ENSG00000154582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284811 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding protein_coding 90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 28.181274 13.603760 37.303831 3.7207330 2.5858805 1.4546449 0.30556250 0.28516667 0.37110000 0.085933333 7.359288e-01 1.310535e-07 FALSE  
ENST00000518127 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding protein_coding 90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 6.623412 1.258164 10.389209 0.2189233 0.2388279 3.0356611 0.06885000 0.02780000 0.10226667 0.074466667 1.310535e-07 1.310535e-07 FALSE  
ENST00000519082 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding protein_coding 90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 9.194927 4.447043 9.990440 0.9538826 0.4601182 1.1659047 0.10311250 0.09476667 0.09833333 0.003566667 9.781430e-01 1.310535e-07    
ENST00000523815 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding protein_coding 90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 7.402372 3.885574 6.698334 1.3535451 2.4293176 0.7841185 0.08355417 0.08540000 0.06413333 -0.021266667 8.824212e-01 1.310535e-07 FALSE  
MSTRG.31641.15 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding   90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 11.441095 6.082030 11.509302 3.3193278 5.8612876 0.9190583 0.12904167 0.14000000 0.10710000 -0.032900000 1.000000e+00 1.310535e-07 FALSE  
MSTRG.31641.17 ENSG00000154582 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOC protein_coding   90.44424 46.00052 101.9221 7.20145 5.454282 1.147573 17.860891 11.611952 16.073505 1.4454680 0.4524083 0.4687294 0.20152917 0.25650000 0.15820000 -0.098300000 7.548620e-03 1.310535e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000154582 E001 0.8489605 0.2169737444 6.066228e-01   8 73939169 73941605 2437 - 0.287 0.163 -1.045
ENSG00000154582 E002 0.7035494 0.0369492094 7.315011e-01   8 73945119 73945165 47 - 0.229 0.162 -0.619
ENSG00000154582 E003 1.6758000 0.1549919828 4.566234e-01 6.707363e-01 8 73945166 73945429 264 - 0.454 0.284 -1.004
ENSG00000154582 E004 1.8124653 0.0655916895 8.263301e-02 2.499641e-01 8 73945430 73945607 178 - 0.520 0.162 -2.353
ENSG00000154582 E005 96.1557825 0.0017939046 3.011891e-19 7.905538e-17 8 73945608 73946400 793 - 2.074 1.632 -1.488
ENSG00000154582 E006 52.7794890 0.0010699169 2.875885e-09 1.521943e-07 8 73946401 73946417 17 - 1.805 1.454 -1.193
ENSG00000154582 E007 70.6456668 0.0079218492 1.368764e-05 2.751510e-04 8 73946418 73946435 18 - 1.913 1.626 -0.972
ENSG00000154582 E008 88.1935773 0.0339964936 1.492530e-02 7.781234e-02 8 73946436 73946472 37 - 1.997 1.762 -0.790
ENSG00000154582 E009 91.9272987 0.0268808630 1.995980e-02 9.572801e-02 8 73946473 73946533 61 - 2.007 1.802 -0.689
ENSG00000154582 E010 468.2542878 0.0005926218 3.402643e-01 5.781881e-01 8 73946534 73946699 166 - 2.660 2.634 -0.088
ENSG00000154582 E011 685.8114778 0.0004646257 2.107213e-01 4.426686e-01 8 73946700 73946820 121 - 2.812 2.822 0.033
ENSG00000154582 E012 13.0124631 0.0477163900 2.715470e-02 1.187670e-01 8 73955647 73955757 111 - 1.005 1.288 1.013
ENSG00000154582 E013 4.7856534 0.0059175669 1.950327e-02 9.421132e-02 8 73955758 73955761 4 - 0.602 0.915 1.264
ENSG00000154582 E014 4.2386478 0.0454576053 4.383457e-02 1.646965e-01 8 73955762 73955763 2 - 0.551 0.867 1.315
ENSG00000154582 E015 2.4927850 0.0828602791 3.552490e-01 5.919533e-01 8 73955764 73955765 2 - 0.457 0.620 0.763
ENSG00000154582 E016 3.2750479 0.0138466361 8.669913e-01 9.343453e-01 8 73955766 73955910 145 - 0.602 0.620 0.078
ENSG00000154582 E017 891.9685416 0.0002100531 3.776750e-03 2.789211e-02 8 73955911 73956054 144 - 2.921 2.946 0.085
ENSG00000154582 E018 482.2221092 0.0006659658 1.572589e-03 1.412854e-02 8 73959765 73959818 54 - 2.644 2.695 0.168
ENSG00000154582 E019 2.9504287 0.0615370187 3.874420e-01 6.184477e-01 8 73959819 73963842 4024 - 0.521 0.665 0.644
ENSG00000154582 E020 77.4706749 0.0005451370 4.708293e-01 6.807039e-01 8 73964487 73964625 139 - 1.868 1.890 0.075
ENSG00000154582 E021 3.2014015 0.0779916425 8.832081e-01 9.429478e-01 8 73964626 73964629 4 - 0.599 0.621 0.094
ENSG00000154582 E022 6.0047192 0.0110848424 4.177345e-01 6.419269e-01 8 73969560 73969673 114 - 0.860 0.740 -0.474
ENSG00000154582 E023 2.8216559 0.0236753681 3.498323e-01 5.870916e-01 8 73970579 73970634 56 - 0.519 0.663 0.646
ENSG00000154582 E024 2.0146495 0.2531983576 6.656031e-01 8.134092e-01 8 73971870 73972041 172 - 0.515 0.371 -0.756
ENSG00000154582 E025 12.2229116 0.0436771743 9.116982e-01 9.580187e-01 8 73972042 73972076 35 - 1.100 1.091 -0.033
ENSG00000154582 E026 222.1142702 0.0004408828 2.297541e-25 1.211725e-22 8 73972077 73972244 168 - 2.223 2.473 0.833
ENSG00000154582 E027 111.7406302 0.0034819662 5.999823e-14 7.801745e-12 8 73972245 73972307 63 - 2.126 1.746 -1.279