2.9973833 1.2308788 0.03059167 0.02256667 0.08263333 0.06006667 0.575017063 0.009886235 FALSE TRUE
ENST00000687700 ENSG00000155506 HEK293_OSMI2_6hA HEK293_TMG_6hB LARP1 protein_coding protein_coding 102.3781 140.2045 77.1474 12.85008 1.505213 -0.8617587 30.126066 37.107250 28.8406183 1.325862 0.8229866 -0.3634876 0.30883750 0.26843333 0.37370000 0.10526667 0.100199507 0.009886235 FALSE TRUE
ENST00000690816 ENSG00000155506 HEK293_OSMI2_6hA HEK293_TMG_6hB LARP1 protein_coding protein_coding 102.3781 140.2045 77.1474 12.85008 1.505213 -0.8617587 7.839266 14.952656 10.7532674 3.329030 4.1071724 -0.4752502 0.07645000 0.10380000 0.13823333 0.03443333 0.975980683 0.009886235 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155506 E001 2.189835e+00 0.0095468968 3.119049e-01 5.522802e-01 5 154682986 154683037 52 + 0.354 0.570 1.108
ENSG00000155506 E002 0.000000e+00       5 154712843 154713130 288 +      
ENSG00000155506 E003 1.346364e+00 0.0143204355 5.823473e-01   5 154754574 154754758 185 + 0.265 0.396 0.824
ENSG00000155506 E004 2.362304e+02 0.0059195499 9.759248e-03 5.708290e-02 5 154755377 154755984 608 + 2.240 2.416 0.588
ENSG00000155506 E005 1.835319e+01 0.0359013183 2.425657e-03 1.985408e-02 5 154755985 154756002 18 + 0.935 1.396 1.650
ENSG00000155506 E006 1.752080e+02 0.0036647943 3.142607e-01 5.544972e-01 5 154756003 154756173 171 + 2.223 2.238 0.053
ENSG00000155506 E007 1.588398e+02 0.0016205414 3.457423e-04 4.195875e-03 5 154756174 154756193 20 + 2.232 2.165 -0.222
ENSG00000155506 E008 7.087110e-01 0.0193874923 1.390146e-01   5 154756411 154756522 112 + 0.000 0.299 17.567
ENSG00000155506 E009 4.093423e+00 0.0068092407 5.210963e-01 7.156290e-01 5 154757174 154757290 117 + 0.596 0.737 0.600
ENSG00000155506 E010 5.227326e-01 0.3461845953 1.000000e+00   5 154757300 154757482 183 + 0.154 0.177 0.241
ENSG00000155506 E011 1.723744e-01 0.0337973868 9.186864e-01   5 154786477 154786684 208 + 0.000 0.096 15.248
ENSG00000155506 E012 2.699700e+02 0.0025595857 2.537222e-06 6.423354e-05 5 154790325 154790386 62 + 2.478 2.381 -0.323
ENSG00000155506 E013 3.681684e+02 0.0061929487 1.892216e-07 6.563353e-06 5 154790645 154790710 66 + 2.649 2.484 -0.551
ENSG00000155506 E014 0.000000e+00       5 154791946 154792013 68 +      
ENSG00000155506 E015 5.324077e+02 0.0039047099 1.068476e-09 6.201357e-08 5 154792622 154792732 111 + 2.801 2.649 -0.506
ENSG00000155506 E016 4.133142e+02 0.0044182435 8.583645e-06 1.837978e-04 5 154792733 154792773 41 + 2.667 2.558 -0.365
ENSG00000155506 E017 3.223555e+02 0.0001782472 1.055731e-12 1.076155e-10 5 154792774 154792796 23 + 2.550 2.459 -0.304
ENSG00000155506 E018 4.880665e+02 0.0001381252 6.829903e-20 1.982692e-17 5 154793595 154793723 129 + 2.734 2.636 -0.326
ENSG00000155506 E019 3.151217e+02 0.0002218505 2.254252e-04 2.951837e-03 5 154793800 154793901 102 + 2.500 2.477 -0.075
ENSG00000155506 E020 1.797187e+02 0.0002989765 9.280967e-03 5.501523e-02 5 154793902 154793922 21 + 2.254 2.237 -0.054
ENSG00000155506 E021 2.437314e+02 0.0010457935 3.137237e-01 5.539612e-01 5 154793923 154794000 78 + 2.357 2.386 0.097
ENSG00000155506 E022 1.503538e+01 0.0029103313 3.844965e-05 6.663572e-04 5 154794046 154794099 54 + 1.359 1.048 -1.106
ENSG00000155506 E023 4.617655e+02 0.0001943582 5.638057e-18 1.299714e-15 5 154794100 154794209 110 + 2.709 2.612 -0.323
ENSG00000155506 E024 4.269670e+02 0.0018368798 2.689573e-10 1.740005e-08 5 154794210 154794262 53 + 2.684 2.568 -0.386
ENSG00000155506 E025 6.006759e+02 0.0017098694 5.008845e-08 1.998133e-06 5 154795175 154795319 145 + 2.811 2.731 -0.266
ENSG00000155506 E026 1.779838e-01 0.0341954357 2.555095e-01   5 154797410 154797418 9 + 0.153 0.000 -16.521
ENSG00000155506 E027 4.117931e+00 0.1006074707 9.040031e-01 9.539014e-01 5 154797419 154799590 2172 + 0.645 0.702 0.239
ENSG00000155506 E028 6.621885e+02 0.0010721102 6.138073e-07 1.856431e-05 5 154799591 154799759 169 + 2.836 2.786 -0.167
ENSG00000155506 E029 3.644892e+02 0.0003514041 8.079287e-08 3.068088e-06 5 154799873 154799899 27 + 2.582 2.526 -0.184
ENSG00000155506 E030 6.976298e+02 0.0001128910 1.518133e-07 5.392470e-06 5 154799900 154800042 143 + 2.841 2.822 -0.064
ENSG00000155506 E031 9.545843e+02 0.0001025190 4.107910e-10 2.560064e-08 5 154802007 154802349 343 + 2.978 2.956 -0.071
ENSG00000155506 E032 3.651421e+02 0.0002145296 7.838450e-02 2.415528e-01 5 154802350 154802399 50 + 2.533 2.554 0.069
ENSG00000155506 E033 1.283193e+01 0.1811862307 3.373262e-01 5.757036e-01 5 154802400 154803289 890 + 1.169 1.099 -0.251
ENSG00000155506 E034 5.529129e+02 0.0008426278 3.571751e-01 5.934155e-01 5 154803290 154803413 124 + 2.704 2.741 0.121
ENSG00000155506 E035 9.947159e+02 0.0008823228 3.172545e-02 1.324065e-01 5 154803540 154803745 206 + 2.972 2.988 0.054
ENSG00000155506 E036 4.523057e+02 0.0002970456 1.420731e-03 1.304785e-02 5 154804201 154804220 20 + 2.643 2.639 -0.013
ENSG00000155506 E037 6.808854e+02 0.0004490442 4.267682e-01 6.485754e-01 5 154804221 154804307 87 + 2.790 2.832 0.140
ENSG00000155506 E038 4.804636e+00 0.0706357816 2.478028e-01 4.856172e-01 5 154804774 154804860 87 + 0.839 0.694 -0.585
ENSG00000155506 E039 1.065251e+01 0.0795472524 1.945391e-01 4.227626e-01 5 154804861 154805240 380 + 1.139 0.987 -0.555
ENSG00000155506 E040 5.498611e+00 0.1247445307 6.070627e-01 7.749292e-01 5 154805754 154805880 127 + 0.810 0.785 -0.097
ENSG00000155506 E041 8.569649e+02 0.0001639552 6.493150e-01 8.030165e-01 5 154805881 154806032 152 + 2.885 2.935 0.167
ENSG00000155506 E042 8.545976e+02 0.0001169595 4.402480e-01 6.589051e-01 5 154808459 154808603 145 + 2.886 2.932 0.154
ENSG00000155506 E043 6.935604e+02 0.0001777575 7.075765e-02 2.262356e-01 5 154811247 154811356 110 + 2.770 2.854 0.280
ENSG00000155506 E044 1.666362e+00 0.0115291764 7.852824e-01 8.876961e-01 5 154811388 154811512 125 + 0.354 0.437 0.459
ENSG00000155506 E045 7.292656e+02 0.0021576785 3.358264e-02 1.377096e-01 5 154811513 154811640 128 + 2.773 2.885 0.372
ENSG00000155506 E046 1.003917e+04 0.0014845695 1.845026e-19 4.997254e-17 5 154813887 154817605 3719 + 3.874 4.038 0.545