ENSG00000155099

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285419 ENSG00000155099 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP4P2 protein_coding protein_coding 2.219721 1.918323 2.558748 0.3629199 0.2225903 0.4137186 0.7731498 0.35869330 1.2534310 0.07078504 0.07774785 1.77685373 0.36343333 0.19623333 0.4938667 0.29763333 0.02326073 0.02326073 FALSE TRUE
ENST00000518359 ENSG00000155099 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP4P2 protein_coding nonsense_mediated_decay 2.219721 1.918323 2.558748 0.3629199 0.2225903 0.4137186 0.5730377 1.06675285 0.2029327 0.15329108 0.20293274 -2.33821742 0.26695417 0.57003333 0.0952000 -0.47483333 0.11983126 0.02326073 TRUE TRUE
ENST00000518869 ENSG00000155099 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP4P2 protein_coding nonsense_mediated_decay 2.219721 1.918323 2.558748 0.3629199 0.2225903 0.4137186 0.1725859 0.05150149 0.2704668 0.05150149 0.13526305 2.18913692 0.07847083 0.01953333 0.1101667 0.09063333 0.70390336 0.02326073   FALSE
ENST00000520014 ENSG00000155099 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP4P2 protein_coding protein_coding 2.219721 1.918323 2.558748 0.3629199 0.2225903 0.4137186 0.4676792 0.44137528 0.4237079 0.24967539 0.42370794 -0.05760354 0.20066667 0.21420000 0.1591333 -0.05506667 0.74852519 0.02326073 FALSE FALSE
ENST00000520709 ENSG00000155099 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP4P2 protein_coding nonsense_mediated_decay 2.219721 1.918323 2.558748 0.3629199 0.2225903 0.4137186 0.2332679 0.00000000 0.4082094 0.00000000 0.40820941 5.38615361 0.09050000 0.00000000 0.1416667 0.14166667 0.90882832 0.02326073 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000155099 E001 24.4844911 0.020152655 0.0001577508 0.002192284 8 90993802 90995523 1722 - 1.519 1.181 -1.177
ENSG00000155099 E002 7.8592636 0.004658688 0.0025154603 0.020430581 8 90995524 90995592 69 - 1.075 0.707 -1.409
ENSG00000155099 E003 15.0146114 0.028493902 0.0915960232 0.266646864 8 90995593 90995716 124 - 1.270 1.096 -0.617
ENSG00000155099 E004 15.9094004 0.002547690 0.9932757020 0.998301806 8 90995717 90995810 94 - 1.228 1.222 -0.022
ENSG00000155099 E005 9.0985435 0.003538030 0.7306216460 0.854567468 8 90995811 90995820 10 - 0.984 1.014 0.110
ENSG00000155099 E006 14.5174487 0.002429557 0.9202541061 0.962339846 8 90996654 90996744 91 - 1.190 1.192 0.004
ENSG00000155099 E007 10.6310414 0.004210729 0.8589145361 0.929800883 8 91008743 91008795 53 - 1.064 1.073 0.031
ENSG00000155099 E008 16.4473484 0.198078728 0.2403360007 0.476952497 8 91018390 91018513 124 - 1.178 1.315 0.485
ENSG00000155099 E009 17.5824988 0.002645443 0.0147497769 0.077141183 8 91020157 91020263 107 - 1.182 1.362 0.630
ENSG00000155099 E010 17.4956401 0.002409257 0.0006479390 0.006986903 8 91021256 91021404 149 - 1.132 1.389 0.906
ENSG00000155099 E011 0.3453689 0.026099931 0.8199712647   8 91021405 91021422 18 - 0.107 0.138 0.422
ENSG00000155099 E012 0.3641499 0.027867551 0.8214493205   8 91024289 91024301 13 - 0.107 0.138 0.421
ENSG00000155099 E013 0.5421338 0.025273947 0.7560696845   8 91024302 91024366 65 - 0.193 0.138 -0.580
ENSG00000155099 E014 10.0187346 0.004064354 0.1860625799 0.411916535 8 91040644 91040872 229 - 0.972 1.100 0.469