ENSG00000155158

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297615 ENSG00000155158 HEK293_OSMI2_6hA HEK293_TMG_6hB TTC39B protein_coding protein_coding 0.8239974 0.1681957 1.741551 0.02628836 0.0317713 3.297098 0.08331379 0.0000000 0.4654231 0.00000000 0.253229974 5.571140 0.05861250 0 0.2709667 0.2709667 0.7130680306 0.0001050741 FALSE TRUE
ENST00000380850 ENSG00000155158 HEK293_OSMI2_6hA HEK293_TMG_6hB TTC39B protein_coding protein_coding 0.8239974 0.1681957 1.741551 0.02628836 0.0317713 3.297098 0.22617141 0.0000000 0.2902547 0.00000000 0.175131806 4.908115 0.16893333 0 0.1633333 0.1633333 0.7995637686 0.0001050741 FALSE TRUE
ENST00000507993 ENSG00000155158 HEK293_OSMI2_6hA HEK293_TMG_6hB TTC39B protein_coding protein_coding 0.8239974 0.1681957 1.741551 0.02628836 0.0317713 3.297098 0.09710385 0.0000000 0.2784977 0.00000000 0.278497661 4.850488 0.06580417 0 0.1582000 0.1582000 1.0000000000 0.0001050741 FALSE TRUE
ENST00000512701 ENSG00000155158 HEK293_OSMI2_6hA HEK293_TMG_6hB TTC39B protein_coding protein_coding 0.8239974 0.1681957 1.741551 0.02628836 0.0317713 3.297098 0.35951261 0.1681957 0.6653364 0.02628836 0.008636323 1.922144 0.61929167 1 0.3824667 -0.6175333 0.0001050741 0.0001050741 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155158 E001 73.2410225 0.014966426 9.340672e-06 0.0001977881 9 15163622 15171563 7942 - 1.670 1.930 0.878
ENSG00000155158 E002 3.1399620 0.008617290 9.739985e-01 0.9888652530 9 15171564 15171676 113 - 0.507 0.531 0.113
ENSG00000155158 E003 3.7741844 0.031793740 3.341089e-01 0.5726929578 9 15171677 15171918 242 - 0.587 0.414 -0.847
ENSG00000155158 E004 1.4992578 0.143993715 2.176592e-01 0.4506080566 9 15171919 15171928 10 - 0.357 0.000 -11.944
ENSG00000155158 E005 2.2853423 0.068996624 7.406096e-02 0.2328658953 9 15171929 15171945 17 - 0.467 0.000 -12.485
ENSG00000155158 E006 9.3960338 0.032867805 7.495667e-01 0.8664914705 9 15171946 15172109 164 - 0.887 0.869 -0.070
ENSG00000155158 E007 8.7818935 0.004356128 6.045065e-01 0.7731985286 9 15175019 15175135 117 - 0.860 0.819 -0.158
ENSG00000155158 E008 5.7530547 0.004968669 2.166291e-01 0.4494637363 9 15177697 15177814 118 - 0.724 0.531 -0.842
ENSG00000155158 E009 6.8207701 0.030823213 3.047745e-01 0.5453518859 9 15182307 15182415 109 - 0.777 0.622 -0.646
ENSG00000155158 E010 6.4376355 0.004616346 6.246670e-01 0.7871336938 9 15185280 15185406 127 - 0.745 0.699 -0.189
ENSG00000155158 E011 0.1426347 0.033880017 1.000000e+00   9 15185407 15185528 122 - 0.053 0.000 -8.769
ENSG00000155158 E012 0.0000000       9 15186587 15186943 357 -      
ENSG00000155158 E013 5.3050667 0.031315851 6.985378e-01 0.8346546269 9 15186944 15187035 92 - 0.669 0.625 -0.189
ENSG00000155158 E014 6.8077000 0.033090758 1.644377e-01 0.3832998403 9 15187971 15188132 162 - 0.777 0.533 -1.048
ENSG00000155158 E015 6.2695805 0.004898347 4.808767e-02 0.1751956012 9 15189574 15189633 60 - 0.765 0.415 -1.590
ENSG00000155158 E016 0.0000000       9 15189704 15189724 21 -      
ENSG00000155158 E017 7.2062943 0.004159497 2.096979e-01 0.4415230495 9 15189725 15189792 68 - 0.802 0.623 -0.737
ENSG00000155158 E018 7.2548647 0.004522413 6.359772e-01 0.7942690209 9 15190554 15190662 109 - 0.765 0.869 0.408
ENSG00000155158 E019 5.3700399 0.016249138 4.842665e-01 0.6900104644 9 15191190 15191255 66 - 0.666 0.817 0.612
ENSG00000155158 E020 6.3104554 0.005035070 9.699079e-01 0.9867938794 9 15192590 15192695 106 - 0.734 0.763 0.115
ENSG00000155158 E021 4.9820495 0.005920442 5.954031e-01 0.7673107645 9 15199861 15199925 65 - 0.642 0.763 0.502
ENSG00000155158 E022 4.5414879 0.033193251 1.960906e-01 0.4246650223 9 15203823 15203890 68 - 0.654 0.414 -1.140
ENSG00000155158 E023 4.8643193 0.006321951 1.340601e-01 0.3381931551 9 15210088 15210164 77 - 0.679 0.415 -1.240
ENSG00000155158 E024 5.9226687 0.013490751 1.988446e-01 0.4282231185 9 15211266 15211397 132 - 0.735 0.530 -0.891
ENSG00000155158 E025 0.0000000       9 15214138 15214138 1 -      
ENSG00000155158 E026 5.3179486 0.005662041 2.975003e-01 0.5380274288 9 15214139 15214249 111 - 0.691 0.531 -0.704
ENSG00000155158 E027 0.0000000       9 15224340 15224359 20 -      
ENSG00000155158 E028 0.0000000       9 15224360 15224505 146 -      
ENSG00000155158 E029 4.4503245 0.007920969 5.409542e-02 0.1892904856 9 15225917 15226012 96 - 0.642 0.255 -2.083
ENSG00000155158 E030 0.0000000       9 15232232 15232444 213 -      
ENSG00000155158 E031 0.0000000       9 15249042 15249687 646 -      
ENSG00000155158 E032 0.1779838 0.037230325 1.000000e+00   9 15249918 15250010 93 - 0.053 0.000 -8.773
ENSG00000155158 E033 0.0000000       9 15250011 15250116 106 -      
ENSG00000155158 E034 3.2187929 0.007402424 1.535853e-01 0.3674367508 9 15267914 15267948 35 - 0.541 0.255 -1.628
ENSG00000155158 E035 4.7771024 0.006733693 8.963645e-01 0.9499944428 9 15307084 15307360 277 - 0.642 0.698 0.238