ENSG00000155393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299192 ENSG00000155393 HEK293_OSMI2_6hA HEK293_TMG_6hB HEATR3 protein_coding protein_coding 12.99565 5.168062 19.42559 0.3329752 1.487272 1.908217 8.4711093 3.2704693 10.446078 0.3953552 1.4542140 1.672368 0.62342917 0.62840000 0.5391000 -0.08930000 7.661228e-01 2.324714e-09 FALSE TRUE
ENST00000561525 ENSG00000155393 HEK293_OSMI2_6hA HEK293_TMG_6hB HEATR3 protein_coding retained_intron 12.99565 5.168062 19.42559 0.3329752 1.487272 1.908217 0.7860921 0.1828678 2.353949 0.1828678 0.5845490 3.615515 0.04365833 0.04056667 0.1180000 0.07743333 3.819812e-01 2.324714e-09 FALSE TRUE
MSTRG.12612.13 ENSG00000155393 HEK293_OSMI2_6hA HEK293_TMG_6hB HEATR3 protein_coding   12.99565 5.168062 19.42559 0.3329752 1.487272 1.908217 1.3436037 0.9111023 2.564617 0.2399110 0.8365768 1.482925 0.12542917 0.17313333 0.1286000 -0.04453333 8.245483e-01 2.324714e-09 FALSE TRUE
MSTRG.12612.3 ENSG00000155393 HEK293_OSMI2_6hA HEK293_TMG_6hB HEATR3 protein_coding   12.99565 5.168062 19.42559 0.3329752 1.487272 1.908217 0.9474664 0.0000000 2.818135 0.0000000 0.3248009 8.143707 0.07336667 0.00000000 0.1477667 0.14776667 2.324714e-09 2.324714e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155393 E001 1.1149873 0.5286856186 0.288086066   16 50065967 50065969 3 + 0.139 0.533 2.684
ENSG00000155393 E002 5.6907738 0.1577325335 0.079940105 0.24470805 16 50065970 50065989 20 + 0.658 1.001 1.346
ENSG00000155393 E003 7.3231126 0.2299595077 0.246600492 0.48429641 16 50065990 50065995 6 + 0.803 1.024 0.838
ENSG00000155393 E004 9.9110618 0.2991549865 0.206152891 0.43720817 16 50065996 50066005 10 + 0.908 1.160 0.926
ENSG00000155393 E005 33.0622082 0.7206455350 0.319888955 0.55958490 16 50066006 50066104 99 + 1.403 1.640 0.813
ENSG00000155393 E006 36.6633666 0.4082159221 0.248493980 0.48629640 16 50066105 50066245 141 + 1.451 1.678 0.777
ENSG00000155393 E007 7.6888966 0.1095621711 0.409585904 0.63574725 16 50066246 50066269 24 + 0.852 1.007 0.581
ENSG00000155393 E008 0.8973638 0.0178853004 0.230991606   16 50066270 50066366 97 + 0.196 0.422 1.525
ENSG00000155393 E009 4.7280294 0.0893289131 0.058923612 0.20033604 16 50066367 50066391 25 + 0.585 0.976 1.572
ENSG00000155393 E010 4.0305668 0.0244480703 0.002851369 0.02250859 16 50066392 50066397 6 + 0.490 0.961 1.960
ENSG00000155393 E011 6.2785484 0.0967441739 0.008704896 0.05250361 16 50066398 50066422 25 + 0.610 1.138 2.052
ENSG00000155393 E012 28.5219971 0.0181024195 0.527786290 0.72047145 16 50066423 50066539 117 + 1.393 1.475 0.282
ENSG00000155393 E013 3.8826465 0.1338364872 0.189195437 0.41596513 16 50066540 50066772 233 + 0.543 0.821 1.174
ENSG00000155393 E014 9.8663694 0.0636094667 0.270267463 0.51023144 16 50066773 50066982 210 + 0.926 1.117 0.705
ENSG00000155393 E015 2.3563074 0.1487157513 0.165056127 0.38403178 16 50067549 50067711 163 + 0.370 0.690 1.534
ENSG00000155393 E016 64.7784153 0.0061780367 0.140306272 0.34796696 16 50068780 50068867 88 + 1.781 1.710 -0.240
ENSG00000155393 E017 1.4736294 0.0563702195 0.276261670 0.51626621 16 50069245 50069289 45 + 0.402 0.190 -1.474
ENSG00000155393 E018 80.3073733 0.0051711206 0.064361303 0.21247677 16 50070178 50070242 65 + 1.875 1.791 -0.284
ENSG00000155393 E019 85.3328987 0.0040974564 0.003907418 0.02864021 16 50070243 50070290 48 + 1.913 1.779 -0.452
ENSG00000155393 E020 99.2190644 0.0083658233 0.005376263 0.03657319 16 50072605 50072714 110 + 1.979 1.835 -0.483
ENSG00000155393 E021 0.5117739 0.0228689497 0.786075417   16 50075468 50075570 103 + 0.140 0.190 0.526
ENSG00000155393 E022 119.3585984 0.0115203253 0.034990629 0.14156217 16 50075571 50075711 141 + 2.050 1.942 -0.360
ENSG00000155393 E023 0.5775531 0.0196329369 1.000000000   16 50077902 50078019 118 + 0.196 0.189 -0.058
ENSG00000155393 E024 0.4161375 0.1059315603 0.785646526   16 50078020 50078155 136 + 0.139 0.189 0.527
ENSG00000155393 E025 0.9638080 0.3874941386 0.418419910   16 50078156 50078740 585 + 0.193 0.428 1.585
ENSG00000155393 E026 176.4637366 0.0075639054 0.083286228 0.25134464 16 50078741 50078943 203 + 2.208 2.144 -0.216
ENSG00000155393 E027 99.6402615 0.0048226386 0.081108983 0.24704374 16 50078944 50079018 75 + 1.965 1.896 -0.233
ENSG00000155393 E028 0.1779838 0.0431261925 1.000000000   16 50080032 50080262 231 + 0.076 0.001 -6.791
ENSG00000155393 E029 109.5848955 0.0066385673 0.260221722 0.49918820 16 50083937 50084027 91 + 1.999 1.959 -0.133
ENSG00000155393 E030 6.5762515 0.0607834360 0.831121946 0.91442825 16 50084108 50084133 26 + 0.824 0.875 0.197
ENSG00000155393 E031 143.0678858 0.0003267870 0.086250552 0.25689855 16 50084134 50084291 158 + 2.116 2.076 -0.132
ENSG00000155393 E032 2.2249619 0.0097755884 0.461411592 0.67414690 16 50084292 50084435 144 + 0.433 0.572 0.678
ENSG00000155393 E033 100.9318875 0.0025582755 0.160205718 0.37712066 16 50084569 50084651 83 + 1.969 1.922 -0.159
ENSG00000155393 E034 111.7438278 0.0015060622 0.219097840 0.45233765 16 50086215 50086351 137 + 2.009 1.976 -0.112
ENSG00000155393 E035 90.6301591 0.0068214889 0.966195708 0.98499390 16 50094705 50094793 89 + 1.906 1.922 0.055
ENSG00000155393 E036 0.0000000       16 50094794 50094805 12 +      
ENSG00000155393 E037 127.4877428 0.0690432012 0.376823404 0.60969147 16 50100230 50100373 144 + 2.030 2.116 0.287
ENSG00000155393 E038 2.5784428 0.0366651343 0.119426535 0.31493303 16 50100374 50101569 1196 + 0.402 0.687 1.341
ENSG00000155393 E039 1.3883178 0.0432304395 0.925892223 0.96508421 16 50101570 50101668 99 + 0.331 0.323 -0.052
ENSG00000155393 E040 2.4600812 0.0093675594 0.102694023 0.28659853 16 50101669 50102258 590 + 0.402 0.684 1.334
ENSG00000155393 E041 123.7731903 0.0157432663 0.212150390 0.44429927 16 50102259 50102352 94 + 2.017 2.106 0.301
ENSG00000155393 E042 117.3987198 0.0007497871 0.222573486 0.45657492 16 50102353 50102435 83 + 2.003 2.065 0.207
ENSG00000155393 E043 416.3719820 0.0029362179 0.004345119 0.03107083 16 50104939 50107272 2334 + 2.536 2.637 0.337